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Post by beebs on Feb 23, 2012 16:59:28 GMT -5
The onus lies with us to read up on compounds in various foods and its epigenetic effects. For instance, looking at ethnic foods and reading up on why and how local population use certain foods for certain ailments, whilst we wait for Western science to validate, those practices have stood the test of time. Nutrition Can Modulate the Toxicity of Environmental Pollutants: Implications in Risk Assessment and Human Health ehp03.niehs.nih.gov/article/info:doi/10.1289/ehp.1104712Bernhard Hennig, Lindell Ormsbee, Craig J. McClain, Bruce A. Watkins, Bruce Blumberg, Leonidas G. Bachas, Wayne Sanderson, Claudia Thompson, William A. Suk Abstract Top Background: The paradigm of human risk assessment includes many variables that must be viewed collectively in order to improve human health and prevent chronic disease. The pathology of chronic diseases is complex, though, and may be influenced by exposure to environmental pollutants, a sedentary lifestyle and poor dietary habits. Much emerging evidence suggests that nutrition can modulate the toxicity of environmental pollutants, which may alter human risks associated with toxicant exposures.Objectives: This commentary discusses the basis for recommending that nutrition be considered as a critical variable in disease outcomes associated with exposure to environmental pollutants, thus establishing the importance of incorporating nutrition within the context of cumulative risk assessment. Discussion: There is a convincing body of research indicating that nutrition is a modulator of vulnerability to environmental insults; thus, it is timely to consider nutrition as a vital component of human risk assessment. Nutrition may serve as either an agonist or antagonist (e.g. high fat foods or foods rich in antioxidants, respectively) of the health impacts associated with exposure to environmental pollutants. Dietary practices and food choices may help explain the large variability observed in human risk assessment. Conclusion: We recommend that nutrition and dietary practices be incorporated into future environmental research and the development of risk assessment paradigms. Healthful nutrition interventions might be a powerful approach to reduce disease risks associated with many environmental toxic insults, and should be considered a variable within the context of cumulative risk assessment, and where appropriate, a potential tool for subsequent risk reduction. Citation: Hennig B, Ormsbee L, McClain CJ, Watkins BA, Blumberg B, Bachas LG, et al. 2012. Nutrition Can Modulate the Toxicity of Environmental Pollutants: Implications in Risk Assessment and Human Health. Environ Health Perspect :-. dx.doi.org/10.1289/ehp.1104712
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Post by beebs on Sept 11, 2012 15:18:04 GMT -5
A while ago, I read about a man who had epileptic episodes. He consulted a nutritionist and was told to keep a food diary. A few weeks later, it was found that carrots were the culprits. Likewise, a UK based GP found that by giving up all fruits and veggies, her fibromylagia resolved. Many factors could be involved, including transgenic foods causing unknown mutations, vaccines, pesticides, insecticides and other environmental factors, as well as ADRs causing damage to the digestive system. It seems to be a recurring theme with gut issues.. Dietary 'excitotoxins' linked with fibromyalgia and irritable bowel syndrome www.drbriffa.com/2012/08/31/dietary-excitotoxins-linked-with-fibromyalgia-and-irritable-bowel-syndrome/ "A lot of conventional medicine is about symptom suppression. For example, with someone with ‘cramping’ in the gut we may give a drug to reduce the cramping. A better (I think) though more alternative approach would be to attempt to find out what’s causing the cramping and sort that out. As an aside, cramping in the gut and ‘irritable bowel syndrome’ is very often caused by food sensitivity in my experience, and wheat and perhaps other grains are common culprits."
