Post by beebs on May 6, 2011 9:50:02 GMT -5
Reading up on ginger led me to Magnolia Bark.
REad the first post to make the connection:
health-quest.proboards.com/index.cgi?board=cnspnsans&action=display&thread=76&page=1
Plenty of studies supporting Magnolia Bark's GABAergic properties. I will say this again, if the Chinese have using this for thousands of years successfully to treat CNS issues, I wouldl not wait for the Medical Establishment and BiG Pharma to appropriate of the compounds in Magnolia Bark mix it with their lethal toxic addictive chems..
The first abstract shows some of the mechanism by which its suppose to work one of which is to allows for tansmission of Chloride ions. Same as with Benzos, except, not addictive and no side effects. Anyway,when the Magnolia Bark or Benzo binds to the GABA A receptor, and its allows for more chloride ions, it inhibits GABA, and lessens neuronal firing.
Given the choice, its a "no-brainer" ;D
Some studies below, and see more here: www.ncbi.nlm.nih.gov/pubmed?term=magnolia%20officinialis
Anxiolytic-Like Effects of 4-O-Methylhonokiol Isolated from Magnolia officinalis Through Enhancement of GABAergic Transmission and Chloride Influx.
Han H, Jung JK, Han SB, Nam SY, Oh KW, Hong JT.
Source
1 College of Pharmacy, Chungbuk National University , Cheongju, Korea .
Abstract
Abstract This study investigated the anxiolytic-like effects of 4-O-methylhonokiol, a neolignan compound of Magnolia officinalis, by using the experimental paradigms of anxiety and compared the results with those of a known anxiolytic, diazepam. A single treatment with 4-O-methylhonokiol (0.1, 0.2, and 0.5 mg/kg, p.o.) or treatment for 7 days (0.5 mg/kg in drinking water) increased the percentage of time spent in the open arms and the number of open arms entries in the elevated plus-maze test. However, the 4-O-methylhonokiol-increased percentage of time spent in the open arm was abolished by treatment with flumazenil, a benzodiazepine receptor antagonist (10 mg/kg). 4-O-Methylhonokiol also increased the number of head dips in the hole-board test, but decreased locomotor activity. Molecular experiments revealed that the α1-subunit of γ-aminobutyric acid (GABA) type A receptors was overexpressed in the cortex of brains of mice after treatment with 4-O-methylhonokiol for 7 days. In addition, 4-O-methylhonokiol also increased chloride influx in cultured cortical cells. It is concluded that 4-O-methylhonokiol may have anxiolytic-like effects and that these effects may be mediated by GABAergic transmission with the increase of Cl(-) channel opening. www.ncbi.nlm.nih.gov/pubmed/21501091
In addition, Magnolia Bark has compounds effective against Staph, E Coli, Candida, read about it, on PUbMed and other sources