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Post by beebs on Jul 27, 2012 10:08:14 GMT -5
Not tried cannabis therapy, read a lot, and spoke to those who are seriously ill, and recovered. To clarify when researching. Read up on CBD and THC A, (non psychoactive). THC is psychoactive when heated, either smoking, or cooking. Sativex is unfortunately psychoactive. It contains equal amount of CBD and psychoactive THC. Patients prefer to prepare their own oil. Most Hybrids contain high level of THC - demand high. Increasing demand from patients for Indica and other hybrids which contains high CBD compounds. When looking up scientific research, look up CBD, Cannabidiol compounds and THC A, if you look up cannabis, there are hundreds of article, about the psychoactive effects, these are of no concern and no interest, hardly mention of Tetrahydrocannabivarin (psychoactive) in abstracts. Articles need to be specific. I will post links to relevant research. Over 30,000 published scientific papers. CBD was largely ignored until recently. Both CBD and THC have been found to reverse cancer. THC and CBD (and unknown compounds) when combined are therapeutic for cancer, immune system, anti oxidative, anti inflammatory, neuroprotective etc.. Discussed with medical cannabis users, leaning towards using an oil or tincture which contains equal amount of THC A and CBD, others prefer to buy them separately and experiment which is most helpful. I spoke to cancer and AIDS Stage III patient, lupus sufferer, epileptic patients, thyroid issues. All recovered. There is a need to disassociate smoking pot with cannabis, associate instead juicing fresh leaves and the medicinal oil. Cannabis finally demonized? ;D First two YT vids are basic, the third shows shows the neuronal circuitry and importance of endoccanabinoid system, scientists neglecting, denying its importance until recently. It seems almost by design!! As for approval in the mainstream, don't hold your breath, it will not happen...It has been known since, 1974, that cannabis has the potential to kill cancer cells. Cancer patient on average brings in $300,000 for Big Pharma, depending on how long they live. Ayurvedic & TCM doctors have used cannabis treating various ills for thousands of years. [youtube] www.youtube.com/watch?v=9gOYVJu__14&feature=related[/youtube]The paper below discusses the potential for curing breast cancer. Others have used it to treat their prostate, lung and other cancers successfully. Cancer Treat Rev. 2012 Jul 7. [Epub ahead of print] Cannabinoids: A new hope for breast cancer therapy?Caffarel MM, Andradas C, Pérez-Gómez E, Guzmán M, Sánchez C. Source Dept. Biochemistry and Molecular Biology I, School of Biology, Complutense University-CIBERNED-IRYCIS, Madrid, Spain. Abstract Breast cancer is a very common disease that affects approximately 1 in 10 women at some point in their lives. Importantly, breast cancer cannot be considered a single disease as it is characterized by distinct pathological and molecular subtypes that are treated with different therapies and have diverse clinical outcomes. Although some highly successful treatments have been developed, certain breast tumors are resistant to conventional therapies and a considerable number of them relapse. Therefore, new strategies are urgently needed, and the challenge for the future will most likely be the development of individualized therapies that specifically target each patient's tumor. Experimental evidence accumulated during the last decade supports that cannabinoids, the active components of Cannabis sativa and their derivatives, possess anticancer activity. Thus, these compounds exert anti-proliferative, pro-apoptotic, anti-migratory and anti-invasive actions in a wide spectrum of cancer cells in culture. Moreover, tumor growth, angiogenesis and metastasis are hampered by cannabinoids in xenograft-based and genetically-engineered mouse models of cancer. This review summarizes our current knowledge on the anti-tumor potential of cannabinoids in breast cancer, which suggests that cannabinoid-based medicines may be useful for the treatment of most breast tumor subtypes.