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Post by beebs on Sept 13, 2012 7:30:31 GMT -5
Home Made Sauerkraut. The 2nd vid - traditional way using feet. you could potentially use urine as fertiliser, ;D Part 2 of 3
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Post by beebs on Nov 8, 2012 15:28:55 GMT -5
Easy read about the application of using phytocems from foods to alter gene expression and ensuing biochemical reaction at cellular level. Understand that if you do suffer conditions from excitory TPRs, avoidance of capsaicin and allicin, as mentioned in the article are to be avoided!! Dietary factors, hormesis and health
Mark P. MattsonCorresponding author contact informationAbstract The impact of dietary factors on health and longevity is increasingly appreciated. The most prominent dietary factor that affects the risk of many different chronic diseases is energy intake – excessive calorie intake increases the risk. Reducing energy intake by controlled caloric restriction or intermittent fasting increases lifespan and protects various tissues against disease, in part, by hormesis mechanisms that increase cellular stress resistance. Some specific dietary components may also exert health benefits by inducing adaptive cellular stress responses. Indeed, recent findings suggest that several heavily studied phytochemicals exhibit biphasic dose responses on cells with low doses activating signaling pathways that result in increased expression of genes encoding cytoprotective proteins including antioxidant enzymes, protein chaperones, growth factors and mitochondrial proteins. Examples include: activation of the Nrf-2—ARE pathway by sulforaphane and curcumin; activation of TRP ion channels by allicin and capsaicin; and activation of sirtuin-1 by resveratrol. Research that establishes dose response and kinetic characteristics of the effects of dietary factors on cells, animals and humans will lead to a better understanding of hormesis and to improvements in dietary interventions for disease prevention and treatment. www.sciencedirect.com/science/article/pii/S1568163707000451
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Post by beebs on Dec 11, 2012 15:02:28 GMT -5
Regardless of modality to address redox and homeostasis, by means of facilitating DNA repair enzyme, its crucial to healing. The article focuses on Acetyl-L-Carnitine. Look up food source, mainly meat and dairy. Helpful for neurological symptoms. As a side note, several articles show India with the highest percentage of heart diseases, including heart failure, resulting from vegetarianism. L-Carnitine in its various forms are extremely important for the heart, brain function and musculoskeletal. Serum, urine or tissue sampling are unreliable. Acetylcarnitine and cellular stress response: roles in nutritional redox homeostasis and regulation of longevity genes
Vittorio Calabresea, Corresponding author contact information, Anna Maria Giuffrida Stellaa, Menotti Calvanib, D. Allan Butterfieldc Department of Chemistry, Biochemistry and Molecular Biology Section, Faculty of Medicine, University of Catania, 95100 Catania, Italy b Department of Physiology, University of Rome Tor Vergata, 00133 Rome, Italy c Department of Chemistry, Center for Membrane Science, and Sanders-Brown Center on Aging, University of Kentucky, Lexington, KY 40506, USA Abstract Aging is associated with a reduced ability to cope with physiological challenges. Although the mechanisms underlying age-related alterations in stress tolerance are not well defined, many studies support the validity of the oxidative stress hypothesis, which suggests that lowered functional capacity in aged organisms is the result of an increased generation of reactive oxygen and nitrogen species. Increased production of oxidants in vivo can cause damage to intracellular macromolecules, which can translate into oxidative injury, impaired function and cell death in vulnerable tissues such as the brain. To survive different types of injuries, brain cells have evolved networks of responses, which detect and control diverse forms of stress. This is accomplished by a complex network of the so-called longevity assurance processes, which are composed of several genes termed vitagenes. Among these, heat shock proteins form a highly conserved system responsible for the preservation and repair of the correct protein conformation. The heat shock response contributes to establishing a cytoprotective state in a wide variety of human diseases, including inflammation, cancer, aging and neurodegenerative disorders. Given the broad cytoprotective properties of the heat shock response, there is now a strong interest in discovering and developing pharmacological agents capable of inducing the heat shock response. Acetylcarnitine is proposed as a therapeutic agent for several neurodegenerative disorders, and there is now evidence that it may play a critical role as modulator of cellular stress response in health and disease states. In the present review, we first discuss the role of nutrition in carnitine metabolism, followed by a discussion of carnitine and acetyl-l-carnitine in mitochondrial dysfunction, in aging, and in age-related disorders. We then review the evidence for the role of acetylcarnitine in modulating redox-dependent mechanisms leading to up-regulation of vitagenes in brain, and we also discuss new approaches for investigating the mechanisms of lifetime survival and longevity. Keywords Acetylcarnitine; Cellular stress response; Redox homeostasis; Vitagenes; Heme oxygenase; Heat shock response www.sciencedirect.com/science/article/pii/S0955286305002433
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Post by beebs on Dec 25, 2012 10:39:52 GMT -5
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