|
Post by beebs on May 14, 2011 14:52:58 GMT -5
Cancer is not a disease. Cancer cells changes occur several times throughout a life time, some reverting to normal, others proliferate. Dr Simoncinni's protocol of bicarbonate of soda, show a high recovery rate A search for his pdf document where it explains in details its uses, cancer cell is a fungi, you will find that a lot of what he says makes sense, or not. Cancer triggers are numerous, nutritional deficiencies, excesses, toxins, viruses, bacteria, medications, air pollution, etc.. contributory factors. www.cancerfungus.com/and www.curenaturalicancro.com/en/PubMed article: Sodium Bicarbonate, Ph and metastases Bicarbonate Increases Tumor pH and Inhibits Spontaneous MetastasesPublished Online First on March 10, 2009 Research by: Arizona Cancer Center, University of Arizona, Tucson, Arizona Department of Pharmacology, Wayne State University, Detroit, Michigan H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida Ian F. Robey, Brenda K. Baggett, Nathaniel D. Kirkpatrick, Denise J. Roe, Julie Dosescu, Bonnie F. Sloane, Arig Ibrahim Hashim, David L. Morse, Natarajan Raghunand, Robert A. Gatenby, and Robert J. Gillies Abstract The external pH of solid tumors is acidic as a consequence of increased metabolism of glucose and poor perfusion. Acid pH has been shown to stimulate tumor cell invasion and metastasis in vitro and in cells before tail vein injection in vivo. The present study investigates whether inhibition of this tumor acidity will reduce the incidence of in vivo metastases. They show that oral NaHCO3 selectively increased the pH of tumors and reduced the formation of spontaneous metastases in mouse models of metastatic breast cancer. This treatment regimen was shown to significantly increase the extracellular pH, but not the intracellular pH, of tumors by 31P magnetic resonance spectroscopy and the export of acid from growing tumors by fluorescence microscopy of tumors grown in window chambers. NaHCO3 therapy also reduced the rate of lymph node involvement, yet did not affect the levels of circulating tumor cells, suggesting that reduced organ metastases were not due to increased intravasation. In contrast, NaHCO3 therapy significantly reduced the formation of hepatic metastases following intrasplenic injection, suggesting that it did inhibit extravasation and colonization. In tail vein injections of alternative cancer models, bicarbonate had mixed results, inhibiting the formation of metastases from PC3M prostate cancer cells, but not those of B16 melanoma. Although the mechanism of this therapy is not known with certainty, low pH was shown to increase the release of active cathepsin B, an important matrix remodeling protease. Source: Cancer Res 2009;69(6):2260–8 | PMID: 19276390 Two YT vids about Dr Simoncinni's theory: There are five vids, the next one is about a Dutch patient who went to Italy seeking a cure from her breast cancer from Dr Simoncinni. www.youtube.com/watch?v=_ID3_3h6ra0&feature=mfu_in_order&list=ULRead more: health-quest.proboards.com/index.cgi?action=display&board=diseasesresearch&thread=78&page=1#ixzz1MMG2Qfim
|
|
|
Post by beebs on May 14, 2011 15:17:51 GMT -5
The post about soursop vanished, am reposting the info. img803.imageshack.us/img803/2562/thumbnail.jpgYou can read abou the politics behind the scene, and one pharmaceutical company's attempt at patent the extract from leaves, bark and fruit, was unsuccessful. searchdominica.com/natural-remedies/soursop-graviola-guanabana and www.amedicalcare.com/search/drying%20graviola%20leavesRead the contraindications in the link provided at the end of copy and paste extract from the article below....Cont/ Biological Activites and Clinical ResearchIn an 1976 plant screening program by the National Cancer Institute, graviola leaves and stem showed active toxicity against cancer cells and researchers have been following up on these findings since. Thus far, specific acetogenins in graviola and/or extracts of graviola have been reported to be selectively toxic in vitro to these types of tumor cells: lung carcinoma cell lines; human breast solid tumor lines; prostate adenocarcinoma; pancreatic carcinoma cell lines; colon adenocarcinoma cell lines; liver cancer cell lines; human lymphoma cell lines; and multi-drug resistant human breast adenocarcinoma. Researchers in Taiwan reported in 2003 that the main graviola acetogenin, annonacin, was highly toxic to ovarian, cervical, breast, bladder and skin cancer cell lines at very low dosages saying; "... annonacin is a promising anti-cancer agent and worthy of further animal studies and, we would hope, clinical trials." An interesting in vivo study was published in March of 2002 by researchers in Japan, who were studying various acetogenins found in several species of plants. They inoculated mice with lung cancer cells. One third received nothing (the control group), one third received the chemotherapy drug adriamycin, and one third received the main graviola acetogenin, annonacin (at a dosage of 10 mg/kg). At the end of two weeks, five of the six in the untreated control group were still alive and lung tumor sizes were then measured. The adriamycin group showed a 54.6% reduction of tumor mass over the control group - but 50% of the animals had died from toxicity (three of six). The mice receiving annonacin were all still alive, and the tumors were inhibited by 57.9% "slightly better than adriamycin" and without toxicity. This led the researchers to summarize; "This suggested that annonacin was less toxic in mice. On considering the anti-tumor activity and toxicity, annonacin might be used as a lead to develop a potential anticancer agent." Cancer research is ongoing on these important Annona plants and plant chemicals, as several pharmaceutical companies and universities continue to research, test, patent, and attempt to synthesize these chemicals into new chemotherapeutic drugs. In fact, graviola seems to be following the same path as another well known cancer drug - Taxol. From the time researchers first discovered an antitumorous effect in the bark of the pacific yew tree and a novel chemical called taxol was discovered in its bark - it took thirty years of research by numerous pharmaceutical companies, universities, and government agencies before the first FDA-approved Taxol drug was sold to a cancer patient (which was based on the natural taxol chemical they found in the tree bark). With graviola, it has taken researchers almost 10 years to successfully synthesize (chemically reproduce) the main antitumorous chemical, annonacin. These acetogenin chemicals have a unique waxy center and other unique molecular energy properties which thwarted earlier attempts, and at least one major pharmaceutical company gave up in the process (despite knowing how active the natural chemical was against tumors). Now that scientists have the ability to recreate this chemical and several other active acetogenins in the laboratory, the next step is to change the chemical just enough (without losing any of the antitumorous actions in the process) to become a novel chemical which can be patented and turned into a new patented cancer drug. (Naturally-occurring plant chemicals cannot be patented.) Thus far, scientists seem to be thwarted ag-ain every time they change the chemical enough to be patentable, they lose much of the antitumorous actions. Like the development of taxol, it may well take government agenies like the National Cancer Institute and the National Institute of Health to step forward and launch full-scale human cancer research on the synthesized unpatentable natural plant chemical (which will allow any pharmaceutical company to develop a cancer drug utilizing the research as happened with taxol) to be able to make this promising therapy available to cancer patients in a timely fashion. In the meantime, many cancer patients and health practitioners are not waiting - they are adding the natural leaf and stem of graviola (with over 40 documented naturally-occurring acetogenins including annonacin) as a complementary therapy to their cancer protocols. After all, graviola has a long history of safe use as a herbal remedy for other conditions for many years, and research indicates that the antitumorous