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Post by beebs on Jul 27, 2012 10:15:07 GMT -5
Paper discuss cannabis and cancer:
Int J Oncol. 2012 Aug;41(2):407-13. doi: 10.3892/ijo.2012.1476. Epub 2012 May 14. Cannabinoid-associated cell death mechanisms in tumor models (Review). Calvaruso G, Pellerito O, Notaro A, Giuliano M. Source
Department of Experimental Biomedicine and Clinical Neuroscience, Section of Biochemical Sciences, University of Palermo, 90129 Palermo, Italy. Abstract
In recent years, cannabinoids (the active components of Cannabis sativa) and their derivatives have received considerable interest due to findings that they can affect the viability and invasiveness of a variety of different cancer cells. Moreover, in addition to their inhibitory effects on tumor growth and migration, angiogenesis and metastasis, the ability of these compounds to induce different pathways of cell death has been highlighted. Here, we review the most recent results generating interest in the field of death mechanisms induced by cannabinoids in cancer cells. In particular, we analyze the pathways triggered by cannabinoids to induce apoptosis or autophagy and investigate the interplay between the two processes. Overall, the results reported here suggest that the exploration of molecular mechanisms induced by cannabinoids in cancer cells can contribute to the development of safe and effective treatments in cancer therapy.
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Post by beebs on Aug 10, 2012 17:41:39 GMT -5
Two articles dicsuss cannabionoids receptors. Sadly, these were discovered in the 1980s, thought to be redundant. Reports in the media and health forums, show cancer remission and cure from using Oil of Cannabis. The scientific community published articles with supporting evidence of cannabis causingcancerous tumor cell death. Its unclear of the ratio of THC/CBD/other compounds for this. There have been verifiable reports of remission/cure of epilepsy, MS, autoimmune diseases, CNS, and more from juicing and/or taking the oil, and milk. Curr Med Chem. 2003 Dec;10(24):2719-32. Cannabinoids: mechanisms and therapeutic applications in the CNS. Drysdale AJ, Platt B.Source Department of Biomedical Sciences, University of Aberdeen, Institute of Medical Sciences, Foresterhill, Aberdeen, AB25 2ZD, Scotland, UK. b.platt@abdn.ac.uk Abstract Cannabinoids comprise three classes of compounds, the active components of marijuana (Cannabis sativa), as well as endogenous and synthetic derivatives. To date, two distinct cannabinoid receptors (CB1 and CB2) have been discovered, but evidence for further receptor types has been brought forward. The potential use of cannabinoids for medicinal purposes has long been known, but the mechanisms of action of both exogenously applied and endogenous cannabinoids are only partly established. For nervous system disorders, cannabinoids may be useful by modulating neurotransmission and calcium homeostasis as well as by anti-inflammatory and anti-oxidant actions. Some cannabinoids can also trigger cell death, which may be of therapeutic benefit in the treatment of malignant tumours. A number of both in vitro and in vivo models have provided promising but diverse evidence for cannabinoid protection in glutamate-mediated excitotoxicity, hypoxia and glucose deprivation, brain trauma, epilepsy and MS. Subsequent to many preclinical investigations, clinical trials are now underway in a variety of the above applications. Overall, the understanding of the therapeutic relevance of cannabinoids will rely on further investigations into the neuroprotective and neurotoxic potency of cannabinoids in animal models and humans, as much as on a further advancement of our general understanding of the endocannabinoid system and the development of specific compounds devoid of unwanted psychoactive side effects. www.ncbi.nlm.nih.gov/pubmed/14529462Int Rev Neurobiol. 