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Post by Admin on Aug 31, 2013 17:31:06 GMT -5
Topical anesthetics. Be aware that topical as in creams, sprays, patches of any medication can be fatal. Taking baths or applying heated pads and so forth, enables the drug to enter the system rapidly, and may cause deaths. This article warns, whilst downplaying statistics. This applies to hormones, nicotine, and any other patches. Remove when taking hot showers/baths, regardless if the dose is low, or covers a small area. Look this up yourselves. FDA MedWatch Issues Alert on Safety of Topical Anesthetics January 16, 2009 — The Food and Drug Administration (FDA) today released a public-health advisory underlining potential life-threatening adverse events from the improper use of topical anesthetics. Improper use includes applying too much, over too large an area, application to broken or irritated skin, or covering the anesthetic with a wrap or heating pad, according to the advisory. "Improper use can lead to excessive absorption of the drug into the bloodstream and may cause life-threatening side effects such as irregular heartbeat, seizures, breathing difficulties, coma, and even death," an accompanying Dear Colleague letter from the Department of Health and Human Services, FDA, undersigned by Theresa Toigo, director of the Office of Special Health Issues, states. In particular, the letter focuses on a study recently published in Radiology looking at the use by women undergoing mammography of topical anesthetics such as lidocaine over large areas of skin and covered with plastic wrap (Lambertz CK et al. Radiology 2008;248:765-772). Results of the study showed significantly less discomfort during mammography with this strategy compared with plain gel or oral acetaminophen or ibuprofen, the FDA release notes. Coint/... www.medscape.com/viewarticle/586987
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Post by Admin on Feb 5, 2015 20:16:03 GMT -5
Anticholergenic drugs can cause dementia even a low dose. Thugh it mentions older adults, it can affect anyone. Look up compounds and pharmacology/dynanics toxicities and side effects. A new study provides the strongest evidence that anticholinergic drugs may increase the risk for dementia in older adults.
The drugs implicated are commonly used, estimated to be taken by about 20% of the older adult population for many conditions. They include popular antihistamines sold over the counter as sleep aids, such as diphenhydramine (Benadryl, McNeil-PPC Inc), or for allergy relief, such as chlorpheniramine; oxybutynin and tolterodine for overactive bladder; and the tricyclic antidepressants, such as doxepin or amitriptyline, even when used at low doses for migraine prevention or neuropathic pain. The study, published online in JAMA Internal Medicine on January 26, was conducted by a team led by Shelly Gray, PharmD, University of Washington, Seattle. "We found an obvious dose-response relationship between anticholinergic drug use and risk of developing dementia: the higher the usage, the greater the risk," Dr Gray commented to Medscape Medical News. Even Low Doses Implicated But people taking just the minimum effective dose of these agents for prolonged periods qualified as having high use and were found to be at greater risk for dementia compared with those not taking such medicines. Cont/... www.medscape.com/viewarticle/838788?src=stfb
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Post by Admin on Jan 25, 2016 19:16:54 GMT -5
Please share widely: Pfizer’s Quiet Recall of Lyrica Capsules January 24, 2016 By Pat Anson, Editor Pfizer has quietly recalled three lots of its blockbuster drug Lyrica because of a manufacturing problem that could have left some capsules deformed or damaged. The voluntary recall only involves 50 mg and 75 mg Lyrica capsules with a certain lot number and expiration date. “Please note that use of, or exposure to, product from these lots is not likely to cause health consequences,” said Lou Dallago, Vice-President of Pfizer’s U.S. Trade Group, in a “Dear Customer” letter sent to retailers who may have received a shipment of the recalled Lyrica lots in September or October 2015. The letter is dated January 11, 2016 and is stamped “Urgent: Drug Recall.” Pfizer has not publicized or notified patients directly about the recall. The drug maker has issued no press releases about the recall and there is no mention of it on Pfizer’s Lyrica website or the Food and Drug Administration's website that lists recalled products. No information is available on the size of the recall or where the potentially defective capsules were shipped. Cont... www.painnewsnetwork.org/stories/2016/1/24/pfizers-quiet-recall-of-lyrica-capsules
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