acetogenins are selectively toxic to just cancer cells and not healthy cells - and in miniscule amounts. While research confirms that these antitumorous acetogenins also occur in high amounts in the fruit seeds and roots of graviola, different alkaloid chemicals in the seeds and roots have shown some preliminary in vitro neurotoxic effects. Researchers have suggested that these alkaloids might be linked to atypical Parkinson?s disease in countries where the seeds are employed as a common herbal parasite remedy. Therefore, using the seeds and root of graviola is not recommended at this time. The therapuetic dosage of graviola leaf, (which offers just as high of an amount of acetogenins as the root and almost as much as the seed) is reported to be 2-3 grams taken 3 or 4 times daily. Graviola products (capsules and tinctures) are becoming more widely available in the U.S. market, and now offered under several different manufacturer's labels in health food stores. As one of graviola's mechanisms of action is to deplete ATP energy to cancer cells, combining it with other supplements and natural products which increase or enhance cellular ATP may reduce the effect of graviola. The main supplement which increases ATP is a common antioxidant called Coenzyme Q10 and for this reason, it should be avoided when taking graviola. Graviola is certainly a promising natural remedy and one that again emphasizes the importance of preserving our remaining rainforest ecosystems. Perhaps - if enough people believe that the possible cure for cancer truly is locked away in a rainforest plant - we will take the steps needed to protect our remaining rainforests from destruction. One researcher studying graviola summarized this idea eloquently: "At the time of preparation of this current review, over 350 Annonaceous acetogenins have been isolated from 37 species. Our preliminary efforts show that about 50%, of over 80 Annonaceous species screened, are significantly bioactive and are worthy of fractionation; thus, this class of compounds can be expected to continue to grow at an exponential rate in the future, provided that financial support for such research efforts can be found. With the demise of the world's tropical rain forests, such work is compelling before the great chemical diversity, contained within these endangered species, is lost." www.life-enthusiast.com/index/Ingredients/Plants/Graviola
|
|
|
Post by beebs on May 15, 2011 6:38:05 GMT -5
Dr Burzunski, has been vilified and attacked by the establishment over the years. He was branded a quack. At one time, he was sentenced to 200 years in prison. WHY? Because he was curing cancer patients. Not good practice for Big Pharma ;D there is a doc somewhere on the site which explains in more details what he does. Dr B was on national news in the USA recently, hailed as a "hero", lol, yep, from quack to hero!! Dr Burzunksi theory and lifetime work focuses on antineoplaston, peptides we naturally produce in the body, other acids including amino acids. This site was started by his cured patients: www.burzynskipatientgroup.org/
|
|
|
Post by beebs on May 18, 2011 15:00:38 GMT -5
A Chinese herb that looks promising, Gynostemma pentaphyllum, (Chinese- jiaogulan), been used in Southern China as an adaptogen, that is to balance over all system. Powerful anti oxidants, anti inflammatory etc. Some are using to treat their cancers. I also read that it works differently on cancer cells, raises SODzyme, hence scavenging free radicals, and that it works on mitochondria as opposed to chemo. It is a powerful immune modulator, enhancing white blood cells proliferation and natural killer cells (NK-cells), lowers BP, lowers cholesterol etc. See on PubMed for 152 listed articles: www.ncbi.nlm.nih.gov/pubmed?term=Gynostemma%20pentaphyllum%20jiaogulanFor Information only Chemical Composition of Five Commercial Gynostemma pentaphyllum Samples and Their Radical Scavenging, Antiproliferative, and Anti-inflammatory Properties.Xie Z, Liu W, Huang H, Slavin M, Zhao Y, Whent M, Blackford J, Lutterodt H, Zhou H, Chen P, Wang TT, Wang S, Yu LL. Source Department of Nutrition and Food Science, University of Maryland, College Park, Maryland 20742, United States. Abstract Five Gynostemma pentaphyllum (GP) samples were investigated and compared for their chemical compositions and their antioxidant, antiproliferative, and anti-inflammatory effects. Extracts (50% acetone, 75% ethanol, and 100% ethanol) of the five GP samples (GP1-5) differed in their total phenolic, saponin, and flavonoid contents and in their rutin and quercetin concentrations. The highest level of total flavonoids was 63.5 mg of rutin equiv/g in GP4, and the greatest total phenolic content was 44.3 mg of gallic acid equiv/g in GP1 with 50% acetone as the extraction solvent. GP2 had the highest total saponin content of 132.6 mg/g with 100% ethanol as the extraction solvent. These extracts also differed in their scavenging capacity against DPPH and hydroxyl radicals, although they all showed significant radical scavenging capacity. The 100% ethanol extracts also showed dose-dependently strong inhibition on IL-6 and Ptgs2 mRNA expression and weak inhibition on TNF-α mRNA expression. In addition, GP1 had the highest antiproliferative activity at 3.2 mg equiv/mL concentration in HT-29 human colon cancer cells. The results from this study will be used to promote the application of G. pentaphyllum for improving human health. www.ncbi.nlm.nih.gov/pubmed/20939605
|
|
|
Post by Admin on May 23, 2011 19:26:07 GMT -5
Posted about Sage in an earlier post. The study below shows strong supportive evidence that Sage is preventive for colorectal cancers. More evidence from other published papers show the epigenetic influence of compounds in foods. Some can be beneficial, whilst others can be detrimental, specially if diet is not balanced and non nutritious. Modulation of DNA damage prevention and signaling pathways in diet induced colon cancer preventionDalila FN Pedro1 email, Alice A Ramos1, Cristóvão F Lima2, Fátima Baltazar3 and Cristina Pereira-Wilson1 1 CBMA, Department of Biology, University of Minho, Braga, Portugal 2 CITAB, Department of Biology, University of Minho, Braga, Portugal 3 ICVS - Life and Health Sciences Research Institute, University of Minho, Braga, Portugal Colorectal cancer (CRC) is a common malignancy and significant cause of mortality in Western societies. It develops through an accumulation of genetic and epigenetic alterations, transforming normal colon cells and giving them growth advantage. Epigenetic alterations are reversible and studies have shown that dietary compounds can alter the epigenetic status and reactivate epigenetically-silenced genes. Many food plants are rich in bioactive compounds and have shown to posses anticancer properties............SO decreased significantly the oxidative H2O2-induced DNA damage. We also are searching for alterations in expression of key proteins involved in signalling pathways important for cell proliferation or apoptosis and proteins involved in DNA repair. Sage water extract seems to have the ability to prevent CRC and studies to further explore this potential are ongoing. www.biomedcentral.com/1753-6561/4/S2/P58
|
|
|
Post by beebs on May 24, 2011 10:00:01 GMT -5
NAUSEAting.... Big Pharma and their paid henchmen (so called scientists) trash vits and supps. Concerning chemo and radiotherapy, its a no brainer, how could it work??? For a few months, may more, but then, since the cancer reseeds itself, will it no spring up elsewhere, even more so with damage from chemo and radio??? Aghhhhhhh There is a shift in medical/scientific journals to drip drip drip research about phytochemicals in plants and foods, as well as robbing Ayurvedic Medicine and Phytopherapy of their thousands of years knowledge about those compounds. This paper explores the antioxidative therapy both for preventing and treatment? (many have been cured already, so, how many more years do we have to wait for the endorsement of those henchemen/). In summary, the paper discuses the free radical scavenger from anti-oxidants. Mitochondrial Oxidative Stress Drives Tumor Progression and Metastasis: Should We Use Antioxidants As A Key Component of Cancer Treatment and Prevention?