2009;88:335-69. Cannabinoid receptors in brain: pharmacogenetics, neuropharmacology, neurotoxicology, and potential therapeutic applications.Onaivi ES. Source Department of Biology, William Paterson University, Wayne, New Jersey 07470, USA. Abstract Much progress has been achieved in cannabinoid research. A major breakthrough in marijuana-cannabinoid research has been the discovery of a previously unknown but elaborate endogenous endocannabinoid system (ECS), complete with endocannabinoids and enzymes for their biosynthesis and degradation with genes encoding two distinct cannabinoid (CB1 and CB2) receptors (CBRs) that are activated by endocannabinoids, cannabinoids, and marijuana use. Physical and genetic localization of the CBR genes CNR1 and CNR2 have been mapped to chromosome 6 and 1, respectively. A number of variations in CBR genes have been associated with human disorders including osteoporosis, attention deficit hyperactivity disorder (ADHD), posttraumatic stress disorder (PTSD), drug dependency, obesity, and depression. Other family of lipid receptors including vanilloid (VR1) and lysophosphatidic acid (LPA) receptors appear to be related to the CBRs at the phylogenetic level. The ubiquitous abundance and differential distribution of the ECS in the human body and brain along with the coupling to many signal transduction pathways may explain the effects in most biological system and the myriad behavioral effects associated with smoking marijuana. The neuropharmacological and neuroprotective features of phytocannabinoids and endocannabinoid associated neurogenesis have revealed roles for the use of cannabinoids in neurodegenerative pathologies with less neurotoxicity. The remarkable progress in understanding the biological actions of marijuana and cannabinoids have provided much richer results than previously appreciated cannabinoid genomics and raised a number of critical issues on the molecular mechanisms of cannabinoid induced behavioral and biochemical alterations. These advances will allow specific therapeutic targeting of the different components of the ECS in health and disease. This review focuses on these recent advances in cannabinoid genomics and the surprising new fundamental roles that the ECS plays in the retrograde signaling associated with cannabinoid inhibition of neurotransmitter release to the genetic basis of the effects of marijuana use and pharmacotherpeutic applications and limitations. Much evidence is provided for the complex CNR1 and CNR2 gene structures and their associated regulatory elements. Thus, understanding the ECS in the human body and brain will contribute to elucidating this natural regulatory mechanism in health and disease. www.ncbi.nlm.nih.gov/pubmed/19897083
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Post by beebs on Aug 13, 2012 13:14:39 GMT -5
The vid was on national news in the US Medical cannabis is widely to treat cancers, autoimmune illnesses, and other illnesses due to its high antiinflammatory properties, anti mutagenic, and more. Big Pharma muscled in, patented THC & CBD compounds... In spite of this, patients taking the oil, milk, and juicing leaves regaining health. Big Pharma is already manufacturing drugs using cannabis, and synthetic compounds in certain drugs. Deliberate hurdles and jumping through hoops, delays further studies. If cancer patients opted for cannabis instead of chemo, Big Pharma would suffer massive loss, oncologists, nurses....you get the picture? Warning: before trying medicinal cannabis, do your homework, read about the ratio of CBD & THC for your own medical issues. Its about trial and error, and what suits your own unique metabolism. Googling cannabis cure cancers will yield several articles [youtube]in the news. www.youtube.com/watch?v=4ypbNYYMPXg&feature=player_embedded#! [/youtube]
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Post by beebs on Aug 21, 2012 16:41:52 GMT -5
Watch out self medicating with medical cannabis without doing your investigative homework and guidance. Considering its therapeutic usage is new in terms of scientific research, (in the West) chemical compounds, anti cancer, anti inflamma, mopping up free radicals etc.. there are hundreds of hybrids and pure breeds. Read more here: www.drugs.com/clinical_trials/medical-marijuana-inc-patent-pending-extraction-cannabidiol-cbd-possible-anti-tumor-anti-cancer-12288.htmlIll advised to self medicate, and choose a breed high in THC compounds because its psychoactive, and may exacerbate CNS symptoms or neuronal damage. In contrast, cannabis containing CBD acts as an anxiolytic. For most, it will be trial and error, tweaking dosages, mixing the appropriate ratio of THC and CBD, choosing safe lab tested oils, sprays, or tincture, under the guidance of physician. This site contains important info: www.greenbridgemed.com/#cf_field_2
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Post by beebs on Sept 9, 2012 10:30:03 GMT -5
Note the paper discussed CBD compounds being anti depressive, although it focuses on 5-HTA1A receptors, its much complex that this.
