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Post by Admin on Apr 21, 2011 17:49:49 GMT -5
Wanted to share how simple it was, once, I found out how to treat!! None of the doctors, mitochondria nuerologist, nutritionists, and so called experts, helped in any way!!! I had a test for mitochondrial function a few years ago. It showed dysfunction in ATP/ADP. Weak and multiple symptoms. Intolerance to heat and cold weather, inability to go more than three hours without eating and so forth. One distressing symptoms in particular, was a feeling of the heart going into spasms, vibrating, just as with muscles fascuculations (twitches). It could have been caused by malnutrition resulting from a very limited diet. It was worrying. I read about some who died with this. Apparently, for some, it was caused by very low magnesium or other nutrients. I tried Magnesium Orotate, although this helped with the heart failure, and some arrythmias, it didn't stop the heart spasms. I tried L-Carnitine after reading an article published in PubMed, that this can help with arrythmias (also have atrial flutter, AFib, and SVT, tachycardia). It didn't help for long. I tried several brands of amino acids, but could tolerate none. One of the symptoms was having to eat large amount of lamb everyday. This brought up the serum ferritin, which caused other health issues. Lamb is high in amino acids, in particular, L-Carnitine. I started on Pea Protein powder two weeks ago. Zero heart spams. I eat a few spoonfuls daily. There is much improvement, which could be attributed to nutrients, including high amount of amino acids.
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Post by psychessearch on Apr 21, 2011 18:11:10 GMT -5
Interesting! This sounds like something that may help me. I suspect a mitrochondrial problem in me. I had tachycardia several months ago but took iron for awhile. 3 questions:
- Did you have low serum ferratin? - Can you recommend any particular website and/or brand? - can you point me to any good info about mitochondrial problems?
Thank you.
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Post by Admin on Apr 21, 2011 18:36:25 GMT -5
Interesting! This sounds like something that may help me. I suspect a mitrochondrial problem in me. I had tachycardia several months ago but took iron for awhile. 3 questions: - Did you have low serum ferratin? - Can you recommend any particular website and/or brand? - can you point me to any good info about mitochondrial problems? Thank you. Did the Iron help with the tachy? My serum ferritin is too high, as is the haemoglobin. I am also low on folate, this cascades in other symptoms, which raised my homocyestine level. The CPK is slightly elevated. All this, shows inflammatory process which should be reversed, or halted. I am taking yellow split pea Pulsin (in the UK) www.pulsin.co.uk/protein-powders/pea-protein-isolate.html and ordered this one, higher in nutrients: www.naturesbest.co.uk/pea-protein-90-p350/?src=goaaoo as well as Organic Hemp Seed Oil and Hemp Protein Powder: www.thehempshop.co.uk. (no affiliation or financial interest with those companies). As for mitochondria, will post the info tomorrow, a useful Yahoo group. There are several mito sites. Extremely difficult to diagnose. Tests are unreliable. The point, is, mitochondrial diseases which are often portrayed as genetic, and little mention of "acquired", caused by meds, and other such as infections. There is much debates about "genetic', since there are very few diseases which are truly genetic. It could be mutations caused by vaccines, meds taken by pregnant mothers etc.. Mito science is in its infancy. There is little doubt that that meds causes damage to mitochondria, causing chronic diseases and ill health as mentioned in"Welcome to Newbies" post. There will be posts about some medications causing Parkinson and more during the next few weeks.
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Post by ernestoshoney on May 1, 2011 5:10:15 GMT -5
Hi guys, How would one go about getting tested for mitochondrial dysfunction? And is there anything that can be done for it? Or can it just go away on it's own?
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Post by beebs on May 1, 2011 7:31:03 GMT -5
Mito tests are a maze of low specificity and unreliable series of DNA tests, muscle biopsies, immunohistological, lactic acid etc... My neuro did some tests already. Interpretation of tests is abysmal. ,Glycation often shown on results. There is no known cure, except for vits and supps for most of those "acquired" mito diseases, medications being a MAJOR contribution, also see the abstracts on the Welcome page. Take a look at those sites below, I will post the info from medical journals under mitochondria thread and how it affects us. Some of can't metabolize fatty acids, or the L-Carnitine pathway is dysfunctional etc.. all related to meds!! Scientific reserach focuses more on genetic rather than acquire, as to be politcally correct. Meanwhile, more and more papers being published about mito myopathies induced by medications. Look up Mito support sites, it will show how difficult it is diagnose. neuromuscular.wustl.edu/mitosyn.htmlaaemonline.org/blog/2009/02/03/medication-induced-mitochondrial-damage-and-disease/www.medicalinsider.com/mitochondrial.htmlMitochondrial dysfunction is increasingly implicated in the etiology of drug-induced toxicities. Members of diverse drug classes undermine mitochondrial function, and among the most potent are drugs that have been withdrawn from the market, or have received Black Box warnings from the FDA. To avoid mitochondrial liabilities, routine screens need to be positioned within the drug-development process. Assays for mitochondrial function, cell models that better report mitochondrial impairment, and new animal models that more faithfully reflect clinical manifestations of mitochondrial dysfunction are discussed in the context of how such data can reduce late stage attrition of drug candidates and can yield safer drugs in the future. www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T64-4PGH4KM-2&_user=10&_rdoc=1&_fmt=&_orig=search&_sort=d&view=c&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=2b0f2c01c4febb80796bf35e0f29bb42
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Post by beebs on May 3, 2011 9:02:51 GMT -5
Forgot to add that, eating high protein food, and in particular, pea protein, high in amino acids helped with weakness and breathlessness.
Until I was able to tolerate pea proein, (about two weeks ago), I tried several brands of amino acids. Could only tolerate L-Carnitine from Lambert's. I had to eat large quantity of lamb rarely beef daily in order not to collapse.
Apparently, CoQ 10 helps, but it triggered tachy with me. Magnesium helps too. The protocol I was given for the mito dysfunction is as follows:
(Based on my test results for ADP to ATP conversion)
Magnesium Malate (I prefer Orotate in its pure form) Magnesium injection (didn't) Methyl B12 5000 mcg (took some) B12 injections (not) D-Ribose (tried, made heart speed, found out recently many can't tolerate and can cause more damage) Q10 (not) Vit B3 (allergic, but eating foods high in Niacin without probs) Ox-Ogenol (not) Acetyl L Carnitine (was very helpful) SpdZyme (not yet) Vit E (could not find one NOT derived from Soya) Zinc citrate (tried and helped) Complete EFA (can't tolerate, only from some foods)
This protocol or some of the supps might help...
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