Federica Sotgia email, Ubaldo E Martinez-Outschoorn email and Michael P Lisanti email BMC Medicine 2011, 9:62doi:10.1186/1741-7015-9-62 Published: 23 May 2011 Abstract (provisional) The functional role of oxidative stress in cancer pathogenesis has long been a hotly debated topic. A study published this month in BMC Cancer by Goh et al., directly addresses this issue by using a molecular genetic approach, via an established mouse animal model of human breast cancer. More specifically, alleviation of mitochondrial oxidative stress, via transgenic over-expression of catalase (an anti-oxidant enzyme) targeted to mitochondria, was sufficient to lower tumor grade (from high-to-low) and to dramatically reduce metastatic tumor burden by >12-fold. Here, we discuss these new findings and place them in the context of several other recent studies showing that oxidative stress directly contributes to tumor progression and metastasis. These results have important clinical and translational significance, as most current chemo-therapeutic agents and radiation therapy increase oxidative stress, and therefore could help drive tumor recurrence and metastasis. Similarly, chemo- and radiation-therapy both increase the risk for developing a secondary malignancy, such as leukemia and/or lymphoma. To effectively reduce mitochondrial oxidative stress, medical oncologists should now re-consider the use of powerful anti-oxidants as a key component of patient therapy and cancer prevention. Please see related research article: www.biomedcentral.com/1471-2407/11/191
|
|
|
Post by beebs on Jun 12, 2011 13:38:38 GMT -5
Dr Burzunski, has been vilified and attacked by the establishment over the years. He was branded a quack. At one time, he was sentenced to 200 years in prison. WHY? Because he was curing cancer patients. Not good practice for Big Pharma ;D there is a doc somewhere on the site which explains in more details what he does. Dr B was on national news in the USA recently, hailed as a "hero", lol, yep, from quack to hero!! Dr Burzunksi theory and lifetime work focuses on antineoplaston, peptides we naturally produce in the body, other acids including amino acids. This site was started by his cured patients: www.burzynskipatientgroup.org/Watch this documentary about Dr Burzunsky's trials and tribulations, and VICTORY... persecuted, for curing late stage cancers in many of his patients. In anycase, his high success rate speaks for itself. Free to watch until 11 June 2011.articles.mercola.com/sites/articles/archive/2011/06/11/burzynski-the-movie.aspx
|
|
|
Post by beebs on Jun 14, 2011 5:02:28 GMT -5
Copied and pasted, I haven't had the time/energy to look up this particular herb. Cancer-blocking herb to be taken off shelves in Europe email to friend Printer friendly 09 March 2011 A herb used in Traditional Chinese Medicine (TCM) can block cancer growth, researchers have discovered this week – and it’s about to disappear from stores throughout Europe. The herb, thunder god vine (lei gong teng), has been used for centuries by TCM as a remedy for rheumatoid arthritis. But researchers from Johns Hopkins School of Medicine say it can also stop tumour growth. Its active ingredient, triptolide, is an anti-inflammatory, an immunosuppressant, contraceptive – and anti-tumour agent, says Jun Liu, professor of pharmacology and molecular sciences. Yet, on May 1, it will disappear from the shelves around Europe under an EU directive that will dramatically reduce the range of herbal remedies we can buy. Every single remedy from TCM, Ayurvedic and Amazonian medical traditions will disappear under the EU’s Traditional Herbal Medicinal Products Directive. Of the hundreds of remedies currently available, just 79 will survive – and a pharmaceutical company manufactures a third of these. In laboratory tests, low doses of thunder god vine blocked cell growth in 60 different types of cancer, and even killed off some cancers. (Source: Nature Chemical Biology, 2011; 7: 182). www.wddty.com/cancer-blocking-herb-to-be-taken-off-shelves-in-europe.html
|
|
|
Post by beebs on Jul 19, 2011 9:21:58 GMT -5
From "The Oncologist" another mix of Chinese Herb lessening damage from Chemo. Those I personally know and met, except for one person, all are dying or died of the effects and side effects of chemo, steroids, and other drugs. Not of cancer(s).... I met some who tried chemo, survived the onslaught but developed either the same cancer or other cancers a few years later.
One person I know, had chemo treatment, twice. The cancer returned for a third time. She opted out of Chemo and Radio and other drugs, underwent Theta Healing two years ago, along with vits and supps. She remains cancer free.
What I wrote does not reflect my own personal view, although, I have to say, that I would never choose chemo and radio as a form of treatment for cancer. There are many herbs which are chemotherapeutic, which I would not use those either. Several chemo drugs use compounds from those herbs. Same principle and can have nasty side effects too.
(Source: The Oncologist, 2011; 16: doi: 10.1634/theoncologist.2011-0150).
Chinese herb reduces devastating effects of chemotherapy
18 July 2011 When it comes to breast cancer therapy, the treatment can be every bit as frightening as the disease itself – but it doesn’t have to be. A new study has discovered that a herb from Chinese medicine can reduce the life-threatening effects of chemotherapy, and support the patient’s immune system.
Cancer patients who were given the Chinese herbal remedy LCS101 – which is made up of 14 different herbs – lost fewer red and white blood cells during chemotherapy, and nobody reported any adverse reactions to the herbs. LCS101 was tested on 65 breast cancer patients at the Tel Aviv Sourasky Medical Centre who were given 6g capsules two weeks before chemotherapy started and during treatment.