Br J Pharmacol. 2010 Jan;159(1):122-8. Epub 2009 Dec 4. Antidepressant-like effects of cannabidiol in mice: possible involvement of 5-HT1A receptors Zanelati TV, Biojone C, Moreira FA, Guimarães FS, Joca SR. Source
Department of Pharmacology, School of Medicine of Ribeirão Preto, University of São Paulo, Ribeirão Preto, SP, Brazil. Abstract BACKGROUND AND PURPOSE:
Cannabidiol (CBD) is a non-psychotomimetic compound from Cannabis sativa that induces anxiolytic- and antipsychotic-like effects in animal models. Effects of CBD may be mediated by the activation of 5-HT(1A) receptors. As 5-HT(1A) receptor activation may induce antidepressant-like effects, the aim of this work was to test the hypothesis that CBD would have antidepressant-like activity in mice as assessed by the forced swimming test. We also investigated if these responses depended on the activation of 5-HT(1A) receptors and on hippocampal expression of brain-derived neurotrophic factor (BDNF). EXPERIMENTAL APPROACH:
Male Swiss mice were given (i.p.) CBD (3, 10, 30, 100 mg*kg(-1)), imipramine (30 mg*kg(-1)) or vehicle and were submitted to the forced swimming test or to an open field arena, 30 min later. An additional group received WAY100635 (0.1 mg*kg(-1), i.p.), a 5-HT(1A) receptor antagonist, before CBD (30 mg*kg(-1)) and assessment by the forced swimming test. BDNF protein levels were measured in the hippocampus of another group of mice treated with CBD (30 mg*kg(-1)) and submitted to the forced swimming test. KEY RESULTS:
CBD (30 mg*kg(-1)) treatment reduced immobility time in the forced swimming test, as did the prototype antidepressant imipramine, without changing exploratory behaviour in the open field arena. WAY100635 pretreatment blocked CBD-induced effect in the forced swimming test. CBD (30 mg*kg(-1)) treatment did not change hippocampal BDNF levels. CONCLUSION AND IMPLICATIONS:
CBD induces antidepressant-like effects comparable to those of imipramine. These effects of CBD were probably mediated by activation of 5-HT(1A) receptors.
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Post by beebs on Sept 9, 2012 10:33:33 GMT -5
The first post on this thead has been modified, and clarified. An easy to read article based on published research: ezinearticles.com/?Medical-Properties-Of-Medical-Marijuana&id=6343370This paper discusses liver and use of cannabis: Br J Pharmacol. 2011 Apr;162(7):1650-8. doi: 10.1111/j.1476-5381.2010.01179.x. Cannabidiol improves brain and liver function in a fulminant hepatic failure-induced model of hepatic encephalopathy in mice. Avraham Y, Grigoriadis N, Poutahidis T, Vorobiev L, Magen I, Ilan Y, Mechoulam R, Berry E. Source Department of Human Nutrition and Metabolism, Braun School of Public Health, Hadassah-Hebrew University Medical School, Jerusalem, Israel. yosefa@md.huji.ac.il Abstract BACKGROUND AND PURPOSE: Hepatic encephalopathy is a neuropsychiatric disorder of complex pathogenesis caused by acute or chronic liver failure. We investigated the effects of cannabidiol, a non-psychoactive constituent of Cannabis sativa with anti-inflammatory properties that activates the 5-hydroxytryptamine receptor 5-HT(1A) , on brain and liver functions in a model of hepatic encephalopathy associated with fulminant hepatic failure induced in mice by thioacetamide. EXPERIMENTAL APPROACH: Female Sabra mice were injected with either saline or thioacetamide and were treated with either vehicle or cannabidiol. Neurological and motor functions were evaluated 2 and 3 days, respectively, after induction of hepatic failure, after which brains and livers were removed for histopathological analysis and blood was drawn for analysis of plasma liver enzymes. In a separate group of animals, cognitive function was tested after 8 days and brain 5-HT levels were measured 12 days after induction of hepatic failure. KEY RESULTS: Neurological and cognitive functions were severely impaired in thioacetamide-treated mice and were restored by cannabidiol. Similarly, decreased motor activity in thioacetamide-treated mice was partially restored by cannabidiol. Increased plasma levels of ammonia, bilirubin and liver enzymes, as well as enhanced 5-HT levels in thioacetamide-treated mice were normalized following cannabidiol administration. Likewise, astrogliosis in the brains of thioacetamide-treated mice was moderated after cannabidiol treatment. CONCLUSIONS AND IMPLICATIONS: Cannabidiol restores liver function, normalizes 5-HT levels and improves brain pathology in accordance with normalization of brain function. Therefore, the effects of cannabidiol may result from a combination of its actions in the liver and brain.
