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Post by beebs on Apr 29, 2011 14:06:15 GMT -5
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Post by beebs on Apr 29, 2011 14:11:11 GMT -5
This is not the best article on the subject. I had much more comprehensive table with many drugs, including, anti histamines, corticosteroids, etc.. Will post it when I find it. Drugs that can alter cardiac electro-conductivity: QT Interval Prolongation. Drug-Related QT Interval Prolongation: Drugs Associated with QT Prolongation * Abstract and Introduction * Mechanism of QT Interval Prolongation * Drugs Associated with QT Prolongation * Drug Interactions * Regulatory Impact * References Information from Industry Discover tetanus prophylaxis with immune therapy Achieve rapid immune protection from tetanus with immune therapy. Learn more Important Safety Information Prescribing Information Drugs Associated with QT Prolongation Drugs associated with QT prolongation, torsade de pointes, or both are classified by therapeutic class and under each grouping are subdivided into three categories: definite, probable, and proposed association. In a definite association, a positive temporal concordance of drug administration and the event is documented (per published data retrieved from MEDLINE searches), the event disappears or lessens with drug discontinuation, and the event recurs with rechallenge. Additional evidence may include in vitro or in vivo data showing the drug's effects on cardiac ion channels. The second category, probable association, consists of drugs that most likely represent a true risk, but for which there is less complete evidence. The third category contains drugs that have been proposed to cause risk. Drugs may be assigned to this category because of inadequate or contradictory published case reports. In addition, some drugs have been labeled as causing QT prolongation because other drugs in their pharmacologic class have a definite risk of increasing the QT interval. The labeling content derives, of course, from United States Food and Drug Administration (FDA) or manufacturer suggestions, but for these particular drugs, there is no published evidence to support the purported risk. Finally, there are some drugs that have been associated with QT prolongation for which neither published evidence nor product labeling exists, but they are included for the sake of completeness. Table 1 summarizes all these data and includes pertinent information from the product labeling www.medscape.com/viewarticle/458868_3
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Post by beebs on May 10, 2011 11:04:36 GMT -5
Permission to repost: CHANTIX Linked to Highest # Reports--Hostility-Aggression, PsychosisFYI The latest January 2011 QuarterWatch (analyzing MedWatch adverse effect reports for Quarter 2 of 2010) found that overall,the FDA received 33,068 domestic reports of serious injury, disability or death associated with drug therapy in this quarter. This was an increase of 12% from the same quarter one year ago and little changed from the revious quarter. www.ismp.org/QuarterWatch/2010Q2.pdfA year after FDA required a prominent boxed warning, a mandatory Medication Guide for every patient and declining use, CHANTIX continued to account for the largest numbers of reported serious psychiatric side effects that pose serious risks of harm. The case reports involving CHANTIX, primarily of hostility-aggression, depression and psychosis, pose serious risks--not only to those who use it--but also to others who may be victimized by consumers of the drug who become psychotic or aggressive. For this reason, the Federal Aviation Administration has banned varenicline for pilots and air traffic controllers; the Department of Transportation has limited its use among truck drivers; and the Department of Defense has banned it for use by some military personnel, including pilots and missile crews. QuarterWatch reports: "In the second quarter OF 2010, CHANTIX accounted for 130 possible cases of clinical depression, 112 possible cases of hostility-aggression, and 70 cases of psychosis or losing touch with reality. " So, why has the FDA failed to protect the public at large? The time has come for the FDA use its regulatory authority to withdraw CHANTIX from the market to protect the public at large--including children, families, neighbors--from drug-induced violence. Read more.... www.ahrp.org/cms/content/blogsection/0/9/
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Post by beebs on Jan 6, 2012 8:08:29 GMT -5
Come ON, of course psychs are aware, that is precisely why the prescribe, life long patients=$$$$Commentary: A National Epidemic of Unintentional Prescription Opioid Overdose Deaths: How Physicians Can Help Control It Leonard J. Paulozzi, MD, MPH; Richard H. Weisler, MD; and Ashwin A. Patkar, MD, MRCPsych J Clin Psychiatry 2011;72(5):589–592 10.4088/JCP.10com06560 Copyright 2011 Physicians Postgraduate Press, Inc. Access to this article is free to registered users Both the usage of prescription drugs such as opioid analgesics and benzodiazepines and overdoses involving them have increased dramatically in the United States since the 1990s. Patients using these drugs often have a combination of painful conditions, substance abuse, and other forms of mental illness. Psychiatrists and many primary care physicians might not be familiar with existing evidence-based guidelines for opioid prescribing or with programs designed to reduce the abuse of prescription drugs such as state prescription drug monitoring programs. Psychiatrists need to be informed regarding this problem to partner effectively with both pain specialists and primary care providers in their community. J Clin Psychiatry Submitted: September 7, 2010; accepted March 22, 2011. Online ahead of print: April 19, 2011 (doi:10.4088/JCP.10com06560). Corresponding author: Leonard J. Paulozzi, MD, MPH, 601 Sunland Park Dr, Ste 200, El Paso, TX 79912 (lbp4@cdc.gov). article.psychiatrist.com/dao_1-login.asp?ID=10007389&RSID=1110336358234
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Post by beebs on Jan 17, 2012 9:18:33 GMT -5
Allergic to shellfish? Beware.