The herbs also reduced damage to the white blood cells, which play an important role in preventing infection.
|
|
|
Post by beebs on Dec 18, 2011 15:12:59 GMT -5
|
|
|
Post by Admin on Dec 27, 2011 9:21:13 GMT -5
News about bromelain, not only as a blood thinner, also with cancer fighting properties:
Abstract Title:
In vivo antitumoral activity of stem pineapple (Ananas comosus) bromelain. Abstract Source:
Planta Med. 2007 Oct;73(13):1377-83. Epub 2007 Sep 24. PMID: 17893836 Abstract Author(s):
Roxana Báez, Miriam T Lopes, Carlos E Salas, Martha Hernández Abstract:
Stem bromelain (EC 3.4.22.32) is a major cysteine proteinase, isolated from pineapple ( Ananas comosus) stem. Its main medicinal use is recognized as digestive, in vaccine formulation, antitumoral and skin debrider for the treatment of burns. To verify the identity of the principle in stem fractions responsible for the antitumoral effect, we isolated bromelain to probe its pharmacological effects. The isolated bromelain was obtained from stems of adult pineapple plants by buffered aqueous extraction and cationic chromatography. The homogeneity of bromelain was confirmed by reverse phase HPLC, SDS-PAGE and N-terminal sequencing. The in vivo antitumoral/antileukemic activity was evaluated using the following panel of tumor lines: P-388 leukemia, sarcoma (S-37), Ehrlich ascitic tumor (EAT), Lewis lung carcinoma (LLC), MB-F10 melanoma and ADC-755 mammary adenocarcinoma. Intraperitoneal administration of bromelain (1, 12.5, 25 mg/kg), began 24 h after tumor cell inoculation in experiments in which 5-fluorouracil (5-FU, 20 mg/kg) was used as positive control. The antitumoral activity was assessed by the survival increase (% survival index) following various treatments. With the exception of MB-F10 melanoma, all other tumor-bearing animals had a significantly increased survival index after bromelain treatment. The largest increase ( approximately 318 %) was attained in mice bearing EAT ascites and receiving 12.5 mg/kg of bromelain. This antitumoral effect was superior to that of 5-FU, whose survival index was approximately 263 %, relative to the untreated control. Bromelain significantly reduced the number of lung metastasis induced by LLC transplantation, as observed with 5-FU. The antitumoral activity of bromelain against S-37 and EAT, which are tumor models sensitive to immune system mediators, and the unchanged tumor progression in the metastatic model suggests that the antimetastatic action results from a mechanism independent of the primary antitumoral effect. Pubmed Data : Planta Med. 2007 Oct;73(13):1377-83. Epub 2007 Sep 24. PMID: 17893836
Article Published Date : Oct 01, 2007 Study Type : Animal Study Additional Links Substances : Bromelain : CK(145) : AC(34), Pineapple : CK(130) : AC(39)
Diseases : Cancer Metastasis : CK(229) : AC(120), Lung Cancer : CK(425) : AC(182)
Pharmacological Actions : Anti-metastatic : CK(153) : AC(95) Additional Keywords : Drug: 5-flourouracil : CK(68) : AC(23), Food as Medicine : CK(13) : AC(6), Hall of Fame : CK(30) : AC(6), Superiority of Natural Substances versus Drugs : CK(824) : AC(172)
|
|
|
Post by beebs on Dec 27, 2011 10:56:03 GMT -5
Mangoosteen is not the fruit yielding compounds for melanoma, there are other fruits and vegetables, do your research. Cytotoxic effect of xanthones from pericarp of the tropical fruit mangosteen (Garcinia mangostana Linn.) on human melanoma cells. Wang JJ, Sanderson BJ, Zhang W. Source Level 4, Health Science Building, Department of Medical Biotechnology, Flinders Medical Sciences and Technology, School of Medicine, Faculty of Health Science, Flinders University, Registry Road, Bedford Park, Adelaide 5042, Australia. wang0524@flinders.edu.au Abstract Mangosteen (Garcinia mangostana Linn.) is a tropical tree from South East Asia and its fruit pericarp is a well-known traditional medicine. In this study, the cytotoxic effect of three xanthone compounds (α-mangostin, γ-mangostin, and 8-deoxygartanin) from mangosteen pericarp was investigated using the human melanoma SK-MEL-28 cell line. Significant dose-dependent reduction in % cell viability was induced. γ-Mangostin and 8-deoxygartanine at 5 μg/ml increased the cell cycle arrest in G(1) phase (90% and 92%) compared with untreated cells (78%). All compounds induced apoptosis, of the highest being α-mangostin at 7.5 μg/ml that induced 59.6% early apoptosis, compared to 1.7% in untreated cells. The apoptotic effect of α-mangostin was via caspase activation and disruption of mitochondrial membrane pathways as evidenced by 25-fold increased caspase-3 activity and 9-fold decreased mitochondrial membrane potential when compared to untreated cells. In conclusion, these xanthones, especially α-mangostin, are potential candidates as anti-melanoma agents. www.ncbi.nlm.nih.gov/pubmed/21723363
|
|
|
Post by beebs on Dec 27, 2011 11:18:33 GMT -5
Two articles concerning the chemical compounds showing anti cancer properties of cranberries. North American cranberry (Vaccinium macrocarpon) stimulates apoptotic pathways in DU145 human prostate cancer cells in vitro.MacLean MA, Scott BE, Deziel BA, Nunnelley MC, Liberty AM, Gottschall-Pass KT, Neto CC, Hurta RA. Source Department of Biology, University of Prince Edward Island, Charlottetown, Prince Edward Island, Canada. Abstract Diets rich in fruits and vegetables have been shown to improve patient prognosis in a variety of cancers, a benefit partly derived from phytochemicals, many of which target cell death pathways in tumor cells. Cranberries (Vaccinium macrocarpon) are a phytochemical-rich fruit containing a variety of polyphenolic compounds. As flavonoids have been shown to induce apoptosis in human tumor cells, this study investigated the hypothesis that cranberry-mediated cytotoxicity in DU145 human prostate adenocarcinoma cells involves apoptosis. The results showed that induction of apoptosis in these cells occurred in response to treatment with whole cranberry extract and occurred through caspase-8 mediated cleavage of Bid protein to truncated Bid resulting in cytochrome-C release from the mitochondria. Subsequent activation of caspase-9 ultimately resulted in cell death as characterized by DNA fragmentation. Increased Par-4 protein expression was observed, and this is suggested to be at least partly responsible for caspase-8 activation. Proanthocyanidin-enriched and flavonol-enriched fractions of cranberry also increased caspase-8 and caspase-9 activity, suggesting that these compounds play a possible role in apoptosis induction. These findings indicate that cranberry phytochemicals can induce apoptosis in prostate cancer cells in vitro, and these findings further establish t he potential value of cranberry phytochemicals as possible agents against prostate cancer. www.ncbi.nlm.nih.gov/pubmed/21161819Anticancer activities of cranberry phytochemicals: an update.Neto CC, Amoroso JW, Liberty AM. Source Department of Chemistry and Biochemistry, University of Massachusetts Dartmouth, North Dartmouth, MA 02747, USA. cneto@umassd.edu Abstract Studies employing mainly in vitro tumor models show that extracts and compounds isolated from cranberry fruit (Vaccinium macrocarpon) inhibit the growth and proliferation of several types of tumor including breast, colon, prostate, and lung. Proanthocyanidin oligomers, flavonol and anthocyanin glycosides and triterpenoids are all likely contributors to the observed anticancer properties and may act in a complementary fashion to limit carcinogenesis. Possible chemopreventive mechanisms of action by cranberry phytochemicals include induction of apoptosis in tumor cells, reduced ornithine decarboxylase activity, decreased expression of matrix metalloproteinases associated with prostate tumor metastasis, and anti-inflammatory activities including inhibition of cyclooxygenases. A review of recent studies suggests a potential role for cranberry as a dietary chemopreventive and provides direction for future research.
