Post by Deleted on May 5, 2011 8:27:57 GMT -5
In the article "The vanilloid receptor as a putative target of diverse chemicals in multiple chemical sensitivity" Prof. Pall writes .."The vanilloid receptor is reportedly hyperresponsive in MCS and can increase nitric oxide levels and stimulate N-methyl-D-aspartate (NMDA) receptor activity, both of which are important features in the previously proposed central role of nitric oxide and NMDA receptors in MCS"...
www.cababstractsplus.org/google/abstract.asp?AcNo=20053213236
I wanted to try to find out what else is able to activate the TRP -receptors. I depended on the substances, which I found in the literature but I am sure there are much more substances, which can activate them. Please keep in mind that I am a layman.
It is surely not easy to remember all the different substances, therefore here is a little help:
TRPV1 can be activated by things, which are as hot and pungent like chillies, or pepper.
TRPA1 can be activated by pungent things like garlic, onions and mustard oil which you can find in cabbage, radish ...I noticed over the years that several people from the quinolones scene had problems with garlic and similar food. If you have problems with these food, pay attention to the TRPA1.
Alcohol is able to activate TRPV1 in a strong way and it lowers the threshold. So things, which were in former time safe, are it no longer. So please stay away from it!
TRPV1 and TRPA1 are often expressed together. Therefore pay attention to both groups.
TRPV3 can be activated by essential oils in herbs and spices. Pay attention that camphor is changed in the body into borneol, which is 150 times stronger than camphor!
If you notice that herbs or a drug behave in a different way than expected, don’t try it a second time. For example drugs or herbs which should calm down the nervous system may activate TRP receptors and up-regulate this way the nervous system and you may become even more sensitive.
The TRPV receptor is able to release substance P which is causing pain and other substances which are able to create inflammations. Because it can be found in many areas of the body including brain, respiratory tract, digestive systems, skin, heart, bladder, joints … it can play a huge role in pain and inflammations in these areas.
I have written these lists so you have a help to decide, if this receptor family may play a role in your case.
I will try to illustrate it with an example. Imagine having 2 different persons. Person A has a nut allergy. So this person has not only to avoid nuts in general, he has to find out where they may be hidden like in chocolate, cereals… Person B has no nut allergy. Therefore he has not to avoid nuts.
In our cases we have 2 different kinds of people. We all are injured by the quinolones but only some of us may have problems with the TRP receptors and for them these lists may be a help to find out if they react against something and where it is hidden.
If you read the lists, please don’t let yourself discouraged by chemical expressions, which sound complicated. It is more important that you look, if you react more let us say against essential oils and fragrances and where they can be found.
--------------------------------------------------------------------------------
TRPV1
Capsaicin (1, 2)
hot, pungent substance in chilli (4, 5)
RTX – Resiniferatoxin (2)
It is a very strong activator of the TRPV1. You can find it in the resin of plants of the Euphorbia family. Some look like what people may call cactuses, but they are no real cactus. So please look it up in the internet. Poinsettia belongs to this class, too. (4, 5)
Zingeron (3)
Another pungent substance of ginger.
Oil of ginger is used as fixing agent in perfumes (4, 5)
Piperine (3)
pepper (4, 5)
Guaiacol (3)
Resin from Guaiacum officinale (Zygophyllaceae) and it can be found in beech wood tar.