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Post by Admin on Sept 14, 2012 5:40:58 GMT -5
Reviewing papers in regards to medicinal cannabis. Many report health benefits, cancer cured, and other health issues recovery. There is a new study showing mariju smokers are at higher risk of testicular cancer. I found contradictory study which shows the opposite, spoke to those who cured their cancers and other illnesses, including AIDS Stage III using CBD & THC oil. Is this posturing and strategy to discourage from prevention & cure? Each cancer patient is worth $300,000 in terms of treatment, whereas taking the oil containing CBD & THC or THC A, costs about $80 per month. Huge dent in Big Pharma's financial portfolio! Note that juiced leaves and oil DO NOT contain psychoactive THC, unless leaves a are dried, or its heated. THC A is NOT psychoactive. Best to avoid prescriptions of Sativex because, its contains THC which is psychoactive!!! The abstract below does not diffenrentiate between CBD compounds which are relaxing and non psychoactive, and THC & THC A, non psychoactive. Medical lit focuses on negative side effects of THC not THC A a new wave of scientists are exploring the medicinal effects and cannabinoids receptors. It has been used for centuries by Ayurvedic doctors, successfully. As for treating dystonia, it does not mention in which form or the potency. Similar studies show benefits for Huntington Disease. [Medical cannabis: the opportunity versus the temptation]. [Article in Hebrew] Naftali T. Abstract The cannabis plant has been known to humanity for centuries as a remedy for pain, diarrhea, and inflammation. Current research has shown cannabis to be a useful remedy for many diseases, including multiple sclerosis, dystonia, and chronic pain. Cannabinoids are used to improve food intake in anorexia of AIDS patients and to prevent vomiting due to cancer chemotherapy. In inflammatory conditions cannabinoids improve pain in rheumatoid arthritis and pain and diarrhea in Crohn's disease. Cannabinoids reduce the size of brain infarct and cardiac reperfusion injury. However, cannabinoid treatment is not free of side effects including [ this happens only when THC is heated] euphoria, psychosis, anxiety, paranoia, dependence and abuse. Since the cannabinoid system is involved in many physiological and pathological processes, the therapeutic potential is great. We must not be blind to the opportunity offered to us by medical cannabis just because it is an illicit drug, nor should we be temped by the quick response of patients to the central effect of cannabis. More research is warranted to explore the full potential of cannabis as medicine. www.ncbi.nlm.nih.gov/pubmed/22352284
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Post by Admin on Sept 16, 2012 9:39:23 GMT -5
See article, clarifying the difference between CBDs, THC, & THC A compounds which is non psychoactive. The <<wink>> <<wink>> attitude - its association with smoking weed, is an hindrance for seriously ill patients. Two completely different effects here, depending on what is being used and how. Accessibility to club drugs, bars, night clubs, raves, and on streets and markets in certain areas of the city, buying magic mushrooms in town markets are easier, than accessing medicinal cannabis oils/tinctures. Smoking pot, a legacy of the 60s generation, created a huge demand for high THC psychoactive cultivation, thus setting aside strains with high CBD content, which is non psychoactive. THC is only psychoactive when heated. Sadly, this led to medical benefits of CBD and THC A largely ignored. This thread concerns seriously ill people who are desperate to access cannabis with contains powerful anti inflammatory compounds capable of reversing ill health. Cruel irony, easier to access weed to smoke than medical oils/tinctures. British Medical Activists are quoted as saying that many are dying unnecessarily. Curious. Most people will ingest dangerous, toxic meds, rather than juicing raw leaves with high CBD & THC A (non psychoactive). It will be inaccessible soon, precisely, because of its therapeutic effects. Big Pharma will have a monopoly. incidentally, already patented are CBD and THC compounds. Manufactured for pain and spaticity, Sativex, is useless. It contains CBD & THC, (psychoactive) and who knows what synthetics. Its extracted from other synergistic compounds! Although cannabis may not cure everyone, the success rate is higher