Post by beebs on Aug 13, 2012 12:38:10 GMT -5
Two of many published articles about the benefits
of Nattokinase, extracted from fermented soy, which
the Japanese call Natto. Hence, a lower incidence
of blood clots leading to myocardial infarction.
I have been taking Natto for two months, and will
now take Serrapeptase, anti inflammatory, mops
up plaque and other benefits.
Microbial fibrinolytic enzymes: an overview of source, production, properties, and thrombolytic activity in vivo.
Peng Y, Yang X, Zhang Y.
Source
College of Life Sciences, Sichuan University, Chengdu, PR China.
Abstract
Accumulation of fibrin in the blood vessels usually results in thrombosis, leading to myocardial infarction and other cardiovascular diseases. For thrombolytic therapy, microbial fibrinolytic enzymes have now attracted much more attention than typical thrombolytic agents because of the expensive prices and the undesirable side effects of the latter. The fibrinolytic enzymes were successively discovered from different microorganisms, the most important among which is the genus Bacillus from traditional fermented foods. The physiochemical properties of these enzymes have been characterized, and their effectiveness in thrombolysis in vivo has been further identified. Therefore, microbial fibrinolytic enzymes, especially those from food-grade microorganisms, have the potential to be developed as functional food additives and drugs to prevent or cure thrombosis and other related diseases.
www.ncbi.nlm.nih.gov/pubmed/16211381
Nutrition. 2003 Mar;19(3):261-4.
Dietary supplementation with fermented soybeans suppresses intimal thickening.
Suzuki Y, Kondo K, Ichise H, Tsukamoto Y, Urano T, Umemura K.
Source
Department of Pharmacology, Hamamatsu University School of Medicine, Shizuoka, Japan. yapplel@hama-med.ac.jp
Abstract
Although soy foods have been consumed for more than 1000 y, it is only in the past 20 y that they have made inroads into Western diets. We investigated the effect of dietary supplementation with natto extracts produced from fermented soybeans on intimal thickening of arteries after vessel endothelial denudation. Natto extracts include nattokinase, a potent fibrinolytic enzyme having four times greater fibrinolytic activity than plasmin. Intimal thickening was induced in the femoral arteries by intravenous infusion of rose bengal followed by focal irradiation with a transluminal green light. Dietary natto extract supplementation was started 3 wk before endothelial injury and continued for another 3 wk after. In ex vivo studies, euglobulin clot lysis times were measured 3 wk after the initial supplementation. Neointima formation and thickening were also initiated successfully. The intima media ratio 3 wk after endothelial injury was 0.15 +/- 0.03 in the control group. Dietary natto extract supplementation suppressed intimal thickening (0.06 +/- 0.01; P < 0.05) compared with the control group. Natto extracts shortened euglobulin clot lysis time, suggesting that their thrombolytic activities were enhanced. These findings suggest that natto extracts, because of their thrombolytic activity, suppress intimal thickening after vascular injury as a result of the inhibition of mural thrombi formation. www.ncbi.nlm.nih.gov/pubmed/12620531