It is used against cough. (4, 5)
Eugenol (3, 9)
It is in:
Clove, basil, materials used by the dentist, cinnamon oil (sweet food, curry powder, cosmetic, mouthwash), fragrance in soaps, jasmine oil, bay leaf, nutmeg, myrrh, patchouli oil (fixing agent in fragrances for men, soaps, cosmetic), rose oil, piment essential oil, labdanum (fixing agent for fragrances), cascarilla oil (fragrances in tobacco, and bitter liqueur), bay oil (antiseptics for skin, hair tonic) (4, 5)
Extract from the roots of Echinacea (6)
(cone flower, black Sampson)
Use: against infections and skin inflammations (4, 5)
Camphor (9)
From camphor trees (Cinnamomum camphora), which are 12 m high laurel tree
Camphor and it derivates can be found in:
Rosemary, lavender, sage, tansy, juniper, valerian, peppermint
Use: celluloid-industry, where it is used as softener;
Smokeless gunpowder, against moths, disinfectant (4, 5)
Cyclohexanone (9)
Solvent for many lacquers, polyvinylchlorid and cationic dyes, ketonic resins, admixture for paint for leather, special printing inks, remover, intermediates in the production of nylon (4, 5)
Ethanol and other alcohols (1, 12)
Propanol: disinfectant, solvent (4, 5)
Lidocain (10)
Local anaesthetic (4, 5)
Evodiamin (3)
Evodia plant is used in chinese medicine (3)
Endogenous substances and other factors
Anandamide (2,3)
Endogenous cannaboide substance (3)
N-arachidonoyldopamine,
Oleoylethanolamide
N-oleoyldopamine (2,3)
Products of the lipoxygenase (2)
Leukotriene B4 (2)
Temperature higher than 43°C – 109F (2)
ph< 5.3 acid (2)
Ginsenosides (3)
Substance from ginseng
can act acitivating and inhibiting
Substances, which inhibit the TRPV1
Thapsigargin (3)
Substance of the plant Thapsia garganica (Apiaceae)
Used against rheumatic pain (3)
Yohimbine and Rauwolfia (3)
are able to cause strong anxiety, because they are inverse agonists of the GABA receptor
sometimes given to lower blood pressure (4, 5)
Capsazepine (3)
Antagonist; often used in labs to block the TRPV1 receptor (3)
-------------------------------------------------------------------------
TRPA1
Isothiocyanates (Brassica)-(mustard oils) (1,4)
In all kinds of cabbage, cruciferae, horseradisch, wasabi, cress, rape, radish…
Alliin, allicin, plants of the family allium (1,4)
Garlic, onions, leek…
Formaldehyde (2)
Is produced by the incomplete burning of wood, coal, automobile exhaust, tobacco smoke
When reacted with phenol, urea, or melamine formaldehyde produces, respectively, hard thermoset phenol formaldehyde resin, urea formaldehyde resin, and melamine resin, which are commonly used in permanent adhesives such as those used in plywood or carpeting. It is used as the wet-strength resin added to sanitary paper products such as facial tissue, table napkins, and roll towels
Formaldehyde is also a precursor to polyfunctional alcohols such as pentaerythritol, which is used to make paints.
The textile industry uses formaldehyde-based resins as finishers to make fabrics crease-resistant.
An aqueous solution of formaldehyde can be useful as a disinfectant as it kills most bacteria and fungi (including their spores). It is also used as a preservative in vaccines.
4-Hydroxynonenal (2, 8)
Is produced by the body during oxidative stress
Acrolein (1)
Is created:
- if fat from plants or animals is heated over 280 °C or 536 F
- vehicle exhaust
- burning from plants including tobacco
- burning from printer inks, plant oils, organic diesel
- to put out a candle
you can find it in pepperspray, too
is used in the preparation of:
- polyester resin
- polyurethane
- propylene glycol
- acrylic acid
- acrylonitrile
Hydrogen peroxide H2O2 (3)
Use:
- to bleach wood, textiles, paper, oils, fat, hair
- disinfectant and antiseptic
- mild bleaches in laundry detergents
- cleaning wounds, removing dead tissue, oral debriding agent
Cinnamaldehyde (7)
Cinnamon, soaps and fragrances, spices
Lidocain (11)
Local anaesthesia
Bradykinin (1)
TRPA1 is activated by bradykinin in two ways: through PLC-mediated increases in intracellular calcium (or other metabolites) and via calcium influx through TRPV1
---------------------------------------------------------------------------
TRPV3
Carvacrol (1)
265 percent stronger than camphor (1)
Majoram,, pot marjoram, thyme, cumin,
C. can be produced from carvon by storage
Use: disinfectant (4, 5)
Carveol (1)
150 percent stronger than camphor(1)
Cumin, citrus oils (4, 5)
Dihydrocarveol (1)
255 percent stronger than camphor (1)
Cumin, pepper, celeriac, mint (4, 5)
6-Tert-butyl-m-cresol (1)
290 percent stronger than camphor (1)
Found in wood and tobacco smoke, crude oil, coal tar, and in brown mixtures such as creosote, cresolene and cresylic acids, which are wood preservatives, disinfectant, house hold cleaners (Lysol), deodorizers
BHT- Jonol is used as antioxidant and aging inhibitors for plastics, lubricating oils, foods
(4, 5, 6)
Thymol (1)
245 stronger than camphor (1)
Essential oils from thyme, pot marjoram, savory
Use: toothpaste, mouthwash, against fungal infections (4, 5)
Borneol (1)
150 percent stronger than camphor (1)
Valerian, coriander, tansy, sage, nutmeg, rosemary, oak moss, ginger, thyme, lavender and in many other spices (4, 5)
L-Borneol
Aleppo –fir oils, valerian, citronella oil, coriander, white cedar oil (4, 5)
Eugenol (2)
Clove, basil, materials used by the dentist, cinnamon oil (sweet food, curry powder, cosmetic, mouthwash), fragrance in soaps, jasmine oil, bay leaf, nutmeg, myrrh, patchouli oil (fixing agent in fragrances for men, soaps, cosmetic), rose oil, piment essential oil, labdanum (fixing agent for fragrances), cascarilla oil (fragrances in tobacco, and bitter liqueur), bay oil (antiseptics for skin, hair tonic) (4, 5)
Incense (Olibanum) (3)
The resin is found in the bark of Boswellia trees.
