|
Post by Admin on May 18, 2012 15:49:30 GMT -5
Two posts copied and pasted from the Phyto thread: Polyphenols and neuroprotection against ischemia and neurodegeneration.Lin B. Source Department of Neurology, University of Miami, Miller School of Medicine, Miami, Florida, USA. blin@med.miami.edu Abstract Neuroprotection of polyphenols in medical plants is getting attention in the world. Scutellaria baicalensis, paeonia veitchii and paeonia suffruticosa have been extensively studied in the last 10 years and show multi-function. They are neuroprotectants, antioxidants, anti-inflammatory and antithrombic agents as well as vasoconstriction inhibitors and amyloid-peptide (Aβ) cleaners by means of their polyphenols: baicalin, baicalein, wogonin (in scutellaria), and paeonol, paeonoside, paeoniflorin (PF) and 1, 2, 3, 4, 6-Penta-O-galloyl-beta-D-glucose (PGG) (in paeonia veitchii and paeonia suffruticosa). Other 4 medical plants: astragali, ligusticum wallichii, angelica sinensis and carthamus tinctorius (saffron) have been the major medicines to treat ischemia for hundreds of years in China, Korea and Japan. Our recent experimental studies demonstrated the neuroprotective efficacy of the combination of these phyotmedicines on mitigating brain infarction and global ischemia as well as preventing the neurodegeneration following ischemia. Owing to their multi-function, including improving cerebral blood circulation, they therefore have the potential to alleviate the symptoms of degenerative diseases, Alzheimer's disease (AD) and Parkinson's disease (PD). Pharmacology of the 7 herbs and their major relative polyphenols is depicted in the article. www.ncbi.nlm.nih.gov/pubmed/22070681
|
|
|
Post by Admin on May 18, 2012 15:50:32 GMT -5
This study shows that oxygen deprived cells and glucose starved cells swell by >34 % and that cells, and mitochondrial membrane of the glial cells (look it up, not difficult to understand), worsened. This could lead to head pressures, cognitive dysfunction, intracranial head pressures etc... In contrast, cells that were exposed to cinnamon extract had no swelling!! Glutamate uptake was lessened. The study does not discuss a connection with drug injury, nor do other studies, but Ayurvedic lit does include drug injury as a trigger!! As a side note, the study does not mention Ayurvedic medicine, it was conducted in the USA by the Dept of Agriculture. A procyanidin type A trimer from cinnamon extract attenuates glial cell swelling and the reduction in glutamate uptake following ischemia-like injury in vitro.Panickar KS, Polansky MM, Graves DJ, Urban JF Jr, Anderson RA. Source United States Department of Agriculture, Agricultural Research Service, Beltsville Human Nutrition Research Center, Diet, Genomics and Immunology Laboratory, Beltsville, MD 20705, USA. kiran.panickar@ars.usda.gov Abstract Dietary polyphenols exert neuroprotective effects in ischemic injury. The protective effects of a procyanidin type A trimer (trimer 1) isolated from a water soluble cinnamon extract (CE) were investigated on key features of ischemic injury, including cell swelling, increased free radical production, increased intracellular calcium ([Ca(2+)](i)), mitochondrial dysfunction, and the reduction in glutamate uptake. Astrocyte (glial) swelling is a major component of cytotoxic brain edema in ischemia and, along with vasogenic edema, may contribute to increased intracranial pressure, brain herniation, and additional ischemic injuries. C6 glial cultures were exposed to oxygen-glucose deprivation (OGD) for 5 h, and cell swelling was determined at 90 min after the end of OGD. OGD-induced increases in glial swelling were significantly blocked by trimer 1, but not by the major nonpolyphenol fractions of CE including cinnamaldehyde and coumarin. Increased free radical production, a contributing factor in cell swelling following ischemic injury, was also significantly reduced by trimer 1. Mitochondrial dysfunction, another key feature of ischemic injury, is hypothesized to contribute to glial swelling. Depolarization of the inner mitochondrial membrane potential (ΔΨ(m)) was assessed using a fluorescent dye (tetramethylrhodamine ethyl ester [TMRE]), and was significantly attenuated by trimer 1 as was OGD-induced increased [Ca(2+)](i). Taken together with our previous observation that blockers of [Ca(2+)](i) reduce cell swelling, our results indicate that trimer 1 may attenuate cell swelling by regulating [Ca(2+)](i). Trimer 1 also significantly attenuated the OGD-induced decrease in glutamate uptake. In addition, cyclosporin A, a blocker of the mitochondrial permeability pore (mPT), but not FK506 (that does not block the mPT), reduced the OGD-induced decline in glutamate uptake indicating a role of the mPT in such effects. Thus, the effects of trimer 1 in attenuating the reduction in glutamate uptake are likely mediated through their action on the mitochondria. www.ncbi.nlm.nih.gov/pubmed/22166344