Band name Rexall - Vit D 3 and Calcium, found to contain shellfish!!
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Post by beebs on Jan 17, 2012 9:19:42 GMT -5
Anti-inflammatory Motrin, by McNeill, recalled in 2011 because it does not dissolve as fast.
WHY??
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Post by beebs on Jan 17, 2012 9:41:24 GMT -5
Lexapro (Escitalopram)So, yes, doctors are fully aware of possible side effects. They are sent regular updates and alerts. Yet, denial and dismissing reports is endemic. QT-interval prolongation reported, ventricular arrythmias, and other types of arrythmias, torsade de pointes.. Some contraindications include: antimicrobials, some FQs, erythromycin (famous for causing sudden cardiac death), other anti depressants, impaired liver function see pdf here: www.mhra.gov.uk/Safetyinformation/Safetywarningsalertsandrecalls/Safetywarningsandmessagesformedicines/Monthlylistsofinformationforhealthcareprofessionalsonthesafetyofmedicines/CON140590
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Post by beebs on Jan 17, 2012 9:49:58 GMT -5
Seroquel:
Wow, a long list of side effects, includes metabolic syndrome, elevate TSH (Ooops, does that not equate causing hypothyroidism or other thyroid imbalance?).
Long QT intervals also mentioned
Common side effects:
Concomitant administration of cytochrome P450 3A4 inhibitors, such as HIV-protease inhibitors, azole-antifungal agents, erythromycin, clarithromycin and nefazodone. Precautions: Depression in bipolar disorder is associated with an increased risk of suicidal thoughts, self- harm and suicide. This risk persists until significant remission occurs - closely monitor patients until such improvement occurs. Risk of suicide may increase in early stages of recovery. In clinical studies of patients with major depressive episodes in bipolar disorder an increased risk of suicide-related events observed in adult patients less than 25 years of age treated with quetiapine compared to those treated with placebo. Consider risk of suicide-related events after abrupt cessation of quetiapine. Quetiapine treatment associated with somnolence and
Common: Dizziness and somnolence (may lead to falls), headache, dry mouth, withdrawal symptoms such as nausea, vomiting, insomnia, headache, diarrhoea, dizziness and irritability, elevations in serum triglyceride levels and total cholesterol (predominantly LDL cholesterol), decreases in HDL cholesterol, weight gain, decreased haemoglobin, leucopenia, hyperprolactinaemia, increased appetite, abnormal dreams and nightmares, syncope and orthostatic hypotension (may lead to falls), extrapyramidal symptoms, dysarthria, tachycardia, palpitations, blurred vision, rhinitis, dyspnea, constipation, dyspepsia, vomiting, mild asthenia, peripheral oedema, irritability, pyrexia, elevations in serum transaminases (ALT, AST), decreased neutrophil count, increased blood glucose to hyperglycaemic levels, decreases in total T 4, free T4 and total T3, increases in TSH
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Post by beebs on Feb 16, 2012 10:16:38 GMT -5
Read somewhere that Dr Syney Wolfe no longer works for the FDA, it was just a matter of time, before they rid of someone with ethics and integrity!!
FDA’s Rejection of Public Citizen’s Petition to Ban Avandia Translates to More Harm to Patients
Statement of Dr. Sidney Wolfe, Director, Public Citizen’s Health Research Group
Late yesterday, the Food and Drug Administration (FDA) faxed Public Citizen its letter rejecting our Oct. 30, 2008, petition in which we asked the FDA to ban the diabetes drug Avandia (rosiglitazone) because its benefits were greatly outweighed by its multiple risks, including increased heart attacks, heart failure, fractures, vision-threatening macular edema and other serious problems. In September 2010, the European Medicines Agency (EMA) announced a ban of the drug because of its decision that Avandia’s benefits were clearly outweighed by its risks and that additional restrictions to reduce risk could not be identified.* Subsequently, it also has been banned in New Zealand, India and other countries.
In the year since the EMA announcement, according to health-care analytics experts IMS, there have been approximately 1.1 million prescriptions for Avandia-containing drugs filled in the U.S., thereby ensuring the occurrence of hundreds or more patients suffering heart attacks and cases of severe heart failure – including many deaths and hospitalizations. All of this from a drug deemed too dangerous to stay on the market in all of Europe and in an increasing number of other countries.