Use: fixing agent in perfumes and fragrances
Addition to chewing gum, band-aid, toothpaste
(4, 5)
Substances, which act similar weak on TRPV3 like camphor
Camphor (1)
From camphor trees (Cinnamomum camphora), which are 12 m high laurel tree
Camphor and it derivates can be found in:
Rosemary, lavender, sage, tansy, juniper, valerian, peppermint
Use: celluloid-industry, where it is used as a softener;
Smokeless gunpowder
Against moths
Disinfectant (4, 5)
In the body camphor is changed into borneol
Fenchone (1)
Fennel
Use: perfumes and fragrances, aromatisation of food (4, 5)
Thujone (very weak) (1)
Tansy, sage, wormwood oil (4, 5)
p-Xylenol (1)
Use: starting material for the synthesis of pesticieds, antioxidants and pharmaceuticals (4, 5)
Cresol (1)
Found in wood and tobacco smoke, crude oil, coal tar, and in brown mixtures such as creosote, cresolene and cresylic acids, which are wood preservatives, disinfectant, house hold cleaners (Lysol), deodorizers
BHT- Jonol is used as antioxidant and aging inhibitors for plastics, lubricating oils, foods
(4, 5, 6)
Menthol (1)
Peppermint (4, 5)
Linalool (1)
In many essential oils: coriander, hop, nutmeg, ginger, savory, cinnamon, basil. Majoram, thyme, pot marjoram and other spices (4, 5)
-----------------------------------------------------------------
TRPVs and TRPA1 from article by Pall
This list of substances, which are able to activate some of the TRP receptors, including TRPA1 and some of the TRPV receptor group, is based on the article by Prof Pall and Anderson 2004
Because in that article mainly generic terms are mentioned I added some substances, which we may find in normal life. I marked them with a little star. I took the informations about the area where you can find a substance or its use from the chemist CD Roempp and the wikipedia.
Please keep in your mind that I am a layman.
This list shall help you to find sources, against what you may react. So don’t be scared of the chemical names, pay more attention to the sections about the use and where you can find it.
Sometimes there are substances mentioned, which are used as starting agents or as intermediates. I mentioned them because in an ideal reaction every molecule finds a partner, but in a real reaction not everyone may find a partner and you may breathe it in.
Alcylbenzenes
Name for a group of substances, which have a benzene ring + alcyl groups like methyl.
(toluene, xylenes) or ethylbenzene, mesitylene, tetramethylbenzenes, cymenes (isopropylmethylbenzene)
Benzene
Use: admixture to motor fuels, starting material for the production of benzene derivatives (aniline, nitrobenzene, styrene, nylon, synthetic rubber, plastics, surface active agents in washing powder, phenol, insecticides, dyes…) and as solvent for lacquers, waxes, resins, extraction material
- Toluene –methylbenzene
Is created by the incomplete burning of organic substances like in tobacco smoke and through vehicle exhaust fumes
- Xylene –dimethylbenzene
Use: mainly as solvent. It is used in the production of plastics, dyes, glues and it is added to motor fuels.
- Ethylbenzene*
Use: Ethylbenzene is mainly used in the production of styrene
- Mesitylene –Trimethylbenzene*
Use: solvent for resins and rubber
Can be found in: kerosene and coal tar
- Durene – tetramethylbenzene *
Use: production of heat –resistant resins, polyesters, polyamides, plasticizers, synthetic resins
- Cumene –isopropylbenzene*
Use: Cumene is used in the production of phenols, motor fuels
Cumenesulfonates are used as surface active agents in washing powder
- Cymene –isopropylmethylbezene *
Physiological effects are similar to toluene
It can be found in: essential oils like in caraway and eucalyptus and in many others and it is related structurally to many natural terpenes
Use: solvent, fragrance in cosmetics, synthesis of carvacrol (thyme, marjoram…) and thymol (thyme)
Ethers
It can be found as phenolether in glycosides in alkaloids, flower pigments, fragrances (vanillin)
- Dimethylether *
Use: aerosols in sprays
- Anisole -Methylphenylether*
Use: fragrances
- diphenyl ether *
rose fragrance in soaps and perfumes
Aldehydes
Character: very reactive
Use: lower aldehyds for the production of plastics and synthetic resins, disinfectant, tanning agent
Higher aldehydes in fragrances, aroma, dyes…
- Formaldehyde
Is produced by the incomplete burning of wood, coal, automobile exhaust, tobacco smoke
It can be found in: hard thermoset phenol formaldehyde resin, urea formaldehyde resin, and melamine resin, which are commonly used in permanent adhesives such as those used in plywood or carpeting. It is used as the wet-strength resin added to sanitary paper products such as facial tissue, table napkins, and roll towels
Formaldehyde is also a precursor to polyfunctional alcohols such as pentaerythritol (alkyd resins, softener and emulsifiers)
The textile industry uses formaldehyde-based resins as finishers to make fabrics crease-resistant.
