Post by beebs on Oct 27, 2011 10:50:50 GMT -5
Mmm, does not that sound like homeopathy??? ;D ha ha, let me guess, they will rename homeopathy as HDTT??? with the stamp of approval from the FDA??
Developments on drug discovery and on new therapeutics: highly diluted tinctures act as biological response modifiers
Carolina C de Oliveira email, Ana Paula R Abud email, Simone M de Oliveira email, Fernando DE SF Guimaraes email, Lucas F de Andrade email, Raffaello P di Bernardi email, Ediely L DE O Coletto email, Diogo Kuczera email, Eneida J da Lozzo email, Jenifer P Goncalves email, Edvaldo DA S Trindade email and Dorly DE F Buchi email
BMC Complementary and Alternative Medicine 2011, 11:101doi:10.1186/1472-6882-11-101
Published: 26 October 2011
Abstract (provisional)
Background
In the search for new therapies novel drugs and medications are being discovered, developed and tested in laboratories. Highly diluted substances are intended to enhance immune system responses resulting in reduced frequency of various diseases, and often present no risk of serious side-effects due to its low toxicity. Over the past years our research group has been investigating the action of highly diluted substances and tinctures on cells from the immune system.
Methods
We have developed and tested several highly diluted tinctures and here we describe the biological activity of M1, M2, and M8 both in vitro in immune cells from mice and human, and in vivo in mice. Cytotoxicity, cytokines released and NF-kappaB activation were determined after in vitro treatment. Cell viability, oxidative response, lipid peroxidation, bone marrow and lymph node cells immunophenotyping were accessed after mice in vivo treatment.
Results
None of the highly diluted tinctures tested were cytotoxic to macrophages or K562. Lipopolysaccharide (LPS)-stimulated macrophages treated with all highly diluted tinctures decreased tumour necrosis factor alpha (TNF-alpha) release and M1, and M8 decreased IFN-gamma production. M1 has decreased NF-kappaB activity on TNF-alpha stimulated reporter cell line. In vivo treatment lead to a decrease in reactive oxygen species (ROS), nitric oxide (NO) production was increased by M1, and M8, and lipid peroxidation was induced by M1, and M2. All compounds enhanced the innate immunity, but M1 also augmented acquired immunity and M2 diminished B lymphocytes, responsible to acquired immunity.
Conclusions
Based on the results presented here, these highly diluted tinctures were shown to modulate immune responses. Even though further investigation is needed there is an indication that these highly diluted tinctures could be used as therapeutic interventions in disorders where the immune system is compromised.
www.biomedcentral.com/1472-6882/11/101/abstract