The FDA’s decision not to ban the drug but to limit prescriptions for the drug, so that patients will have allegedly tried other treatments first, is a dangerous and reckless refutation of the precautionary principle that is supposed to guide decisions involving public health. The evidence shows the drug has no unique clinical benefits but unique risks. Unless the FDA can provide evidence that Americans are more resistant to the life-threatening adverse effects of Avandia than people in Europe and the other countries that have banned the drug, this decision, unlike the wise decision last week concerning Avastin, cannot be described as science-based or rational.
The FDA’s rejection of our petition closely follows the announcement by the manufacturer of rosiglitazone, GSK, that it has agreed to pay $3 billion in civil and criminal penalties including the illegal marketing of this drug.
*From the EMA press release announcing the ban:
“The availability of recent studies has added to the knowledge about rosiglitazone and overall, the accumulated data support an increased cardiovascular risk of rosiglitazone. In view of the restrictions already in place on the use of rosiglitazone, the Committee could not identify additional measures that would reduce the cardiovascular risk. The Committee therefore concluded that the benefits of rosiglitazone no longer outweigh its risks and recommended the suspension of the marketing authorisation of the medicines.”
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Post by beebs on Feb 18, 2012 7:40:22 GMT -5
Adding to the list of meds that can cause Parkionsonian's diseases: Halothane and Quinine. Mentions high dose in the article, but, then, minute dose of pharmaceuticals known to reach toxicity level rapidly. See the article here: www.jmedicalcasereports.com/content/5/1/105Quinine was the first antimalarial drug available, which has been in use since the 17th century [2]. Quinine is a natural white crystalline alkaloid with antipyretic effects. It is a stereoisomer of quinidine, which has an antiarrhythmic effect. Side effects of quinine include cinchonism, pulmonary oedema, abnormal heart rhythms and hearing impairment [3]. Contrary to popular belief, quinine is an ineffective abortifacient, and is recommended by World Health Organization (WHO) for use in pregnancy [4]. The mechanism of action of quinine is still elusive but the most popular hypothesis is inhibition of hemozoin biocrystallization leading to formation of cytotoxic heme, which accumulates within the malaria parasites and causes their death [5]. Halothane is an inhalational anaesthetic agent, chemically designated 2-bromo-2-chloro-1,1,1-trifluoroethane. Halothane anaesthesia augments the action of nondepolarizing skeletal muscle relaxants and ganglionic blocking agents, and is also a potent uterine relaxant [6]. The side effects include hepatic necrosis, cardiac and respiratory arrest, hypotension, cardiac arrhythmias, hyperpyrexia, shivering, nausea and emesis [6]. Several drugs and toxins have been reported to cause parkinsonism, but to the best of our knowledge, there has been no report of parkinsonism induced by quinine or halothane. They go on in the article describing two cases, one induced by Quinine and the second by Halothane!! I suspect there are more cases unreported and undocumented...../Drugs are the most common causes of parkinsonism in the general population, and are generally d rugs that block postsynaptic dopamine receptors or deplete presynaptic dopamine. Several drugs have been implicated as a cause of parkinsonism, including dopamine antagonists such as prochlorperazine for giddiness, metoclopramide for dyspepsia and chlorpromazine for bipolar depression; calcium-channel blockers such as flunarizine and Cinnarizine; and sodium valproate for epilepsy and migraine headache. Some of these medications may also be adulterated because of increased access via the internet [10].
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Post by beebs on Mar 21, 2012 15:35:27 GMT -5
Email sent to me from an MD:
Please Read Very Carefully - INFORM ALL YOUR FRIENDS & FAMILY MEMBERS India has become a dumping ground for banned drugs; also the business for production of banned drugs is booming. Plz make sure that u buy drugs only if prescribed by a doctor(Also, ask which company manufactures it, this would help to ensure that u get what is prescribed at the Drug Store) and that also from a reputed drug store. Not many people know about these banned drugs and consume them causing a lot of damage to themselves. We forward Jokes and other junk all the time.... This is far more important.
Please Make sure u forward it everyone u know.
DANGEROUS DRUGS HAVE BEEN GLOBALLY DISCARDED BUT ARE AVAILABLE IN INDIA .... The most common ones are action 500 & Nimulid.