It is also used as a preservative in vaccines and as disinfectant.
- acrolein
is produced, if fat from plants or animals is heated over 280 Celsius or 536 F; burning from plants including tobacco; vehicle exhaust; burning from printer inks, plant oils, organic diesel; if you put out a candle; pepperspray
it is used in the preparation of: polyester resin, polyurethane, propylene glycol, acrylic acid, acrylonitrile
- Acetaldehyde *
Use: Intermediates in the chemical industry
Used in the production of paper, dyes, fragrances- and tanning industry, preservatives for fruits and fish, to make gelatine harder
- Glutaraldehyde *
Use: disinfectant of instruments, to make gelatin harder, tanning agent for leather. It is water resistant and it is used in this way for paper, wallpapers, textiles
- Cinnamaldehyde *
Use: fragrance in soaps, spices, aroma
Can be found in cinnamon
- Benzaldehyde *
synthetic bitter almond oil
Use: cinnamic acid, pharmaceuticals, perfumes, marzipan,
Can be found in plums, hyacinth,
- Glyoxal * (dialdehyde)
Use: textile finishing and in dininfectants
Acids with low ph
Acetic acid (vinegar)
Propionic acid
Solvent for resins; plastics, herbicides
Is produced when organic material is broken down
Sulfur dioxide
Preservation and antioxidant (E220) for food especially dried fruits, potatoes, fruit juices, jam, wine;
To bleach paper and textiles
Toluene diisocyanates TDI
Intermediate during the production of adhesives or glues, foams, polyurethane, lacquers in the automobile industry
Chlorine
Use: bleaching paper and cellulose, to disinfect drinking water and water in swimming pools
Alkanes (methane town gas), ethane, propane)
Halogenated benzenes
Chloroaromatics *
Generic term for chlorination of aromatic compounds like chlorobenzene, chloronaphthalenes, chlorinated biphenyl –PCB …chlorphenole and derivates like 2,3,7,8 Tetrachlordibenzodioxin
Chloroaromatics are often used as intermediates in pharmaceuticals, pesticides, herbicides, disinfectants, preservatives, dyes…
- Chlorobenzene *
Use: solvent for oils, fats, resins, rubbers
Intermediates in the production of insecticides, dyes, pharmaceuticals, fragrances, phenols
- Chloronaphthalenes *
Use: against insects; wood preservatives
- Chlorotoluenes *
Use: solvent and intermediates in the production of dyes, plant protection products
Ketones
Can be found in: essential oils and fragrances, steroids (testosterone), quinones (color in plants and blossoms - when you cut an apple and it turns brown)
Use: starting material for synthetic products in pharma industry; for fragrances, pesticides and ketonic resins
- Ketonic resins *
Use: for lacquers, varnish, printing inks, inks, ball point pen inks
- Cyclohexanone *
Solvent for many lacquers, polyvinylchlorid and cationic dyes, ketonic resins, admixture for paint for leather, special printing inks, remover, intermediates in the production of nylon
Alcohols
Ethanol („normal“ alcohol)
Use: in alcoholic drinks; as solvent in perfumes, cleaning products, pharmaceuticals, disinfectant
Can be found in: ripe banana 1%, apple juice 0,4%. Kefir 1%
Denatoniumbenzoat is added to alcohols, so you won't drink it. You can find it in cleaning products, shampoos, soaps...
Propanols *
Use: disinfectant, solvent
Aliphatic alcohols
Aliphatic – fat or oil
Chloroacetophenone and o-Chlorobenzylidene malononitrile
Use:Pepper spray, tear gas
Molds
“They produce a number of additional unusual organic metabolites (i.e., MVOCs),
including alcohols, terpenes, ketones, aldehydes, esters,
aromatic compounds, amines, and sulfur-containing
compounds. The chemicals produced depend on the
species of mold, the substrate (food) for growth, and the
phase of the life cycle of the mold colony. “(1)
Anthranilates
Term for salts and esters of aminobenzoic acids
Aminobenzoates*
Use: Local anaesthetics (Benzocain, Procain); sun protection products
Anthranilacidmethylester *
smell like orange blossoms and it can be found in the blossoms of Jasmine, neroli, gold varnish, tuberose and leafes of bergamotte and in bitter oranges; used in perfume
Amyl acetate – pentyl acetates
Can be found in the fragrance and aroma of bananas and pears
Author: Namid
www.cababstractsplus.org/google/abstract.asp?AcNo=20053213236
I wanted to try to find out what else is able to activate the TRP -receptors. I depended on the substances, which I found in the literature but I am sure there are much more substances, which can activate them. Please keep in mind that I am a layman.