|
|
|
Post by beebs on Jan 10, 2012 16:58:10 GMT -5
Antimetastic compound in pineapple..
Bromelain has antimetastic protential as demonstrated in lung cancer cells - Article 1. - GreenMedInfo Summary Abstract Title:
Antimetastatic effect of bromelain with or without its proteolytic and anticoagulant activity. Abstract Source:
J Cancer Res Clin Oncol. 1988;114(5):507-8. PMID: 3182910 Abstract Author(s):
S Batkin, S J Taussig, J Szekerezes Abstract:
Bromelain, a pineapple-derived plant product, added to C57Bl/6 mice laboratory chow decreased lung metastasis of Lewis lung cancer cells implanted s.c. This antimetastatic potential was demonstrated by both the active and inactive bromelain with or without proteolytic, anticoagulant properties.
Pubmed Data : J Cancer Res Clin Oncol. 1988;114(5):507-8. PMID: 3182910
|
|
|
Post by beebs on Jan 17, 2012 12:50:03 GMT -5
Avocado raises glutathione, contains healthy fatty acids, tocopherols, chemopreventive, antimicrobial... Biochem Biophys Res Commun. 2011 Jun 10;409(3):465-9. Epub 2011 May 8. Aliphatic acetogenin constituents of avocado fruits inhibit human oral cancer cell proliferation by targeting the EGFR/RAS/RAF/MEK/ERK1/2 pathway.D'Ambrosio SM, Han C, Pan L, Kinghorn AD, Ding H. Source Department of Radiology, College of Medicine, The Ohio State University, Columbus, OH 43210, USA. Abstract Avocado (Persea americana) fruits are consumed as part of the human diet and extracts have shown growth inhibitory effects in various types of human cancer cells, although the effectiveness of individual components and their underlying mechanism are poorly understood. Using activity-guided fractionation of the flesh of avocado fruits, a chloroform-soluble extract (D003) was identified that exhibited high efficacy towards premalignant and malignant human oral cancer cell lines. From this extract, two aliphatic acetogenins of previously known structure were isolated, compounds 1 [(2S,4S)-2,4-dihydroxyheptadec-16-enyl acetate] and 2 [(2S,4S)-2,4-dihydroxyheptadec-16-ynyl acetate]. In this study, we show for the first time that the growth inhibitory efficacy of this chloroform extract is due to blocking the phosphorylation of EGFR (Tyr1173), c-RAF (Ser338), and ERK1/2 (Thr202/Tyr204) in the EGFR/RAS/RAF/MEK/ERK1/2 cancer pathway. Compounds 1 and 2 both inhibited phosphorylation of c-RAF (Ser338) and ERK1/2 (Thr202/Tyr204). Compound 2, but not compound 1, prevented EGF-induced activation of the EGFR (Tyr1173). When compounds 1 and 2 were combined they synergistically inhibited c-RAF (Ser338) and ERK1/2 (Thr202/Tyr204) phosphorylation, and human oral cancer cell proliferation. The present data suggest that the potential anticancer activity of avocado fruits is due to a combination of specific aliphatic acetogenins that target two key components of the EGFR/RAS/RAF/MEK/ERK1/2 cancer pathway. www.ncbi.nlm.nih.gov/pubmed/21596018
|
|
|
Post by beebs on May 1, 2012 7:13:38 GMT -5
Boswellia has been used for thousands of years by Ayurvedic doctors.. how much longer will we have to wait to validate therapeutic benefits in the West? The article discusses the benefits of Boswellia includes the mechanism by which it inhibits cancer cell proliferation and apoptosis. Easy read.. www.lef.org/magazine/mag2011/ss2011_Neutralize-a-Lethal-Enzyme_02.htm
|
|
|
Post by beebs on Jun 4, 2012 5:08:45 GMT -5
Following an earlier post about Graviola, the YT vid is a lead to other other links:
|
|
|
Post by beebs on Jul 21, 2012 16:01:18 GMT -5
Article discusses mangosteen fruit rind for colon cancer looks promising. Anecdotal: I know a few people are using mangosteen and other dietary compounds for their cancers, successfully. In vitro and in vivo anti-colon cancer effects of Garcinia mangostana xanthones extractAbdalrahim FA Aisha, Khalid M Abu-Salah, Zhari Ismail and Amin Malik Shah Abdul Majid For all author emails, please log on. BMC Complementary and Alternative Medicine 2012, 12:104 doi:10.1186/1472-6882-12-104 Published: 20 July 2012 Abstract (provisional) Background Xanthones are a group of oxygen-containing heterocyclic compounds with remarkable pharmacological effects such as anti-cancer, antioxidant, anti-inflammatory, and antimicrobial activities. Methods A xanthones extract (81% alpha-mangostin and 16% gamma-mangostin), was prepared by crystallization of a toluene extract of G. mangostana fruit rinds and was analyzed by LC-MS. Anti-colon cancer effect was investigated on HCT 116 human colorectal carcinoma cells including cytotoxicity, apoptosis, anti-tumorigenicity, and effect on cell signalling pathways. The in vivo anti-colon cancer activity was also investigated on subcutaneous tumors established in nude mice. Results The extract showed potent cytotoxicity (median inhibitory concentration 6.5+/-1.0 ug/ml), due to induction of the mitochondrial pathway of apoptosis. Three key steps in tumor metastasis including the cell migration, cell invasion and clonogenicity, were also inhibited. The extract and alpha-mangostin up-regulate the MAPK/ERK, c-Myc/Max, and p53 cell signalling pathways. The xanthones extract, when fed to nude mice, caused significant growth inhibition of the subcutaneous tumor of HCT 116 colorectal carcinoma cells. Conclusions Our data suggest new mechanisms of action of alpha-mangostin and the G. mangostana xanthones, and suggest the xanthones extract of as a potential anti-colon cancer candidate. vandhttp://www.biomedcentral.com/1472-6882/12/104/abstract
|
|
|
Post by beebs on Jul 26, 2012 14:38:40 GMT -5