PHENYLPROPANOLAMINE: cold and cough. Reason for ban : stroke. Brand name : Vicks Action-500 ______________________________ __________________________________________ ANALGIN: This is a pain-killer. Reason for ban: Bone marrow depression. Brand name: ! Novalgin ___________________________________________________________ CISAPRIDE: Acidity, constipation. Reason for ban : irregular heartbeat Brand name : Ciza, Syspride ____________________________________________________________ DROPERIDOL: Anti-depressant. Reason for ban : Irregular heartbeat. Brand name : Droperol ______________________________________________________________ FURAZOLIDONE: Antidiarrhoeal. Reason for ban : Cancer. Brand name : Furoxone, Lomofen _____________________________________________________________ NIMESULIDE: Painkiller, fever. Reason for ban : Liver failure.. Brand name : Nise, Nimulid ________________________________________________________________________
NITROFURAZONE: Antibacterial cream. Reason for ban : Cancer. Brand name : Furacin ________________________________________________________________________
PHENOLPHTHALEIN: Laxative... Reason for ban : Cancer. Brand name : Agarol ________! ______________________ __________________________________________
OXYPHENBUTAZONE: Non-steroidal anti-inflammatory drug. Reason for ban : Bone marrow depression. Brand name : Sioril _______________________________________________________________________ PIPERAZINE: Anti-worms.... Reason for ban : Nerve damage. Brand name : Piperazine ________________________________________________________________________ QUINIODOCHLOR: Anti-diarrhoeal. Reason for ban : Damage to sight. Brand name: Enteroquinol
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Post by Admin on Apr 1, 2012 13:23:18 GMT -5
Excerpt from an article about contamination, defects from biologic products (includes vaccines): Recalls Threaten Public Confidence In Vaccines And Immunoglobulins March 27, 2012 Quality defects and donor tissue history must be more carefully monitored to increase public acceptance if the biologics market is to succeed, according to a new report by business intelligence experts GBI Research. The new report refers to the emerging pattern emerging in drug recalls over recent years, which shows that vaccines and immunoglobulins, in particular, have failed to meet safety standards. Biologics are drugs that contain an active substance produced by or extracted from a biological living source, which can include humans, animals, cells or microorganisms. Biological products and biologics have definite risks, as they are often only partially understood at the time of approval, with a highly complex production and purification process. Products extracted from human blood or plasma also carry the risk of contamination with pathogens from the donor. Biomedical Tissue Services (BTS) recalled human tissue in October 2005 after the company discovered that tissue may have been procured from donors without properly evaluated medical and social histories. This prompted companies such as Regeneration Technologies, Inc. and Tutogen Medical, Inc. to also recall human tissue products. www.pharmaceuticalonline.com/article.mvc/Recalls-Threaten-Public-Confidence-In-0001
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Post by beebs on Apr 27, 2012 17:00:37 GMT -5
On the FDA watch list: Product Name: Active Ingredient (Trade) or Product Class Potential Signal of a Serious Risk/New Safety Information Additional Information (as of February 15, 2012)* Bortezomib (Velcade, Takeda) Death from intrathecal administration (medication error) The Dosage and Administration and Contraindications sections of the labeling for bortezomib were updated January 2012 to include fatal events with intrathecal administration.] Brentuximab vedotin (Adcetris, Seattle Genetics) Progressive multifocal leukoencephalopathy (PML) The Boxed Warning and Warnings and Precautions sections of the labeling for brentuximab were updated January 2012 to include PML. Fluoroquinolone products Peripheral sensorimotor neuropathy FDA is continuing to evaluate this issue to determine whether the current labeling, which contains information about peripheral sensorimotor neuropathy, is adequate. Gabapentin HCl (Neurontin, Pfizer) Increase in blood creatine phosphokinase levels and rhabdomyolysis Gadolinium-based contrast agents products Acute kidney injury FDA is continuing to evaluate this issue to determine whether the current labeling, which contains information about kidney injury, is adequate. Iloprost inhalation solution (Ventavis, Actelion Pharmaceuticals) Hemoptysis Loperamide HCl–containing products (Imodium, McNeal Consumer Healthcare) Pancreatitis Magnesium sulfate for injection Fetal skeletal demineralization, hypermagnesemia, and other bone abnormalities with continuous long-term use in pregnant women Milnacipran HCl (Savella, Forest Pharmaceutica) Homicidal ideation Pegloticase (Krystexxa, Savient Pharmaceuticals) Anaphylaxis and infusion reactions Phenytoin (Dilantin, Pfizer) and nondepolarizing neuromuscular blocking agents. Drug interactions resulting in decreased effectiveness of the nondepolarizing neuromuscular blocking agent Polyethylene glycol 3350 over-the-counter oral laxative (Miralax, MSD Consumer Care) Neuropsychiatric events. FDA decided that no action is necessary at this time on the basis of available information. Proton-pump inhibitor