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Post by Admin on Mar 22, 2020 1:19:13 GMT -5
More posts will follow concerning natural occurring antiviral properties of some foods and herbs Format: Abstract
Send to Evid Based Complement Alternat Med. 2013;2013:606212. doi: 10.1155/2013/606212. Epub 2013 May 20. The pomegranate: effects on bacteria and viruses that influence human health. Howell AB1, D'Souza DH. Author information www.ncbi.nlm.nih.gov/pubmed/23762148
Abstract
Pomegranates have been known for hundreds of years for their multiple health benefits, including antimicrobial activity. The recent surge in multidrug-resistant bacteria and the possibility of widespread global virus pandemics necessitate the need for additional preventative and therapeutic options to conventional drugs. Research indicates that pomegranates and their extracts may serve as natural alternatives due to their potency against a wide range of bacterial and viral pathogens. Nearly every part of the pomegranate plant has been tested for antimicrobial activities, including the fruit juice, peel, arils, flowers, and bark. Many studies have utilized pomegranate peel with success. There are various phytochemical compounds in pomegranate that have demonstrated antimicrobial activity, but most of the studies have found that ellagic acid and larger hydrolyzable tannins, such as punicalagin, have the highest activities. In some cases the combination of the pomegranate constituents offers the most benefit. The positive clinical results on pomegranate and suppression of oral bacteria are intriguing and worthy of further study. Much of the evidence for pomegranates' antibacterial and antiviral activities against foodborne pathogens and other infectious disease organisms comes from in vitro cell-based assays, necessitating further confirmation of in vivo efficacy through human clinical trials.
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Post by Admin on Mar 22, 2020 3:44:53 GMT -5
See two papers below about the antiviral activities of St John's Wort, on paper discusses possible cytotoxicity: Evaluation of the cytotoxic effect and antibacterial, antifungal, and antiviral activities of Hypericum triquetrifolium Turra essential oils from TunisiaAbstract Background
A number of bio-active secondary metabolites have been identified and reported for several Hypericum species. Many studies have reported the potential use of the plant extracts against several pathogens. However, Hypericum triquetrifolium is one of the least studied species for its antimicrobial activity. The aim of the present study was to evaluate the cytotoxic effect of the essential oils of Hypericum triquetrifolium as well as their antimicrobial potential against coxsakievirus B3 and a range of bacterial and fungal strains.bmccomplementmedtherapies.biomedcentral.com/articles/10.1186/1472-6882-13-24 Modulation of cytokine production from cultured mononuclear cells of leukemia patients by Hypericum triquetrifolium Turra methanolic extract Ali H. Ad’hiah ORCID Icon, Ruqaia M. Ibraheem & Khulood W. AbboodORCID Icon, Ruqaia M. Ibraheem & Khulood W. Abbood Pages 13-19 | Received 01 Dec 2016, Accepted 02 Oct 2017, Accepted author version posted online: 09 Apr 2018, Published online: 18 Apr 2018
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Abstract
The effect of Hypericum triquetrifolium Turra (Family: Hypericaceae) methanolic extract on an in vitro cytokine release (IL-2, IL-4, IL-10, IL-17A and IFN-γ) from cultured mononuclear cells was determined. The cells were obtained from acute lymphoblastic (ALL) and acute myelogenous leukemic (AML) Iraqi patients. Two concentrations (1.146 and 1.719 µg/ml) of the extract were tested. They were correspondent to 20 and 30%, respectively of the plant IC50 (5.73 µg/ml). Chemical analysis of the extract showed its richness in flavonoids (115.73 µg/ml). Assessments of cytokine levels in supernatants of cultured cells revealed that ALL, AML or control cells responded differently to the plant extract in their production of IL-2, IL-10, IL-17A and IFN-γ, but leukemic cells were better than control cells in their response, while there was no effect on IL-4 production. The results suggested that H. triquetrifolium methanolic extract exerted immunomodulatory effects on cultured cells. www.tandfonline.com/doi/full/10.1080/25765299.2018.1449413
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Post by Admin on Mar 22, 2020 5:40:22 GMT -5
Published paper discusses various antivirals. Copied and pasted the paragraph concerning Coronavirus: Excerpt from Antiviral Natural Products and Herbal Medicines Liang-Tzung Lin,1 Wen-Chan Hsu,2 and Chun-Ching Lin2 Author information Copyright and License information Disclaimer"We have previously reported that saikosaponins (A, B2, C, and D), which are naturally occurring triterpene glycosides isolated from medicinal plants such as Bupleurum spp. (柴胡 Chái Hú), Heteromorpha spp., and Scrophularia scorodonia (玄參 Xuán Shēn), exert antiviral activity against HCoV-22E9.[14] Upon co-challenge with the virus, these natural compounds effectively prevent the early stage of HCoV-22E9 infection, including viral attachment and penetration. Extracts from Lycoris radiata (石蒜 Shí Suàn), Artemisia annua (黃花蒿 Huáng Huā Hāo), Pyrrosia lingua (石葦 Shí Wěi), and Lindera aggregata (烏藥 Wū Yào) have also been documented to display anti–SARS-CoV effect from a screening analysis using hundreds of Chinese medicinal herbs.[15] Natural inhibitors against the SARS-CoV enzymes, such as the nsP13 helicase and 3CL protease, have been identified as well and include myricetin, scutellarein, and phenolic compounds from Isatis indigotica (板藍根 Bǎn Lán Gēn) and Torreya nucifera (榧 Fěi).[16,17,18] Other anti-CoV natural medicines include the water extract from Houttuynia cordata (魚腥草 Yú Xīng Cǎo), which has been observed to exhibit several antiviral mechanisms against SARS-CoV, such as inhibiting the viral 3CL protease and blocking the viral RNA-dependent RNA polymerase activity.[19]" www.ncbi.nlm.nih.gov/pmc/articles/PMC4032839/
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Post by Admin on Mar 22, 2020 7:04:34 GMT -5
Info regarding natural antiviral such as from Green Tea, Ginseng, Echinacea and more. Be cautious and beware of causing issues with over active immune system which carries serious health issues:
Excerpt from article:
Evid Based Complement Alternat Med. 2005 Dec; 2(4): 513–520. Published online 2005 Oct 20. doi: 10.1093/ecam/neh125 PMCID: PMC1297498 PMID: 16322809 Natural Health Products, Modulation of Immune Function and Prevention of Chronic Diseases Pierre S. Haddad,1,2,5,* Georges A. Azar,3 Simon Groom,4 and Michel Boivin1,5 Author information Article notes Copyright and License information Disclaimer
NHPs having Immunomodulatory Activity
During the last century, modern medicine has contributed major advancements to sanitation and public health initiatives and discoveries like antibiotics and vaccination. These efficiently hindered the progression of infectious diseases through the population. In fact, modern medicine has succeeded best in treating acute illnesses. It is in the realm of chronic diseases that modern medicine and drugs have been more disappointing and that NHPs have elicited resurgent interest. In this section, we review the evidence for the immunomodulatory action of several NHPs, including probiotics, products of animal origin (principally milk and thymic extracts), nutritional factors (especially vitamins, minerals and fatty acids) and herbal products. Table 3 summarizes the strongest evidence brought forward for some of the most promising NHPs. Readers are also oriented to recent reviews (37,38) for complementary information.www.ncbi.nlm.nih.gov/pmc/articles/PMC1297498/
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