Article about Vit C and K3 for prostate cancer. The earliest one I found was in 1999, there may be others. Phase I and II trial of Vit C + K3 shows some success with end stage patients. Pity it didn't include early stage prostate cancer, and no adjunct therapy!! www.ncbi.nlm.nih.gov/pubmed/18392145Altern Med Rev. 2010 Dec;15(4):345-51. The vitamin C:vitamin K3 system - enhancers and inhibitors of the anticancer effect. Lamson DW, Gu YH, Plaza SM, Brignall MS, Brinton CA, Sadlon AE. Source Bastyr University, Kenmore, WA, USA. davisl@seanet.com Abstract The oxidizing anticancer system of vitamin C and vitamin K₃ (VC:VK₃, producing hydrogen peroxide via superoxide) was combined individually with melatonin, curcumin, quercetin, or cholecalciferol (VD₃) to determine interactions. Substrates were LNCaP and PC-3 prostate cancer cell lines. Three of the tested antioxidants displayed differences in cell line cytotoxicity. Melatonin combined with VC:VK₃ quenched the oxidizing effect, while VC:VK₃ applied 24 hours after melatonin showed no quenching. With increasing curcumin concentrations, an apparent combined effect of VC:VK₃ and curcumin occurred in LNCaP cells, but not PC-3 cells. Quercetin alone was cytotoxic on both cell lines, but demonstrated an additional 50-percent cytotoxicity on PC-3 cells when combined with VC:VK₃. VD₃ was effective against both cell lines, with more effect on PC-3. This effect was negated on LNCaP cells with the addition of VC:VK₃. In conclusion, a natural antioxidant can enhance or decrease the cytotoxicity of an oxidizing anticancer system in vitro, but generalizations about antioxidants cannot be made. www.ncbi.nlm.nih.gov/pubmed/21194250
|
|
|
Post by beebs on Sept 19, 2012 13:12:34 GMT -5
Worthwhile news to share. My sister received the all clear for breast cancer, for the second year. She used only intensive nutritional therapy, meditation and lifestyle modification, baed on Dr I Gawler's protocol. She didn't use vits and supps, nor did she use any other therapeutic modlaities. Well done, Sis. Was it a fluke?? NOT. I met many others, some with stage IV various cancers, who took matters in their own hands, lived to tell the tale, CANCER FREE...The next task is to ensure it does not return. Compounds causing cancer cells apoptosis are well accepted within scientific community. Cloves is ranked as being one of the highest containing antioxidants foods. The articles below discusses eugenol, also found in other foods, as cancer cells apoptosis. Molecules. 2012 May 25;17(6):6290-304. Antiproliferative and molecular mechanism of eugenol-induced apoptosis in cancer cells.Jaganathan SK, Supriyanto E. Source Department of Biomedical Engineering, PSNA college of Engineering and Technology, Kothandaraman Nagar, Dindigul 624622, Tamil Nadu, India. jaganathaniitkgp@gmail.com Abstract Phenolic phytochemicals are a broad class of nutraceuticals found in plants which have been extensively researched by scientists for their health-promoting potential. One such a compound which has been comprehensively used is eugenol (4-allyl-2-methoxyphenol), which is the active component of Syzigium aromaticum (cloves). Aromatic plants like nutmeg, basil, cinnamon and bay leaves also contain eugenol. Eugenol has a wide range of applications like perfumeries, flavorings, essential oils and in medicine as a local antiseptic and anesthetic. Increasing volumes of literature showed eugenol possesses antioxidant, antimutagenic, antigenotoxic, anti-inflammatory and anticancer properties. Molecular mechanism of eugenol-induced apoptosis in melanoma, skin tumors, osteosarcoma, leukemia, gastric and mast cells has been well documented. This review article will highlight the antiproliferative activity and molecular mechanism of the eugenol induced apoptosis against the cancer cells and animal models. www.ncbi.nlm.nih.gov/pubmed/22634840
|
|
|
Post by beebs on Sept 23, 2012 13:58:26 GMT -5
|
|
|
Post by beebs on Sept 28, 2012 17:19:43 GMT -5
Comment: a while back, I was looking at rice bran capsules. Expensive!! Recent reports show US rice containing higher safety level of arsenic.
Adv Nutr. 2012 Sep 1;3(5):643-53. doi: 10.3945/an.112.002303. Chemopreventive properties of dietary rice bran: current status and future prospects. Henderson AJ, Ollila CA, Kumar A, Borresen EC, Raina K, Agarwal R, Ryan EP. Source
Department of Clinical Sciences, Colorado State University, Fort Collins, CO. Abstract
Emerging evidence suggests that dietary rice bran may exert beneficial effects against several types of cancer, such as breast, lung, liver, and colorectal cancer. The chemopreventive potential has been related to the bioactive phytochemicals present in the bran portion of the rice such as ferulic acid, tricin, β-sitosterol, γ-oryzanol, tocotrienols/tocopherols, and phytic acid. Studies have shown that the anticancer effects of the rice bran-derived bioactive components are mediated through their ability to induce apoptosis, inhibit cell proliferation, and alter cell cycle progression in malignant cells.
Rice bran bioactive components protect against tissue damage through the scavenging of free radicals and the blocking of chronic inflammatory responses. Rice bran phytochemicals have also been shown to activate anticancer immune responses as well as affecting the colonic tumor microenvironment in favor of enhanced colorectal cancer chemoprevention. This is accomplished through the modulation of gut microflora communities and the regulation of carcinogen-metabolizing enzymes.
In addition, the low cost of rice production and the accessibility of rice bran make it an appealing candidate for global dietary chemoprevention. Therefore, the establishment of dietary rice bran as a practical food-derived chemopreventive agent has the potential to have a significant impact on cancer prevention for the global population.
|
|
|
Post by beebs on Nov 2, 2012 14:43:30 GMT -5
Douche combo for cervical cancer reduction, may help may not.