It is surely not easy to remember all the different substances, therefore here is a little help:
TRPV1 can be activated by things, which are as hot and pungent like chillies, or pepper.
TRPA1 can be activated by pungent things like garlic, onions and mustard oil which you can find in cabbage, radish ...I noticed over the years that several people from the quinolones scene had problems with garlic and similar food. If you have problems with these food, pay attention to the TRPA1.
Alcohol is able to activate TRPV1 in a strong way and it lowers the threshold. So things, which were in former time safe, are it no longer. So please stay away from it!
TRPV1 and TRPA1 are often expressed together. Therefore pay attention to both groups.
TRPV3 can be activated by essential oils in herbs and spices. Pay attention that camphor is changed in the body into borneol, which is 150 times stronger than camphor!
If you notice that herbs or a drug behave in a different way than expected, don’t try it a second time. For example drugs or herbs which should calm down the nervous system may activate TRP receptors and up-regulate this way the nervous system and you may become even more sensitive.
The TRPV receptor is able to release substance P which is causing pain and other substances which are able to create inflammations. Because it can be found in many areas of the body including brain, respiratory tract, digestive systems, skin, heart, bladder, joints … it can play a huge role in pain and inflammations in these areas.
I have written these lists so you have a help to decide, if this receptor family may play a role in your case.
I will try to illustrate it with an example. Imagine having 2 different persons. Person A has a nut allergy. So this person has not only to avoid nuts in general, he has to find out where they may be hidden like in chocolate, cereals… Person B has no nut allergy. Therefore he has not to avoid nuts.
In our cases we have 2 different kinds of people. We all are injured by the quinolones but only some of us may have problems with the TRP receptors and for them these lists may be a help to find out if they react against something and where it is hidden.
If you read the lists, please don’t let yourself discouraged by chemical expressions, which sound complicated. It is more important that you look, if you react more let us say against essential oils and fragrances and where they can be found.
--------------------------------------------------------------------------------
TRPV1
Capsaicin (1, 2)
hot, pungent substance in chilli (4, 5)
RTX – Resiniferatoxin (2)
It is a very strong activator of the TRPV1. You can find it in the resin of plants of the Euphorbia family. Some look like what people may call cactuses, but they are no real cactus. So please look it up in the internet. Poinsettia belongs to this class, too. (4, 5)
Zingeron (3)
Another pungent substance of ginger.
Oil of ginger is used as fixing agent in perfumes (4, 5)
Piperine (3)
pepper (4, 5)
Guaiacol (3)
Resin from Guaiacum officinale (Zygophyllaceae) and it can be found in beech wood tar.
It is used against cough. (4, 5)
Eugenol (3, 9)
It is in:
Clove, basil, materials used by the dentist, cinnamon oil (sweet food, curry powder, cosmetic, mouthwash), fragrance in soaps, jasmine oil, bay leaf, nutmeg, myrrh, patchouli oil (fixing agent in fragrances for men, soaps, cosmetic), rose oil, piment essential oil, labdanum (fixing agent for fragrances), cascarilla oil (fragrances in tobacco, and bitter liqueur), bay oil (antiseptics for skin, hair tonic) (4, 5)
Extract from the roots of Echinacea (6)
(cone flower, black Sampson)
Use: against infections and skin inflammations (4, 5)
Camphor (9)
From camphor trees (Cinnamomum camphora), which are 12 m high laurel tree
Camphor and it derivates can be found in:
Rosemary, lavender, sage, tansy, juniper, valerian, peppermint
Use: celluloid-industry, where it is used as softener;
Smokeless gunpowder, against moths, disinfectant (4, 5)
Cyclohexanone (9)
Solvent for many lacquers, polyvinylchlorid and cationic dyes, ketonic resins, admixture for paint for leather, special printing inks, remover, intermediates in the production of nylon (4, 5)
Ethanol and other alcohols (1, 12)
Propanol: disinfectant, solvent (4, 5)
Lidocain (10)
Local anaesthetic (4, 5)
Evodiamin (3)
Evodia plant is used in chinese medicine (3)
Endogenous substances and other factors
Anandamide (2,3)