than with anything else I have come across. Enuf said. Pharmacol Ther. 2012 Jan;133(1):79-97. Epub 2011 Sep 6. Phytocannabinoids as novel therapeutic agents in CNS disorders. Hill AJ, Williams CM, Whalley BJ, Stephens GAbstract The Cannabis sativa herb contains over 100 phytocannabinoid (pCB) compounds and has been used for thousands of years for both recreational and medicinal purposes. In the past two decades, characterisation of the body's endogenous cannabinoid (CB) (endocannabinoid, eCB) system (ECS) has highlighted activation of central CB(1) receptors by the major pCB, Δ(9)-tetrahydrocannabinol (Δ(9)-THC) as the primary mediator of the psychoactive, hyperphagic and some of the potentially therapeutic properties of ingested cannabis. Whilst Δ(9)-THC is the most prevalent and widely studied pCB, it is also the predominant psychotropic component of cannabis, a property that likely limits its widespread therapeutic use as an isolated agent. In this regard, research focus has recently widened to include other pCBs including cannabidiol (CBD), cannabigerol (CBG), Δ(9)tetrahydrocannabivarin (Δ(9)-THCV) and cannabidivarin (CBDV), some of which show potential as therapeutic agents in preclinical models of CNS disease. Moreover, it is becoming evident that these non-Δ(9)-THC pCBs act at a wide range of pharmacological targets, not solely limited to CB receptors. Disorders that could be targeted include epilepsy, neurodegenerative diseases, affective disorders and the central modulation of feeding behaviour. Here, we review pCB effects in preclinical models of CNS disease and, where available, clinical trial data that support therapeutic effects. Such developments may soon yield the first non-Δ(9)-THC pCB-based medicines. www.ncbi.nlm.nih.gov/pubmed/21924288
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Post by beebs on Sept 22, 2012 17:26:56 GMT -5
Published in The Huff today, its a little too late for sufferers denied of this wonderful oil. Known as early as 1974, so, what's behind this sudden acknowledgment? Watch the vids: Marijuana And Cancer: Scientists Find Cannabis Compound Stops Metastasis In Aggressive Cancers ......../ Marijuana And Cancer A pair of scientists at California Pacific Medical Center in San Francisco has found that a compound derived from marijuana could stop metastasis in many kinds of aggressive cancer, potentially altering the fatality of the disease forever. "It took us about 20 years of research to figure this out, but we are very excited," said Pierre Desprez, one of the scientists behind the discovery, to The Huffington Post. "We want to get started with trials as soon as possible." The Daily Beast first reported on the finding, which has already undergone both laboratory and animal testing, and is awaiting permission for clinical trials in humans. Desprez, a molecular biologist, spent decades studying ID-1, the gene that causes cancer to spread. Meanwhile, fellow researcher Sean McAllister was studying the effects of Cannabidiol, or CBD, a non-toxic, non-psychoactive chemical compound found in the cannabis plant. Finally, the pair collaborated, combining CBD and cells containing high levels of ID-1 in a petri dish. "What we found was that his Cannabidiol could essentially 'turn off' the ID-1," Desprez told HuffPost. The cells stopped spreading and returned to normal. "We likely would not have found this on our own," he added. "That's why collaboration is so essential to scientific discovery." Desprez and McAllister first published a paper about the finding in 2007. Since then, their team has found that CBD works both in the lab and in animals. And now, they've found even more good news. "We started by researching breast cancer," said Desprez. "But now we've found that Cannabidiol works with many kinds of aggressive cancers--brain, prostate--any kind in which these high levels of ID-1 are present." Cont/... www.huffingtonpost.com/2012/09/19/marijuana-and-cancer_n_1898208.html?utm_hp_ref=fb&src=sp&comm_ref=false
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Post by beebs on Oct 21, 2012 11:05:04 GMT -5
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Post by beebs on Feb 23, 2013 16:37:39 GMT -5