For herbal douche, use spring water, and dilute with 3 %hydrogen peroxide and apple cider vinegar (both optional)
Boil 1 pint of water. Add 2 1/2 tablespoons of red clover tea Let seep for 20 mins
Same for Chaparal tea. Set aside let seep overnight for 8 to 10 hours.
NB. vaginal teas should be room temperature, NEVER cold!!
Excerpt from Heinerman's Encyclopedia of Juices Teas & Tonics
|
|
|
Post by beebs on Nov 8, 2012 7:32:09 GMT -5
Frankincense Oil (FO) from resin extracted from Boswellia carteri and Boswellia serrata trees, have been found to contain anti neoplastons compounds. These are used in Ayurvedic Medicine for cancer, immune modulators, arthritis, anti bacterial, anti fungal, etc.. (see previous posts). They selectively cause cancer cells death, reversed brain metastases from breast cancer observed in one patient. The paper conclude that FO can be used as an alternative treatment to bladder cancer: www.ncbi.nlm.nih.gov/pmc/articles/PMC2664784/
|
|
|
Post by beebs on Nov 21, 2012 15:32:06 GMT -5
Smokers and Ex-Smokers beware of Curcumin: Lung tumor promotion by curcumin.Dance-Barnes ST, Kock ND, Moore JE, Lin EY, Mosley LJ, D'Agostino RB Jr, McCoy TP, Townsend AJ, Miller MS. Source Department of Cancer Biology, Comprehensive Cancer Center, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA. Erratum in Carcinogenesis. 2010 Oct;31(10):1903. Dosage error in published abstract; MEDLINE/PubMed abstract corrected; Dosage error in article text. Abstract Curcumin exhibits anti-inflammatory and antitumor activity and is being tested in clinical trials as a chemopreventive agent for colon cancer. Curcumin's chemopreventive activity was tested in a transgenic mouse model of lung cancer that expresses the human Ki-ras(G12C) allele in a doxycycline (DOX) inducible and lung-specific manner. The effects of curcumin were compared with the lung tumor promoter, butylated hydroxytoluene (BHT), and the lung cancer chemopreventive agent, sulindac. Treatment of DOX-induced mice with dietary curcumin increased tumor multiplicity (36.3 +/- 0.9 versus 24.3 +/- 0.2) and progression to later stage lesions, results which were similar to animals that were co-treated with DOX/BHT. Microscopic examination showed that the percentage of lung lesions that were adenomas and adenocarcinomas increased to 66% in DOX/BHT, 66% in DOX/curcumin and 49% in DOX/BHT/curcumin-treated groups relative to DOX only treated mice (19%). Immunohistochemical analysis also showed increased evidence of inflammation in DOX/BHT, DOX/curcumin and DOX/BHT/curcumin mice relative to DOX only treated mice. In contrast, co-treatment of DOX/BHT mice with 200 p.p.m. [DOSAGE ERROR CORRECTED] of sulindac inhibited the progression of lung lesions and reduced the inflammation. Lung tissue from DOX/curcumin-treated mice demonstrated a significant increase (33%; P = 0.01) in oxidative damage, as assessed by the levels of carbonyl protein formation, relative to DOX-treated control mice after 1 week on the curcumin diet. These results suggest that curcumin may exhibit organ-specific effects to enhance reactive oxygen species formation in the damaged lung epithelium of smokers and ex-smokers. Ongoing clinical trials thus may need to exclude smokers and ex-smokers in chemopreventive trials of curcumin. www.ncbi.nlm.nih.gov/pubmed/19359593?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum&ordinalpos=19
|
|
|
Post by Admin on Nov 26, 2012 11:35:23 GMT -5
|
|
|
Post by beebs on Dec 16, 2012 17:05:00 GMT -5
Check out other articles about pancreatic cancer and Frankincense (Boswellia). The study shows promising results: Frankincense essential oil prepared from hydrodistillation of Boswellia sacra gum resins induces human pancreatic cancer cell death in cultures and in a xenograft murine modelXiao Ni, Mahmoud M Suhail, Qing Yang, Amy Cao, Kar-Ming Fung, Russell G Postier, Cole Woolley, Gary Young, Jingzhe Zhang and Hsueh-Kung Lin BMC Complementary and Alternative Medicine 2012, 12:253 doi:10.1186/1472-6882-12-253 Published: 13 December 2012 Abstract (provisional) Background Regardless of the availability of therapeutic options, the overall 5-year survival for patients diagnosed with pancreatic cancer remains less than 5%. Gum resins from Boswellia species, also known as frankincense, have been used as a major ingredient in Ayurvedic and Chinese medicine to treat a variety of health-related conditions. Both frankincense chemical extracts and essential oil prepared from Boswellia species gum resins exhibit anti-neoplastic activity, and have been investigated as potential anti-cancer agents. The goals of this study are to identify optimal condition for preparing frankincense essential oil that possesses potent anti-tumor activity, and to evaluate the activity in both cultured human pancreatic cancer cells and a xenograft mouse cancer model.Methods Boswellia sacra gum resins were hydrodistilled at 78 [degree sign]C; and essential oil distillate fractions were collected at different durations (Fraction I at 0--2 h, Fraction II at 8--10 h, and Fraction III at 11--12 h). Hydrodistillation of the second half of gum resins was performed at 100 [degree sign]C; and distillate was collected at 11--12 h (Fraction IV). Chemical compositions were identified by gas chromatography--mass spectrometry (GC-MS); and total boswellic acids contents were quantified by high-performance liquid chromatography (HPLC). Frankincense essential oil-modulated pancreatic tumor cell viability and cytotoxicity were determined by colorimetric assays. Levels of apoptotic markers, signaling molecules, and cell cycle regulators expression were characterized by Western blot analysis. A heterotopic (subcutaneous) human pancreatic cancer xenograft nude mouse model was used to evaluate anti-tumor capability of Fraction IV frankincense essential oil in vivo. Frankincense essential oil-induced tumor cytostatic and cytotoxic activities in animals were assessed by immunohistochemistry. Results Longer duration and higher temperature hydrodistillation produced more abundant high molecular weight compounds, including boswellic acids, in frankincense essential oil fraactions. Human pancreatic cancer cells were sensitive to Fractions III and IV (containing higher molecular weight compounds) treatment with suppressed cell viability and increased cell death. Essential oil activated the caspase-dependent apoptotic pathway, induced a rapid and transient activation of Akt and Erk1/2, and suppressed levels of cyclin D1 cdk4 expression in cultured pancreatic cancer cells. In addition, Boswellia sacra essential oil Fraction IV exhibited anti-proliferative and pro-apoptotic activities against pancreatic tumors in the heterotopic xenograft mouse model. Conclusion All fractions of frankincense essential oil from Boswellia sacra are capable of suppressing viability and inducing apoptosis of a panel of human pancreatic cancer cell lines. Potency of essential oil-suppressed tumor cell viability may be associated with the greater abundance of high molecular weight compounds in Fractions III and IV. Although chemical component(s) responsible for tumor cell cytotoxicity remains undefined, crude essential oil prepared from hydrodistillation of Boswellia sacra gum resins might be a useful alternative therapeutic agent for treating patients with pancreatic adenocarcinoma, an aggressive cancer with poor prognosis. www.biomedcentral.com/1472-6882/12/253/abstract