|
|
|
Post by beebs on May 18, 2012 16:22:32 GMT -5
Polyphenols and neuroprotection against ischemia and neurodegeneration.Lin B. Source Department of Neurology, University of Miami, Miller School of Medicine, Miami, Florida, USA. blin@med.miami.edu Abstract Neuroprotection of polyphenols in medical plants is getting attention in the world. Scutellaria baicalensis, paeonia veitchii and paeonia suffruticosa have been extensively studied in the last 10 years and show multi-function. They are neuroprotectants, antioxidants, anti-inflammatory and antithrombic agents as well as vasoconstriction inhibitors and amyloid-peptide (Aβ) cleaners by means of their polyphenols: baicalin, baicalein, wogonin (in scutellaria), and paeonol, paeonoside, paeoniflorin (PF) and 1, 2, 3, 4, 6-Penta-O-galloyl-beta-D-glucose (PGG) (in paeonia veitchii and paeonia suffruticosa). Other 4 medical plants: astragali, ligusticum wallichii, angelica sinensis and carthamus tinctorius (saffron) have been the major medicines to treat ischemia for hundreds of years in China, Korea and Japan. Our recent experimental studies demonstrated the neuroprotective efficacy of the combination of these phyotmedicines on mitigating brain infarction and global ischemia as well as preventing the neurodegeneration following ischemia. Owing to their multi-function, including improving cerebral blood circulation, they therefore have the potential to alleviate the symptoms of degenerative diseases, Alzheimer's disease (AD) and Parkinson's disease (PD). Pharmacology of the 7 herbs and their major relative polyphenols is depicted in the article. www.ncbi.nlm.nih.gov/pubmed/22070681
|
|
|
Post by beebs on Jun 19, 2012 10:02:47 GMT -5
Anise Oil shows evidence of being neuroprotective, helpful for epilepsy, anti neuronal hypxia!! Anticonvulsant and neuroprotective effects of Pimpinella anisum in rat brainFariba Karimzadeh, Mahmoud Hosseini, Diana Mangeng, Hassan Alavi, Gholam Reza Hassanzadeh, Mohamad Bayat, Maryam Jafaryan, Hadi Kazemi and Ali Gorji Abstract (provisional) Background Essential oil of Pimpinella anisum L. Apiaceae (anise oil) has been widely used in traditional Persian medicine to treat a variety of diseases, including some neurological disorders. This study was aimed to test the possible anti-seizure and anti-hypoxia effects of anise oil. Methods The effects of different concentrations of anise oil were tested on seizure attacks induced by pentylenetetrazol (PTZ) injection and neuronal hypoxia induced by oxygen withdrawal as well as on production of dark neurons and induction of long-term potentiation (LTP) in in vivo and in vitro experimental models of rat brain. Results Anise oil significantly prolonged the latency of seizure attacks and reduced the amplitude and duration of epileptiform burst discharges induced by injection of intraperitoneal PTZ. In addition, anise oil significantly inhibited production of dark neurons in different regions of the brain in epileptic rats. Anise oil also significantly enhanced the duration of the appearance of anoxic terminal negativity induced by oxygen withdrawal and inhibited induction of LTP in hippocampal slices. Conclusion Our data indicate the anticonvulsant and neuroprotective effects of anise oil, likely via inhibition of synaptic plasticity. Further evaluation of anise oil to use in the treatment of neurological disorders is suggested. www.biomedcentral.com/1472-6882/12/76/abstract
|
|
|
Post by beebs on Jun 24, 2012 11:04:51 GMT -5