Endogenous cannaboide substance (3)
N-arachidonoyldopamine,
Oleoylethanolamide
N-oleoyldopamine (2,3)
Products of the lipoxygenase (2)
Leukotriene B4 (2)
Temperature higher than 43°C – 109F (2)
ph< 5.3 acid (2)
Ginsenosides (3)
Substance from ginseng
can act acitivating and inhibiting
Substances, which inhibit the TRPV1
Thapsigargin (3)
Substance of the plant Thapsia garganica (Apiaceae)
Used against rheumatic pain (3)
Yohimbine and Rauwolfia (3)
are able to cause strong anxiety, because they are inverse agonists of the GABA receptor
sometimes given to lower blood pressure (4, 5)
Capsazepine (3)
Antagonist; often used in labs to block the TRPV1 receptor (3)
-------------------------------------------------------------------------
TRPA1
Isothiocyanates (Brassica)-(mustard oils) (1,4)
In all kinds of cabbage, cruciferae, horseradisch, wasabi, cress, rape, radish…
Alliin, allicin, plants of the family allium (1,4)
Garlic, onions, leek…
Formaldehyde (2)
Is produced by the incomplete burning of wood, coal, automobile exhaust, tobacco smoke
When reacted with phenol, urea, or melamine formaldehyde produces, respectively, hard thermoset phenol formaldehyde resin, urea formaldehyde resin, and melamine resin, which are commonly used in permanent adhesives such as those used in plywood or carpeting. It is used as the wet-strength resin added to sanitary paper products such as facial tissue, table napkins, and roll towels
Formaldehyde is also a precursor to polyfunctional alcohols such as pentaerythritol, which is used to make paints.
The textile industry uses formaldehyde-based resins as finishers to make fabrics crease-resistant.
An aqueous solution of formaldehyde can be useful as a disinfectant as it kills most bacteria and fungi (including their spores). It is also used as a preservative in vaccines.
4-Hydroxynonenal (2, 8)
Is produced by the body during oxidative stress
Acrolein (1)
Is created:
- if fat from plants or animals is heated over 280 °C or 536 F
- vehicle exhaust
- burning from plants including tobacco
- burning from printer inks, plant oils, organic diesel
- to put out a candle
you can find it in pepperspray, too
is used in the preparation of:
- polyester resin
- polyurethane
- propylene glycol
- acrylic acid
- acrylonitrile
Hydrogen peroxide H2O2 (3)
Use:
- to bleach wood, textiles, paper, oils, fat, hair
- disinfectant and antiseptic
- mild bleaches in laundry detergents
- cleaning wounds, removing dead tissue, oral debriding agent
Cinnamaldehyde (7)
Cinnamon, soaps and fragrances, spices
Lidocain (11)
Local anaesthesia
Bradykinin (1)
TRPA1 is activated by bradykinin in two ways: through PLC-mediated increases in intracellular calcium (or other metabolites) and via calcium influx through TRPV1
---------------------------------------------------------------------------
TRPV3
Carvacrol (1)
265 percent stronger than camphor (1)
Majoram,, pot marjoram, thyme, cumin,
C. can be produced from carvon by storage
Use: disinfectant (4, 5)
Carveol (1)
150 percent stronger than camphor(1)
Cumin, citrus oils (4, 5)
Dihydrocarveol (1)
255 percent stronger than camphor (1)
Cumin, pepper, celeriac, mint (4, 5)
6-Tert-butyl-m-cresol (1)
290 percent stronger than camphor (1)
Found in wood and tobacco smoke, crude oil, coal tar, and in brown mixtures such as creosote, cresolene and cresylic acids, which are wood preservatives, disinfectant, house hold cleaners (Lysol), deodorizers
BHT- Jonol is used as antioxidant and aging inhibitors for plastics, lubricating oils, foods
(4, 5, 6)
Thymol (1)
245 stronger than camphor (1)
Essential oils from thyme, pot marjoram, savory
Use: toothpaste, mouthwash, against fungal infections (4, 5)
Borneol (1)
150 percent stronger than camphor (1)
Valerian, coriander, tansy, sage, nutmeg, rosemary, oak moss, ginger, thyme, lavender and in many other spices (4, 5)
L-Borneol
Aleppo –fir oils, valerian, citronella oil, coriander, white cedar oil (4, 5)
Eugenol (2)
Clove, basil, materials used by the dentist, cinnamon oil (sweet food, curry powder, cosmetic, mouthwash), fragrance in soaps, jasmine oil, bay leaf, nutmeg, myrrh, patchouli oil (fixing agent in fragrances for men, soaps, cosmetic), rose oil, piment essential oil, labdanum (fixing agent for fragrances), cascarilla oil (fragrances in tobacco, and bitter liqueur), bay oil (antiseptics for skin, hair tonic) (4, 5)
Incense (Olibanum) (3)
The resin is found in the bark of Boswellia trees.