|
|
|
Post by beebs on Jul 25, 2013 14:30:20 GMT -5
Int J Oncol. 2010 Nov;37(5):1331-8. Hedyotis Diffusa Willd extract induces apoptosis via activation of the mitochondrion-dependent pathway in human colon carcinoma cells.Lin J, Chen Y, Wei L, Chen X, Xu W, Hong Z, Sferra TJ, Peng J. Source Fujian Academy of Integrative Medicine, Fujian University of Traditional Chinese Medicine, Minhou Shangjie, Fuzhou, Fujian 350108, P.R. China. Abstract Hedyotis Diffusa Willd has been used as a major component in several Chinese medicine formulations for the clinical treatment of colorectal cancer. However, the molecular mechanism of the anti-cancer activity of Hedyotis Diffusa Willd remains unclear. In the present study, we investigated the cellular effects of the ethanol extract of Hedyotis Diffusa Willd (EEHDW) in the HT-29 human colon carcinoma cell line. We found that EEHDW inhibited the growth of HT-29 cells demonstrating EEHDW-induced cell morphological changes and reduced cell viability in a dose- and time-dependent manner. Furthermore, we observed that EEHDW treatment resulted in DNA fragmentation, loss of plasma membrane asymmetry, collapse of mitochondrial membrane potential, activation of caspase-9 and caspase-3, and increase of the ratio of pro-apoptotic Bax to anti-apoptotic Bcl-2, suggesting that the HT-29 cell growth inhibitory activity of EEHDW was due to mitochondrion-mediated apoptosis, which may partly explain the anti-cancer activity of Hedyotis Diffusa Willd. www.ncbi.nlm.nih.gov/pubmed/20878081
|
|
|
Post by Admin on Aug 31, 2013 17:52:11 GMT -5
Afraid of a cancer diagnosis? According to recent articles in various medical journals, cancers can self destruct through various unknown mechanisms. Some oncologists advise against surgery because it can spread, often, removing polyps leads to rapid spread shortening patients lives. Discussions about cancer patients going in spontaneous remission without meds. I met hundreds of cancer sufferers who chose nutrition and various non-allopathic models, in remission, some, as long as 20 years, and others life time. The article and short vid shows how little we know about cancer. What we do know, is that it is reversible, and manageable, much ignored by chemo/radio brigade worth billions in revenue. Vid or article: Short vid on Medscape: www.medscape.com/viewarticle/809982Excerpt from the article: Cancer cells -- anaplastic, dedifferentiated, capable of autonomous growth, utterly out of control until destroying their host -- are, however, not just one thing. We are learning more every day that cancer is many different diseases, even thousands or tens of thousands of different diseases. For a long time, it made sense to try to eradicate all cancers, as early and as completely as possible. Mass efforts were launched to find cancers wherever they were and destroy them. Since the earliest cancers seemed to evolve from some identifiable premalignant conditions, wouldn't it make sense to also nip those in the bud? Sounds logical. But, as with many exuberant efforts, this one got out of control. Many lesions that were called "cancer" really were not cancers at all in behavior, and this fact began to be recognized in large numbers of patients. These unfortunate victims have experienced massive psychological and physical harm and costs without any clear benefits achieved by finding and treating their "noncancers."
|
|
|
Post by beebs on Mar 6, 2014 11:18:14 GMT -5
The articles discusses paw paw from one specific called Asimina tribola, which helps healthy cells regeneration.
According to this study, extraction from the twig prevents RNA DNA replication to cancer cells, (stops from reproducing) promotes anti-angiogenesis - inhibits new blood vessels from forming, cutting off supplies to cancer cells. Will by pass the multiple drug resistance pump (MDR), to allow the paw paw through, and inhibit ATP to cancer cells, cancer cells consume up to 17% energy than normal cells.
Look up foods that have angio-angiogenesis effects such as garlic, green tea, red wine, garlic etc. Antineoplaston foods are helpful. (Not mentioned in the article).
Note that in isolation, it may not work, needed is protease, fatty acids Omega 3,6, 7, & 9, minerals, immune adaptogen, digestive cleansing, keeping pH higher than at least 6.5, avoid all environmental toxicities.
Read up on paw paw leaves too.
J Nat Prod. 2008 Jul;71(7):1311-21. doi: 10.1021/np800191t. Epub 2008 Jul 4. Paw paw and cancer: annonaceous acetogenins from discovery to commercial products. McLaughlin JL. Author information Abstract
Extracts of paw paw ( Asimina triloba, Annonaceae) are among the most potent of the 3500 species of higher plants screened for bioactive compounds in our laboratories at Purdue University. The paw paw is a small tree native to eastern North America; its edible fruits (sometimes referred to as "Indiana Bananas") have nurtured mankind for centuries. Activity-directed fractionation of the paw paw extracts, using the brine shrimp lethality bioassay, led to the isolation and molecular characterization of over 50 unique annonaceous acetogenins. Fractionation of extracts from related species resulted in the identification of over 150 additional acetogenins. The annonaceous acetogenins are derivatives of long-chain (C32 or C34) fatty acids. They are potent inhibitors of mitochondrial (complex I) as well as cytoplasmic (anaerobic) production of adenosine triphosphate (ATP) and the related nucleotides. The powerful cytotoxicity, in vivo antitumor, pesticidal, antimalarial, anthelmintic, piscicidal, antiviral, and antimicrobial effects indicated a myriad of potentially useful applications. Commercial development of these compounds uses natural mixtures of active components, incorporated into pesticidal, topical, and dietary supplement products. Successful applications and commercial products include a shampoo, highly effective in treating infestations of head lice, fleas, and ticks; a series of pesticidal sprays, which protects host plants against a diversity of pests; and an ointment for treatment of oral herpes (HSV-1) and other skin afflictions. The extract (in capsule form) enhances a mixture of natural anthelmintics. In addition, an encapsulated extract has been effectively used by certain cancer patients as a botanical supplement product.
PMID: 18598079 [PubMed - indexed for MEDLINE]
|
|