Get a grip, do your home work. The US health officials have known and suppressed data about cannabis high antioxidants, anti inflammatory, and nutritious compounds, as well as shrinking tumors and curing cancer, for over 60 years. Read below: ( 1 of 1 ) United States Patent 6,630,507 Hampson , et al. October 7, 2003 **Please see images for: ( Certificate of Correction ) ** Cannabinoids as antioxidants and neuroprotectants Abstract Cannabinoids have been found to have antioxidant properties, unrelated to NMDA receptor antagonism. This new found property makes cannabinoids useful in the treatment and prophylaxis of wide variety of oxidation associated diseases, such as ischemic, age-related, inflammatory and autoimmune diseases. The cannabinoids are found to have particular application as neuroprotectants, for example in limiting neurological damage following ischemic insults, such as stroke and trauma, or in the treatment of neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease and HIV dementia. Nonpsychoactive cannabinoids, such as cannabidoil, are particularly advantageous to use because they avoid toxicity that is encountered with psychoactive cannabinoids at high doses useful in the method of the present invention. A particular disclosed class of cannabinoids useful as neuroprotective antioxidants is formula (I) wherein the R group is independently selected from the group consisting of H, CH.sub.3, and COCH.sub.3. ##STR1## Inventors: Hampson; Aidan J. (Irvine, CA), Axelrod; Julius (Rockville, MD), Grimaldi; Maurizio (Bethesda, MD) Assignee: The United States of America as represented by the Department of Health and Human Services (Washington, DC) Family ID: 26767641 Appl. No.: 09/674,028 Filed: February 2, 2001 PCT Filed: April 21, 1999 PCT No.: PCT/US99/08769 PCT Pub. No.: WO99/53917 PCT Pub. Date: October 28, 1999 Current U.S. Class: 514/454 Current International Class: A61K 31/35 (20060101); A61K 031/35 () Current CPC Class: A61K 31/35 (20130101) Field of Search: 514/454 References Cited [Referenced By] Cont/.. patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=/netahtml/PTO/srchnum.htm&r=1&f=G&l=50&s1=6630507.PN.&OS=PN/6630507&RS=PN/6630507
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Post by beebs on Apr 1, 2013 10:40:15 GMT -5
I know personally of a few using high CBD high oil content successfully for ischemic heart disease, based on scientific research, safer option to toxic meds. www.ncbi.nlm.nih.gov/pubmed/17890433Am J Physiol Heart Circ Physiol. 2007 Dec;293(6):H3602-7. Epub 2007 Sep 21. Cannabidiol, a nonpsychoactive Cannabis constituent, protects against myocardial ischemic reperfusion injury. Durst R, Danenberg H, Gallily R, Mechoulam R, Meir K, Grad E, Beeri R, Pugatsch T, Tarsish E, Lotan C. Source Cardiology Department, Hadassah Hebrew University Medical Center, Jerusalem, Israel. rdurst@partners.org Abstract Cannabidiol (CBD) is a major, nonpsychoactive Cannabis constituent with anti-inflammatory activity mediated by enhancing adenosine signaling. Inasmuch as adenosine receptors are promising pharmaceutical targets for ischemic heart diseases, we tested the effect of CBD on ischemic rat hearts. For the in vivo studies, the left anterior descending coronary artery was transiently ligated for 30 min, and the rats were treated for 7 days with CBD (5 mg/kg ip) or vehicle. Cardiac function was studied by echocardiography. Infarcts were examined morphometrically and histologically. For ex vivo evaluation, CBD was administered 24 and 1 h before the animals were killed, and hearts were harvested for physiological measurements. In vivo studies showed preservation of shortening fraction in CBD-treated animals: from 48 +/- 8 to 39 +/- 8% and from 44 +/- 5 to 32 +/- 9% in CBD-treated and control rats, respectively (n = 14, P < 0.05). Infarct size was reduced by 66% in CBD-treated animals, despite nearly identical areas at risk (9.6 +/- 3.9 and 28.2 +/- 7.0% in CBD and controls, respectively, P < 0.001) and granulation tissue proportion as assessed qualitatively. Infarcts in CBD-treated animals were associated with reduced myocardial inflammation and reduced IL-6 levels (254 +/- 22 and 2,812 +/- 500 pg/ml in CBD and control rats, respectively, P < 0.01). In isolated hearts, no significant difference in infarct size, left ventricular developed pressures during ischemia and reperfusion, or coronary flow could be detected between CBD-treated and control hearts. Our study shows that CBD induces a substantial in vivo cardioprotective effect from ischemia that is not observed ex vivo. Inasmuch as CBD has previously been administered to humans without causing side effects, it may represent a promising novel treatment for myocardial ischemia.
