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Post by myrnawearshats on May 2, 2011 15:35:28 GMT -5
Has anyone found this helpful for their nerve pain?
I had a paradoxical reaction to it. I felt absolutely wired and both my nerve pain and muscle spasms increased like wild.
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Post by freudianfloxed on May 3, 2011 10:45:44 GMT -5
I had a ugly reaction to Neurontin (Gabapentin) a couple of years ago. I took one 300 mg dose at the urging of a doctor and had to go to the E.R. I got severe flu like symptoms, severe chills (no fever), burning nerve pain all over..., misc other stuff. The doctor was amazed and said "that's unusual", when I looked up the side effects in the PDA they were all there and it seem liked I got them all. That whole episode got me researching damage to our enzymatic (CYP) pathways, which I believe many floxies have.
Today, I would have never started with that high of a dose but at the time I was still very ignorant to that damages that I had received. For myself, I have CYP pathway inhibition, which I did not know at the time, and is extremely critical to know for the metabolism of medication. It is a reason why many floxies are sensitive to medication. Pathway inhibition causes medicine to build up to much higher serum levels, so that one 300 mg dose of gabapentin was probably similar to single 600 mg dose or higher to my body. In the future if I ever have to try gabapentin again I would start at a very low dose probably 75 mg or so. Anyway, some folks say they take it with no problems whatsoever, but as I always say, if you must, 'low and slow', be cautious.
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Post by myrnawearshats on May 4, 2011 16:45:32 GMT -5
freudianfloxed, how do we reverse enzymatic pathway inhibition?
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Deleted
Deleted Member
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Post by Deleted on May 4, 2011 23:22:10 GMT -5
Freudianfloxed, which CYPs are in your case genetically inhibit? In my case it is CYP2D6 and CYP1A2 is "changed" (I am writing this from memory- it was not clear when the change happened) In addition GST M1 and GSTP1 are not working. At the old forum there had been several persons, which had genetic changes at CYP2C9 and CYP2C19 (if they are not working, you may had in the past problems with coffee and ibuprofen). myrnawearshats, you can find more informations about it at health-quest.proboards.com/index.cgi?board=environmental&action=display&thread=26I would only do such tests, if you and other persons in your family had problems with drugs/chemicals in the past, because these tests are expensive. I am more concerned about the fact that nitric oxide is able to inhibit this enzyme family. This may explain why people who are badly injured and have high sensitivities have to struggle with not working CYPs doesn't matter how good these enzymes are from the genetic point of view.
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Post by myrnawearshats on May 5, 2011 6:27:07 GMT -5
It's now pissing me off that it's been left to us to do the research and make hypotheses which should be done by real scientists. Funded by the makers of these poisons.
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Post by beebs on May 5, 2011 9:43:22 GMT -5
It's now pissing me off that it's been left to us to do the research and make hypotheses which should be done by real scientists. Funded by the makers of these poisons. Ironic how little they understand about the human body, lol, Good at messing it up, iatrogenic, environmental crap, Fixing the body, they can't, and that is precisely because they don't know how it works to begin with... In all those years, I've seen many "experts", if questioned or challenged, the honest ones, say they don't know, the arrogant with large egos make up some stupid psychobabble, which sounds even more fluffy, ;D or say we don't want to get well. The rest is up to us, dig out info/share to prevent more harm!
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Post by myrnawearshats on May 15, 2011 17:54:54 GMT -5
What annoys me most is the attitude of ignoring the obvious and following wasteful systems, the denial of oh ok this person has all the side effects listed as possibilities from this drug but lets run thousands of dollars of tests to rule out things it obviously isn't.
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