Use: fixing agent in perfumes and fragrances
Addition to chewing gum, band-aid, toothpaste
(4, 5)
Substances, which act similar weak on TRPV3 like camphor
Camphor (1)
From camphor trees (Cinnamomum camphora), which are 12 m high laurel tree
Camphor and it derivates can be found in:
Rosemary, lavender, sage, tansy, juniper, valerian, peppermint
Use: celluloid-industry, where it is used as a softener;
Smokeless gunpowder
Against moths
Disinfectant (4, 5)
In the body camphor is changed into borneol
Fenchone (1)
Fennel
Use: perfumes and fragrances, aromatisation of food (4, 5)
Thujone (very weak) (1)
Tansy, sage, wormwood oil (4, 5)
p-Xylenol (1)
Use: starting material for the synthesis of pesticieds, antioxidants and pharmaceuticals (4, 5)
Cresol (1)
Found in wood and tobacco smoke, crude oil, coal tar, and in brown mixtures such as creosote, cresolene and cresylic acids, which are wood preservatives, disinfectant, house hold cleaners (Lysol), deodorizers
BHT- Jonol is used as antioxidant and aging inhibitors for plastics, lubricating oils, foods
(4, 5, 6)
Menthol (1)
Peppermint (4, 5)
Linalool (1)
In many essential oils: coriander, hop, nutmeg, ginger, savory, cinnamon, basil. Majoram, thyme, pot marjoram and other spices (4, 5)
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TRPVs and TRPA1 from article by Pall
This list of substances, which are able to activate some of the TRP receptors, including TRPA1 and some of the TRPV receptor group, is based on the article by Prof Pall and Anderson 2004
Because in that article mainly generic terms are mentioned I added some substances, which we may find in normal life. I marked them with a little star. I took the informations about the area where you can find a substance or its use from the chemist CD Roempp and the wikipedia.
Please keep in your mind that I am a layman.
This list shall help you to find sources, against what you may react. So don’t be scared of the chemical names, pay more attention to the sections about the use and where you can find it.
Sometimes there are substances mentioned, which are used as starting agents or as intermediates. I mentioned them because in an ideal reaction every molecule finds a partner, but in a real reaction not everyone may find a partner and you may breathe it in.
Alcylbenzenes
Name for a group of substances, which have a benzene ring + alcyl groups like methyl.
(toluene, xylenes) or ethylbenzene, mesitylene, tetramethylbenzenes, cymenes (isopropylmethylbenzene)
Benzene
Use: admixture to motor fuels, starting material for the production of benzene derivatives (aniline, nitrobenzene, styrene, nylon, synthetic rubber, plastics, surface active agents in washing powder, phenol, insecticides, dyes…) and as solvent for lacquers, waxes, resins, extraction material
- Toluene –methylbenzene
Is created by the incomplete burning of organic substances like in tobacco smoke and through vehicle exhaust fumes
- Xylene –dimethylbenzene
Use: mainly as solvent. It is used in the production of plastics, dyes, glues and it is added to motor fuels.
- Ethylbenzene*
Use: Ethylbenzene is mainly used in the production of styrene
- Mesitylene –Trimethylbenzene*
Use: solvent for resins and rubber
Can be found in: kerosene and coal tar
- Durene – tetramethylbenzene *
Use: production of heat –resistant resins, polyesters, polyamides, plasticizers, synthetic resins
- Cumene –isopropylbenzene*
Use: Cumene is used in the production of phenols, motor fuels
Cumenesulfonates are used as surface active agents in washing powder
- Cymene –isopropylmethylbezene *
Physiological effects are similar to toluene
It can be found in: essential oils like in caraway and eucalyptus and in many others and it is related structurally to many natural terpenes
Use: solvent, fragrance in cosmetics, synthesis of carvacrol (thyme, marjoram…) and thymol (thyme)
Ethers
It can be found as phenolether in glycosides in alkaloids, flower pigments, fragrances (vanillin)
- Dimethylether *
Use: aerosols in sprays
- Anisole -Methylphenylether*
Use: fragrances
- diphenyl ether *
rose fragrance in soaps and perfumes
Aldehydes
Character: very reactive
Use: lower aldehyds for the production of plastics and synthetic resins, disinfectant, tanning agent
Higher aldehydes in fragrances, aroma, dyes…
- Formaldehyde
Is produced by the incomplete burning of wood, coal, automobile exhaust, tobacco smoke
It can be found in: hard thermoset phenol formaldehyde resin, urea formaldehyde resin, and melamine resin, which are commonly used in permanent adhesives such as those used in plywood or carpeting. It is used as the wet-strength resin added to sanitary paper products such as facial tissue, table napkins, and roll towels
Formaldehyde is also a precursor to polyfunctional alcohols such as pentaerythritol (alkyd resins, softener and emulsifiers)
The textile industry uses formaldehyde-based resins as finishers to make fabrics crease-resistant.