over-the-counter (OTC) products Clostridium difficile-associated diarrhea Rubidium Rb82 generator (CardioGen-82, Bracco Diagnostics) Unintended radiation exposure to strontium isotopes after myocardial imaging Rubidium Rb82 generator was voluntarily recalled by the manufacturer in July 2011; a return to the US market is planned. The Boxed Warning, Dosage and Administration, and Warnings and Precautions sections of the labeling for rubidium Rb82 generator were updated February 2012 to include information about unintended radiation exposure. Sorafenib tosylate (Nexavar, Onyx Pharmaceuticals) Osteonecrosis of the jaw Telaprevir (Incivek, Vertex Pharmaceuticals) Serious skin reactions, including drug reaction with eosinophilia and systemic symptoms (DRESS) and Stevens-Johnson syndrome (SJS) *Unless otherwise noted, the FDA is continuing to evaluate these issues to determine the need for any regulatory action. Topical analgesic nonprescription monograph products containing menthol, methyl salicylate, and capsaicin Application site burns FDA is continuing to evaluate this issue to determine whether the current labeling for the monograph products is adequate. Orlistat (Alli, GlaxoSmithKline)Kidney stones FDA is continuing to evaluate this issue to determine whether the current labeling for orlistat, which includes kidney stones, is adequate to address other kidney-related adverse events. The Warnings and Precautions and Adverse Reactions sections of the labeling for Xenica (the prescription orlistat product) were updated January 2012 to include increases in urinary oxalate. The European Medicines Agency is also evaluating orlistat for this potential risk. Valproate products: valproic acid, divalproex sodium, valproate sodium Liver failure and injury (involving hereditary mitochondrial disorders, such as Alpers-Huttenlocher syndrome and other conditions) *Unless otherwise noted, the FDA is continuing to evaluate these issues to determine the need for any regulatory action. More information on these watch-list drugs from the second half of 2011 and their potential safety issues is available on the FDA's Web site. Cont/... www.medscape.com/
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Post by beebs on May 1, 2012 15:30:05 GMT -5
Epinephrine injections recall. Beware. If slighly pinkish throw away. Read on: April 30, 2012 — Epinephrine injections contained in a lot manufactured by Luitpold Pharmaceuticals Inc and distributed by American Regent are being voluntarily recalled because of discoloration and small visible particles. The company submitted a written release, posted as part of the Food and Drug Administration's MedWatch Safety Information and Adverse Event Reporting Program. The recall is limited to a single lot, #1395; discoloration and small visible particles have been found in some ampules of this lot. The epinephrine injection is USP, 1:1000, sold in 1-mL ampules, National Drug Code #0517-1071-25. The expiration date is July 2012, and the product was distributed to wholesalers and distributors nationwide. ...... .http://www.medscape.com/viewarticle/762960?sssdmh=dm1.780699&src=nldne
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Post by beebs on May 11, 2012 14:12:57 GMT -5
Check if you are taking the drug pioglitazone, or look up pharmacological compounds and compare. Merck net profit for the quarter of 2012, hit $1.37 billion, boosed by sales of Januvia, diabetes drug, netted $319 million... www.bloomberg.com/news/2012-04-27/merck-profit-tops-analyst-estimates-on-sales-of-diabetes-drugs.html ;D Whilstleblower denounces cover up about diabetis drug causing congestive heart failure, read on: Whistleblower Suit Claims Pioglitazone Cover-up Suit Implicates Dr Steven Nissen, Cleveland ClinicShelley Wood May 10, 2012 (Boston, Massachusetts) — Lawyers representing Takeda Pharmaceuticals have one more day to either file an answer to or challenge the validity of a whistleblower suit centered, in part, on the underreporting of congestive heart failure (CHF) events with the company's diabetes drug, pioglitazone (Actos). Dr Helen Ge, a former employee at Takeda, alleges that false claims for payment were made to Medicare and other federally funded healthcare programs on the grounds that the company "was able to capture a majority of the diabetes drug market by falsely portraying Actos as safer than it actually was." "But for Takeda's fraud, government healthcare programs would have paid for substantially fewer Actos claims" and physicians would have prescribed it less, the whistleblower suit alleges. Suit goes it alone Ge's qui tam suit, launched in June 2010, is seeking damages and civil penalties from Takeda on behalf of the US government; her attorneys are proceeding with the litigation, despite a decision by the feds and the 25 states with similar false claims act legislation to decline to intervene in the case. One of Ge's lawyers insisted to heartwire that it is "not unusual" for government to decline to intervene; in this case, the Justice Department spent a year and a half reviewing the case before opting out, attorney Michael Baum explained. The feds will continue to monitor the case, and if litigation is successful or if discovery turns up information that changes their minds, "they might intervene earlier," Baum said. "Our view, having worked on a lot of pharmaceutical cases and having a pretty good idea from our whistleblower what