Post by beebs on May 18, 2011 18:04:36 GMT -5
Several articles with strong supportive evidence as to why some of us suffer excruciating pains and other symptoms following minimal physical exertion, suffering for many days, sometimes months with post-exertional malaise, and that is putting it mildly!!
There will be other posts to support the theory of producing to much lactic acid, and nitric oxide (NO), and rise in reactive oxygen species (ROS).
It also explains why massages can make some of us very ill. Recently, I had a Massage called Dan Xue Tui Na which led me to feeling very ill the following day. This type of massage, works similarly to Acupuncture. SIGH.
Namid posted and article under the Acupuncture thread which shows acupuncture can raise the NO for some, causing even worse symptoms.
In this case, the No Pain No Gain does not apply and can even lead to catastrophic relapses and even more disability.
Pushing yourself by raising your ceiling from your own activites baseline is contraindicated, as I have learned to my own detriment. Lazy? I wish it was that simple!!
This article ties in nicely with other studies in regards to oxidative stress.
J Womens Health (Larchmt). 2010 Jun;19(6):1073-7.
Nitric oxide metabolite production during exercise in chronic fatigue syndrome: a case-control study.
Suárez A, Guillamó E, Roig T, Blázquez A, Alegre J, Bermúdez J, Ventura JL, García-Quintana AM, Comella A, Segura R, Javierre C.
Source
Department of Physiological Sciences II, Medical School, University of Barcelona, L'Hospitalet, Barcelona, Spain.
Abstract
BACKGROUND:
Chronic fatigue syndrome (CFS) is a disabling illness of unknown etiology that is characterized by fatigue associated with a reduced ability to work, lasting for more than 6 months, and accompanied by a specific set of symptoms. The diagnosis remains difficult because of the absence of laboratory tests and is, therefore, made largely on the basis of the symptoms reported by the patient. The aim of this study was to analyze differences in blood nitrate levels in CFS patients and a matched control group after a physical exercise test.
METHODS:
Forty-four consecutive female patients with CFS and 25 healthy women performed an exercise test using a cycle ergometer with monitoring of cardiopulmonary response. Blood samples were obtained for biochemical analyses of glucose, lactate, and nitrates at the beginning (under resting conditions) and after the maximal and supramaximal tests.
RESULTS:
Plasma nitrates differed between the groups, with higher values in the CFS group (F = 6.93, p = 0.003). Nitrate concentration increased in relation to workload and reached higher values in the CFS group, the maximum difference with respect to the control group being 295% (t = 4.88, p < 0.001).
CONCLUSIONS:
The main result of the present study is that nitric oxide (NO) metabolites (nitrates) showed a much higher increase after a maximal physical test in CFS patients than in a group of matched subjects. This combination (exercise plus NO response evaluation) may be useful in the assessment of CFS.
There will be other posts to support the theory of producing to much lactic acid, and nitric oxide (NO), and rise in reactive oxygen species (ROS).
It also explains why massages can make some of us very ill. Recently, I had a Massage called Dan Xue Tui Na which led me to feeling very ill the following day. This type of massage, works similarly to Acupuncture. SIGH.
Namid posted and article under the Acupuncture thread which shows acupuncture can raise the NO for some, causing even worse symptoms.
In this case, the No Pain No Gain does not apply and can even lead to catastrophic relapses and even more disability.
Pushing yourself by raising your ceiling from your own activites baseline is contraindicated, as I have learned to my own detriment. Lazy? I wish it was that simple!!
This article ties in nicely with other studies in regards to oxidative stress.
J Womens Health (Larchmt). 2010 Jun;19(6):1073-7.
Nitric oxide metabolite production during exercise in chronic fatigue syndrome: a case-control study.
Suárez A, Guillamó E, Roig T, Blázquez A, Alegre J, Bermúdez J, Ventura JL, García-Quintana AM, Comella A, Segura R, Javierre C.
Source
Department of Physiological Sciences II, Medical School, University of Barcelona, L'Hospitalet, Barcelona, Spain.
Abstract
BACKGROUND:
Chronic fatigue syndrome (CFS) is a disabling illness of unknown etiology that is characterized by fatigue associated with a reduced ability to work, lasting for more than 6 months, and accompanied by a specific set of symptoms. The diagnosis remains difficult because of the absence of laboratory tests and is, therefore, made largely on the basis of the symptoms reported by the patient. The aim of this study was to analyze differences in blood nitrate levels in CFS patients and a matched control group after a physical exercise test.
METHODS:
Forty-four consecutive female patients with CFS and 25 healthy women performed an exercise test using a cycle ergometer with monitoring of cardiopulmonary response. Blood samples were obtained for biochemical analyses of glucose, lactate, and nitrates at the beginning (under resting conditions) and after the maximal and supramaximal tests.
RESULTS:
Plasma nitrates differed between the groups, with higher values in the CFS group (F = 6.93, p = 0.003). Nitrate concentration increased in relation to workload and reached higher values in the CFS group, the maximum difference with respect to the control group being 295% (t = 4.88, p < 0.001).
CONCLUSIONS:
The main result of the present study is that nitric oxide (NO) metabolites (nitrates) showed a much higher increase after a maximal physical test in CFS patients than in a group of matched subjects. This combination (exercise plus NO response evaluation) may be useful in the assessment of CFS.