It is also used as a preservative in vaccines and as disinfectant.
- acrolein
is produced, if fat from plants or animals is heated over 280 Celsius or 536 F; burning from plants including tobacco; vehicle exhaust; burning from printer inks, plant oils, organic diesel; if you put out a candle; pepperspray
it is used in the preparation of: polyester resin, polyurethane, propylene glycol, acrylic acid, acrylonitrile
- Acetaldehyde *
Use: Intermediates in the chemical industry
Used in the production of paper, dyes, fragrances- and tanning industry, preservatives for fruits and fish, to make gelatine harder
- Glutaraldehyde *
Use: disinfectant of instruments, to make gelatin harder, tanning agent for leather. It is water resistant and it is used in this way for paper, wallpapers, textiles
- Cinnamaldehyde *
Use: fragrance in soaps, spices, aroma
Can be found in cinnamon
- Benzaldehyde *
synthetic bitter almond oil
Use: cinnamic acid, pharmaceuticals, perfumes, marzipan,
Can be found in plums, hyacinth,
- Glyoxal * (dialdehyde)
Use: textile finishing and in dininfectants
Acids with low ph
Acetic acid (vinegar)
Propionic acid
Solvent for resins; plastics, herbicides
Is produced when organic material is broken down
Sulfur dioxide
Preservation and antioxidant (E220) for food especially dried fruits, potatoes, fruit juices, jam, wine;
To bleach paper and textiles
Toluene diisocyanates TDI
Intermediate during the production of adhesives or glues, foams, polyurethane, lacquers in the automobile industry
Chlorine
Use: bleaching paper and cellulose, to disinfect drinking water and water in swimming pools
Alkanes (methane town gas), ethane, propane)
Halogenated benzenes
Chloroaromatics *
Generic term for chlorination of aromatic compounds like chlorobenzene, chloronaphthalenes, chlorinated biphenyl –PCB …chlorphenole and derivates like 2,3,7,8 Tetrachlordibenzodioxin
Chloroaromatics are often used as intermediates in pharmaceuticals, pesticides, herbicides, disinfectants, preservatives, dyes…
- Chlorobenzene *
Use: solvent for oils, fats, resins, rubbers
Intermediates in the production of insecticides, dyes, pharmaceuticals, fragrances, phenols
- Chloronaphthalenes *
Use: against insects; wood preservatives
- Chlorotoluenes *
Use: solvent and intermediates in the production of dyes, plant protection products
Ketones
Can be found in: essential oils and fragrances, steroids (testosterone), quinones (color in plants and blossoms - when you cut an apple and it turns brown)
Use: starting material for synthetic products in pharma industry; for fragrances, pesticides and ketonic resins
- Ketonic resins *
Use: for lacquers, varnish, printing inks, inks, ball point pen inks
- Cyclohexanone *
Solvent for many lacquers, polyvinylchlorid and cationic dyes, ketonic resins, admixture for paint for leather, special printing inks, remover, intermediates in the production of nylon
Alcohols
Ethanol („normal“ alcohol)
Use: in alcoholic drinks; as solvent in perfumes, cleaning products, pharmaceuticals, disinfectant
Can be found in: ripe banana 1%, apple juice 0,4%. Kefir 1%
Denatoniumbenzoat is added to alcohols, so you won't drink it. You can find it in cleaning products, shampoos, soaps...
Propanols *
Use: disinfectant, solvent
Aliphatic alcohols
Aliphatic – fat or oil
Chloroacetophenone and o-Chlorobenzylidene malononitrile
Use:Pepper spray, tear gas
Molds
“They produce a number of additional unusual organic metabolites (i.e., MVOCs),
including alcohols, terpenes, ketones, aldehydes, esters,
aromatic compounds, amines, and sulfur-containing
compounds. The chemicals produced depend on the
species of mold, the substrate (food) for growth, and the
phase of the life cycle of the mold colony. “(1)
Anthranilates
Term for salts and esters of aminobenzoic acids
Aminobenzoates*
Use: Local anaesthetics (Benzocain, Procain); sun protection products
Anthranilacidmethylester *
smell like orange blossoms and it can be found in the blossoms of Jasmine, neroli, gold varnish, tuberose and leafes of bergamotte and in bitter oranges; used in perfume
Amyl acetate – pentyl acetates
Can be found in the fragrance and aroma of bananas and pears
Author: Namid