things we will find in discovery, we feel that the case should proceed and we should conduct discovery, and discovery will bear out Dr Ge's allegations." Ge's lawyers hope to "obtain internal emails and publication plans and marketing plans that will provide further support to our contentions in the complaint," Baum said. Underreporting of known, serious side effects Ge's suit alleges that Takeda failed to properly report CHF cases to the FDA and instructed medical reviewers, Ge included, to not report hundreds of nonhospitalized or nonfatal CHF cases as "serious" after the boxed warning was added to thiazolidinedione (TZD) drugs in 2007. Only "serious" adverse events for older drugs end up in the FDA's Adverse-Event Reporting System, the suit alleges, thus boosting the company's alleged aim of positioning its drug as safer than rosiglitazone. Ge says her contract with Takeda was terminated after she complained to three superiors about the downgrading of CHF events. Her suit also states that the number of CHF reports dropped dramatically in 2010, after she was fired from the company, despite rising sales of the drug. Ge's suit also details alleged cover-up of reports of other adverse events, including cancers, suicidal ideation, renal failure, and cardiomyopathy, among others. Financial conflicts alleged with Nissen, Cleveland Clinic Ge's suit names only the pharmaceutical company as defendant but does allege that financial connections between the Cleveland Clinic's Dr Steven Nissen "should be considered when analyzing Actos's risks compared with Avandia's." Nissen, with Kathy Wolski, famously published the rosiglitazone meta-analysis that set off the TZD firestorm, showing a 43% increase in MI with pioglitazone's chief competitor. Ge's suit cites the Nissen paper as a key factor in Takeda's efforts to position pioglitazone as a safer alternative to rosiglitazone. Nissen, the suit notes, was principal investigator for the phase 3 PERISCOPE trial, which used intravascular ultrasound (IVUS) to screen patients for trial eligibility, then repeat IVUS imaging for trial participants. Ge's suit estimates that "payment Nissen received from Takeda through Cleveland Clinic Foundation was estimated to be $8 million to $10 million" for PERISCOPE and that IVUS procedures likely brought in over $13 million in revenue for the Cleveland Clinic. Cont/.. www.medscape.com/viewarticle/763658?sssdmh=dm1.783490&src=nldne
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Post by beebs on May 13, 2012 16:16:29 GMT -5
Not quite a drug, Red Bull has been banned in some countries. Calls to regulate in South Africa and the UK. Mentions of energy drinks, the article focuses on Red Bull. Excerpt from the article: "This year alone, scientists in the US found that one can of Red Bull containing 80 mg of caffeine increased BP compared to 80 mg of caffeine alone in healthy volunteers in a pilot study [2] and an Australian poisons control center has reported on almost 300 cases of toxicity due to ingestion of these drinks [3], with the mean number of drinks consumed in one session being five and the average age of those drinking them being 17. The most common symptoms reported included palpitations, agitation, tremor, and gastrointestinal upset. There were 21 subjects with signs of serious cardiac or neurological toxicity, and 128 subjects (including 57 who did not coingest anything else) were hospitalized." www.medscape.com/viewarticle/763274?sssdmh=dm1.781518&src=nldne
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Post by beebs on Jun 1, 2012 13:58:29 GMT -5
Duloxetine (CYMBALTA)
French journal "Prescrire" mentions that this drug should not be used under any circumstances.
Sydney Wolfe, former FDA, back to Public Citizen, concurs.
"A 2005 Public Library of Science Medicine (PLoSM) editorial pointed out:
[T]here is not a single peer-reviewed article that can be accurately cited to directly support claims of serotonin deficiency in any mental disorder, while there are many articles that present counter-evidence."
This theory has been debunked years ago!
Adding to the usual side effects such as halluincation, psychosis, anxiety etc..more info (copied & pasted) from Public Citizen's site:
Suicidality. The FDA requires that duloxetine and all other antidepressants display a black box warning (see duloxetine’s warning) in their product labels regarding the increased risk of suicidal thinking and behavior in children, adolescents and young adults. This effect has been demonstrated in short-term studies of MDD and other psychiatric disorders.
A black box warning is the strongest type of safety alert the FDA can demand of drug manufacturers and can be required when there is evidence of serious injuries or death with a drug.
Drug-drug interactions. Duloxetine must not be used at the same time or around the same time that members of another family of antidepressant drugs, monoamine oxidase inhibitors (MAOIs), are used. The MAOI family consists of four drugs: phenelzine (NARDIL), isocarboxazid (MARPLAN), tranylcypromine (PARNATE) and selegiline (ELDEPRYL).
The use of duloxetine with MAOIs can cause sometimes fatal drug interactions. These interactions may result in elevated temperature, muscle rigidity, muscle spasm, nervous system instability with possible rapid fluctuations of vital signs, and mental status changes that include extreme agitation progressing to delirium and coma.