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Post by Admin on Jun 11, 2014 16:39:42 GMT -5
Beware taking cannabis oil without doing your own research. High THC, can cause arrythmias, angina, and heart attacks. Check for source, purity, lab tested, mold, and other impurities, seeds variety, if transgenic and so forth. Medical cannabis forum members report angina, and heart attacks from smoking and cannabis oil. Contradictory studies show the opposite. Welcome to the world of science. If I was to take cannabis oil, I would choose Harlequin or Catatonia, both contain low level of THC and higher level of CBD, or juice fresh leaves which does not contain THC, but non psychoactive THC A Int J Cardiol. 2007 May 31;118(2):141-4. Epub 2006 Sep 26. Marijuana as a trigger of cardiovascular events: speculation or scientific certainty? Aryana A1, Williams MA. Author information Abstract Marijuana is the most widely used illicit substance in the United States. Cardiovascular complications in association with marijuana use have been reported during the past three decades. In view of the elevated public interest in this drug's role in pharmacotherapy in the recent years and the aging population of long-term marijuana users from the late 1960s, encounters with marijuana-related cardiovascular adversities may be silently on the rise. The purpose of this article is to increase awareness of the potential of marijuana to lead to cardiovascular disease. Here, we will discuss the physiologic effects of marijuana and include a comprehensive review of the studies and case reports that provide supportive evidence for marijuana as a trigger of adverse cardiovascular events, including tachyarrhythmias, acute coronary syndrome, vascular complications, and even congenital heart defects. J Postgrad Med. 2006 Jan-Mar;52(1):51-6. Drug-induced myocardial infarction secondary to coronary artery spasm in teenagers and young adults. El Menyar AA. Author information linkAbstract There is no published registry for drug-induced acute myocardial infarction (AMI) with subsequent patent coronary angiogram in teenagers. To highlight the mechanism and impact of drug-induced MI with patent coronary arteries among teenagers who have relatively few coronary risk factors in comparison with older patients, we conducted a review of the literature. In this review most of the pertinent published (English and non-English) articles through the Medline, Scopus, Cochrane Database of Systematic Reviews and EBSCO Host research databases from 1970 to 2005 have been revised. Teenagers and young adults with AMI and subsequent patent coronary angiogram were included. In those cases drug-induced coronary spasm was highlighted. Among 220 articles (>12000 cases) related with AMI with normal coronary angiogram, 50 articles (approximately 100 cases) reported the role of drug in AMI secondary to coronary artery spasm (CAS). There is no well-conducted trial for AMI secondary to CAS in young adults but only a series of case reports and the diagnosis in most of cases was based on the clinical and laboratory findings without provocation. CAS was associated with 12 illicit substances in teenagers (i.e, cocaine, marijuana, alcohol, butane and amphetamine). Smoking is not only the initiative but also might harbor other illicit substances that increase the risk for CAS. Cocaine-associated AMI is the most frequent in various research papers. CAS was reported with 19 types of medications (i.e, over-the-counter, chemotherapy, antimigraine and antibiotics) without strong relation to age. Despite drug-induced AMI being not a common event, attention to smoking and drugs in teenagers and young adults will have major therapeutic and prognostic implications. More articles: link
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Post by Bathroomsdum on Mar 17, 2019 3:22:50 GMT -5
Hey! Gray bathroom remodel Staten Island : <a href=https://bathroom-remodel.club>Bathroom remodel gray and white</a>
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