Neuro research posted on this forum, encompasses, CFS, neuro-endocrine, Alzheimers, Parkinson etc. Its all connected Read and understand what is happening in terms of neuro symptoms/diseases. You will find similarities in biological processes and overlapping commonalities in all of them, including diabetes, or excesses of insulin, glucose etc.. I met five people, not on the Internet,who reversed epilepsy, MS x 2, other two, cancer. What did they do? Change of diet + vits and supps. High fat, lard, coconut oil, omega 3,6,9 no carbs etc.. vits and supps. Strongly recommend you do further research on Dr Patricia Kane ( I disagree with some, and the methodology) and Dr Wahls, vid below, and other protocols. Analyze, ask questions, be critical, motivated. deductive thinking. No doctors will help here, there is no magic bullet, its up to YOUR hard work. You can reverse the damage. Be prepared for trial and error, tweak here and there, and above all, listen to WHAT YOUR BODY TELLS YOU.. tweak, experiment, adjust to suit you. So much sicentists/doctors don't know and understand. Start slowly, gently, gradually. BE PATIENT, real healing here takes time... I wrote on another thread, that I am having bone broth daily, and reiterate, how helpful this has been. I am unable to follow most protocols, because of allergies and inability to metabolize many compounds in foods. However, this is improved, having been on oxtail home made broths daily. I can't have fish and other broths because of allergies, those are helpful too. Over the years, I learned that spending a fortune on seeing "experts" neurologists/neuroscientists, avoided painful, toxic costly procedures, were as helpful. Tried a methylation protocol which was helpful to an extent, crashed when I stopped. I am focused on the nutritional approach, do not take any medications, few vits and supps and trace minerals. Dr Wahls diet is helping many recover, not just MS patients. Worth a try, nothing to loose. [youtube] www.youtube.com/watch?v=Fs7jqqdv5eg&feature=related[/youtube]www.amazon.com/Minding-Mitochondria-2nd-progressive-wheelchair/dp/0982175086/ref=sr_1_1?ie=UTF8&qid=1324423700&sr=8-1www.terrywahls.org/terrywahls.blogspot.com/2009/05/diet-ms-and-neurodegeneration.htmlTwo of six vids: h
|
|
|
Post by beebs on Nov 19, 2012 16:14:18 GMT -5
Worth reading publications on all neurodegenerative diseases. There are commonalities between many neurological symptoms from FQs, Lariam etc... See paper below and do your own research before taking supps. Combination Therapy with Coenzyme Q10 and Creatine Produces Additive Neuroprotective Effects in Models of Parkinson’s and Huntington’s DiseasesLichuan Yang,1 Noel Y. Calingasan,1 Elizabeth J. Wille,1 Kerry Cormier,2,3 Karen Smith,2,3 Robert J. Ferrante,2,3 and M. Flint Beal1 Author information ► Copyright and License information ► The publisher's final edited version of this article is available at J Neurochem See other articles in PMC that cite the published article. Go to: Abstract Coenzyme Q10 (CoQ10) and creatine are promising agents for neuroprotection in neurodegenerative diseases via their effects on improving mitochondrial function and cellular bioenergetics and their properties as antioxidants. We examined whether a combination of CoQ10 with creatine can exert additive neuroprotective effects in a MPTP mouse model of Parkinson’s disease (PD), a 3-NP rat model of Huntington’s disease (HD) and the R6/2 transgenic mouse model of HD. The combination of the two agents produced additive neuroprotective effects against dopamine depletion in the striatum and loss of tyrosine hydroxylase neurons in the substantia nigra pars compacta (SNpc) following chronic subcutaneous administration of MPTP. The combination treatment resulted in significant reduction in lipid peroxidation and pathologic α-synuclein accumulation in the SNpc neurons of the MPTP-treated mice. We also observed additive neuroprotective effects in reducing striatal lesion volumes produced by chronic subcutaneous administration of 3-NP to rats. The combination treatment showed significant effects on blocking 3-NP-induced impairment of glutathione homeostasis and reducing lipid peroxidation and DNA oxidative damage in the striatum. Lastly, the combination of CoQ10 and creatine produced additive neuroprotective effects on improving motor performance and extending survival in the transgenic R6/2 HD mice. These findings suggest that combination therapy using CoQ10 and creatine may be useful in the treatment of neurodegenerative diseases such as PD and HD. Full article accessible: www.ncbi.nlm.nih.gov/pmc/articles/PMC2866530/
|
|