Serious reactions also may surface when using duloxetine with other drugs. In July 2006, the FDA issued a public health advisory about the possibility of life-threatening reactions that may be caused by the interaction of migraine headache drugs, called triptans (e.g., almotriptan [AXERT]), and certain anti-depressants.
Increased bleeding. Duloxetine use may increase the risk of bleeding, especially when taken with other drugs that affect blood clotting, such as nonsteroidal anti-inflammatory drugs and aspirin.
Liver toxicity and liver failure. Liver toxicity and liver failure, sometimes fatal, have been reported in patients treated with duloxetine. Patients who develop jaundice (yellowing of the skin or eyes) or other evidence of of liver toxicity should stop taking duloxetine and should not restart it unless another cause of these symptoms can be established.
Serotonin syndrome or Neuroleptic malignant syndrome (NMS). Serotonin is found in the brain, blood and gastrointestinal tract. Taking a combination of triptans, selective serotonin reuptake inhibitors and SNRIs (such as duloxetine) can increase serotonin to extremely high levels that could result in serotonin syndrome. Symptoms can include restlessness, hallucinations, loss of coordination, rapid heartbeat, rapid changes in blood pressure, increased body temperature, overactive reflexes, nausea, vomiting and diarrhea. NMS also can occur when the body has too much serotonin.
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Post by beebs on Sept 3, 2012 17:24:21 GMT -5
\ Reumofan Recalled Because of Undeclared Ingredients Emma Hitt, PhD Authors and Disclosures Posted: 08/30/2012 Print This Print This ShareShare August 30, 2012 — A voluntary recall of 500 lots of Reumofan Plus tablets, distributed via the Internet, is underway by its manufacturer, Samantha Lynn, Inc. According to a safety communication sent this week by MedWatch, the FDA's safety information and adverse event reporting program, an FDA sample analysis found the product to contain methocarbamol and diclofenac. The affected Reumofan Plus lots may include lot number 99515 ex096, with an expiration date of 2016. The product is packaged in a green bottle in batches of 30 round lavender tablets. The product is distributed via the Internet. Potentially affected products were sold between February 2012 and June 2012. Customers purchasing the product should have received an email to advise them of their options. Although the manufacturer has not received any reports of related adverse events, "use of this product could result in life-threatening hypersensitivity reactions and anaphylaxis and could cause a temporary and reversible increase in [central nervous system] depression," the FDA notes. The product is used as a treatment for muscle pain, arthritis, osteoporosis, bone cancer, and other conditions. "Consumers that have Reumofan Plus should be aware that the product may pose a health risk and are advised to consult their family doctor/stop using/return to place of purchase or discard," the FDA warns. For products purchased elsewhere, the local FDA office should be contacted. Consumers with questions regarding this recall can contact Samantha Lynn, Inc., by email at naturallifeandhealth@aol.com from Monday to Friday, between 8 am and 5 pm Pacific Standard Time. To report problems with the tables, contact MedWatch, the FDA's safety information and adverse event reporting program, by telephone at 1-800-FDA-1088; by fax at 1-800-FDA-0178; online at www.accessdata.fda.gov/scripts/medwatch/medwatch-online.htm; with postage-paid FDA form 3500, available at www.fda.gov/MedWatch/getforms.htm; or by mail to MedWatch, 5600 Fishers Lane, Rockville, Maryland 20852-9787.
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Post by beebs on Sept 13, 2012 6:02:20 GMT -5
Avoids NSAIDs including Aspirins, fluoroquinolones antibiotics, lariam/mefloquine, and check out other meds, even if anecdotal, if you already suffered from ADRs or suffer cardiovascular issues. A report shows a clear association between Z-Pack (Azithromycin) and risks of heart attacks, from erythromycin, and other meds. Ignore "rare" side effects, they are not, and often manifest one or two years later. The report discusses the heart attack risks higher during the first five days of taking Z-Pack, but from my own experience and observation, it could occur within the first two years. (Mentioned in Aspirin article, about MIs happening long time after taking it) Science Daily......../Azithromycin, commonly called a "Z-pack" is one of the most popular treatments for bacterial sinus infections and bronchitis. Although it was previously considered to carry little to no cardiac risk, the researchers noted well-documented reports in the published literature as FDA database reports linking azithromycin with serious arrhythmias. Based on this evidence, the Vanderbilt researchers sought to examine cardiovascular deaths in patients who were taking the antibiotic www.sciencedaily.com/releases/2012/05/120516174247.htm
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Post by beebs on Sept 24, 2012 16:43:05 GMT -5
I am posting this article here, because it raises a red flag. Vancouver researcher finds flu shot is linked to H1N1 illnessA strange vaccine-related phenomenon spotted in Canada at the start of the 2009 flu pandemic may well have been real, a new study suggests. Researchers, led by Vancouver's Dr. Danuta Skowronski, an influenza expert at the B.C. Centre for Disease Control, noticed in the early weeks of the pandemic that people who got a flu shot for the 2008-09 winter seemed to be more likely to get infected with the pandemic virus than people who hadn't received a flu shot. Five studies done in several provinces showed the same unsettling results. But initially research outside Canada did not, and the effect was dismissed as a "Canadian problem," a problem with the flu vaccine used in Canada. But a new study suggests the findings were real. Skowronski and a group of researchers have recreated the event in ferrets. Their findings were presented Sun-day at the Interscience Conference on Antimicrobial Agents and Chemotherapy, a major international infectious diseases conference taking place in San Francisco.Cont/.... www.vancouversun.com/health/Vancouver+researcher+finds+shot+linked+H1N1+illness/7217609/story.html#ixzz27QRiFAsB
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Post by beebs on Oct 25, 2012 17:59:30 GMT -5
Article in Medscape linking Monster Energy drink to five deaths and a 14 year old girl who died from a heart attack. The FDA is investigating, as they did Red Bull. Several countries banned Red Bull. Monster Energy Drink contains Guarana which contains guaranine (a caffeine), taurine and caffeine. It sounds similar to Red Bull, also associated with sudden deaths. www.medscape.com/viewarticle/773214?src=nldne
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Post by beebs on Oct 25, 2012 18:10:16 GMT -5
Anesthetic topical cream was approved by the FDA. It contains lidocaine and tetracaine. Note it is associated with adverse effects such as headache, fever, vomiting, edema, skin discoloration and erythema. BEWARE. It will be used for superficial aesthetic surgery. www.medscape.com/viewarticle/773122?src=nldne
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Post by beebs on Oct 26, 2012 14:05:02 GMT -5
Fungal Meningitis outbreak from contaminated steroids injections. The CDC & FDA are investigating patients, some suffered strokes triggered by infected steroid injections. Beware if you are undergoing steroid injections therapy in your joints. Symptoms can take a few weeks or longer to develop. Article: www.cdc.gov/HAI/outbreaks/currentsituation/
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Post by beebs on Nov 2, 2012 14:50:57 GMT -5
Public Citizen is petitioning the FDA for black box warning for the following:
ACE inhibitors, ARBs and aliskiren, specific warning for the use of this combo. Known to cause life threatening conditions when used together.
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Post by beebs on Nov 6, 2012 16:20:44 GMT -5
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Post by beebs on Nov 8, 2012 8:39:07 GMT -5
Find out if you are being prescribed unapproved drugs. Some of those prescribed drugs have been on the market for many years!!! Although the FDA offers little real safety and effectiveness in terms of approved drugs, check out your drugs, specifically, if you are on morphine. The article offers little info, as to which drugs to watch out for: www.medscape.com/viewarticle/737615
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Post by beebs on Nov 25, 2012 9:24:47 GMT -5
BMJ accuses ROCHE of concealing data about neuropsychiatrists adverse reactions to the Tamiflu vaccine. it contains neuraminidase inhibitor drug, which are supposed to block reproduction of viral cells. Oddly, Phase 3 of the trial data was never published by Roche. Article: www.medscape.com/viewarticle/774548?src=nldne
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Post by beebs on Dec 16, 2012 16:12:37 GMT -5
Death toll has now reached 36. Contaminated methylprednisolone acetate injections (from NCC), fungal meningitis. Bacillus and fungal species such as "Aspergillus tubingensis, A fumigatus, Cladosporium species, and Penicillium" have been found. Note that clinicians do not know the consequences of infection. www.fda.gov/Drugs/DrugSafety/FungalMeningitis/ucm325037.htm
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Post by beebs on Dec 19, 2012 17:04:08 GMT -5
Oral steroids significant risk of heart attacks by 68% from cummulative usage, and adding 5 mg to present dosage. In a nutshell, the study shows damage to endothelial cells, vascular wall and contractility. This may lead to plaque dislodging. The study focuses on glucosteroids and rheumatoid sufferers. rheumatology.oxfordjournals.org/content/52/1/68.abstract
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Post by beebs on Jan 19, 2013 17:38:13 GMT -5
Four sisters (and 51 other women) filed a law suit against Eli Lily. They developed breast cancer, fertility issues and miscarriages, linked to a drug their mother (and million others) taken during the 1950s called DES. It has also been linked a rare form of vaginal cancer. The drug was removed in 1970s. DES prescribed to prevent miscarriages, which of course, it didn't. Read story: www.startribune.com/lifestyle/health/186207391.html
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