Post by Admin on Apr 18, 2011 8:48:59 GMT -5
Facts and FAQS (Will be updated to answer the most common questions concerning toxicity symptoms)
Draft
See below articles re: medications and its affect at cellular level. A large percentage of ME/CFS, Gulf War Vets, Fibromyalgia sufferers fell ill exhibiting multiple symptoms following an infection. Some were given antibiotics - rarely make a connection between antibiotics (or other meds) and their symptoms. Roaccutane (for acne) is a typical example of prolonged symptoms over a period of years, as well as corticosteroids, and other prescribed meds.
Advised to see those videos (and Abstracts below) explaining the mechanism of toxicities in simple layman's terms:
www.factsontoxicity.com/index1.php
Adverse reactions can be immediate or delayed - symptoms lingering over a period of many years. Primary/secondary symptoms can appear within days, sometimes delayed, appearing even two years later or more.
According to research, all antibiotics and most meds cause toxicities at mitochondrial level, thereafter, manifesting in various chronic disease states.
The link will take you to a site, posts of patients dying and others complaining of horrific symptoms from antibiotics: www.patientsville.com/medication/antibiotics_side_effects.htm
Medication-induced mitochondrial damage and disease.
Journal: Mol Nutr Food Res. 2008 Jul 14;52(7):780-788. [Epub ahead of print]
Authors: Neustadt J, Pieczenik SR.
Affiliation: Montana Integrative Medicine, Bozeman, MT, USA. Fax: +1-866-648-7579.
NLM Citation: PMID: 18626887
Since the first mitochondrial dysfunction was described in the 1960s, the medicine has advanced in its understanding the role mitochondria play in health and disease. Damage to mitochondria is now understood to play a role in the pathogenesis of a wide range of seemingly unrelated disorders such as schizophrenia, bipolar disease, dementia, Alzheimer’s disease, epilepsy, migraine headaches, strokes, neuropathic pain, Parkinson’s disease, ataxia, transient ischemic attack, cardiomyopathy, coronary artery disease, chronic fatigue syndrome, fibromyalgia, retinitis pigmentosa, diabetes, hepatitis C, and primary biliary cirrhosis.
Medications have now emerged as a major cause of mitochondrial damage, which may explain many adverse effects. All classes of psychotropic drugs have been documented to damage mitochondria, as have statin medications, analgesics such as acetaminophen, and many others. tinyurl.com/6zrervn
As a side note, antibiotics are known to cause damage to mitochondria as mentioned in other published papers. Antibiotics sticks to the DNA adducts causing cycling symptoms over many years and ensuing health issues
Pharmacologic effects on mitochondrial function.
Cohen BH.
Cleveland Clinic Lerner College of Medicine, Case Western Reserve University, 9500 Euclid Avenue, Cleveland, OH 44195, USA. cohenb2@ccf.org
Abstract
The vast majority of energy necessary for cellular function is produced in mitochondria. Free-radical production and apoptosis are other critical mitochondrial functions. The complex structure, electrochemical properties of the inner mitochondrial membrane (IMM), and genetic control from both mitochondrial DNA (mtDNA) and nuclear DNA (nDNA) are some of the unique features that explain why the mitochondria are vulnerable to environmental injury. Because of similarity to bacterial translational machinery, mtDNA translation is likewise vulnerable to inhibition by some antibiotics. The mechanism of mtDNA replication, which is required for normal mitochondrial maintenance and duplication, is inhibited by a relatively new class of drugs used to treat AIDS. The electrochemical gradient maintained by the IMM is vulnerable to many drugs that are weak organic acids at physiological pH, resulting in excessive free-radical generation and uncoupling of oxidative phosphorylation. Many of these drugs can cause clinical injury in otherwise healthy people, but there are also examples where particular gene mutations may predispose to increased drug toxicity. The spectrum of drug-induced mitochondrial dysfunction extends across many drug classes. It is hoped that preclinical pharmacogenetic and functional studies of mitochondrial toxicity, along with personalized genomic medicine, will improve both our understanding of mitochondrial drug toxicity and patient safety.
Influence on Mitochondria and Cytotoxicity of
Different Antibiotics in High Concentrations on
Primary Human Osteoblasts and Cell Lines
aac.asm.org/cgi/reprint/AAC.00729-05v1.pdf
Am J Physiol Cell Physiol 293: C12-C21, 2007. First published May 2, 2007;
SPECIAL SECTION ON MITOCHONDRIAL MODELING AND FUNCTION
ajpcell.physiology.org/content/293/1/C12.full
There are hundreds of articles on PubMed concerning the effects of
medications on mitochondria. Some can be found here with
comments: tinyurl.com/6hwfk4k
Drug Metabolism:
Nuclear Receptors and the Regulation of Drug-Metabolizing Enzymes and Drug Transporters: Implications for Interindividual Variability in Response to Drugs
1. Bradley L. Urquhart, PhD
2. Rommel G. Tirona, PhD
3. Richard B. Kim, MD
From the Division of Clinical Pharmacology, Department of Medicine (Dr Urquhart, Dr Tirona, Dr Kim), and the Department of Physiology & Pharmacology (Dr Tirona), University of Western Ontario, London, Ontario, Canada.
Abstract
Erratic or unpredictable response to drugs remains a challenge of modern drug therapy. An important determinant of such interindividual differences in drug response is variability in the expression of drug-metabolizing enzymes and/or transporters at sites of absorption and/or tissue distribution. Variable drug-metabolizing enzyme and transporter expression can result in unpredictable exposure and tissue distribution of drugs and may manifest as adverse effects or therapeutic failure. Cont/....tinyurl.com/6hwfk4k
The paper below concerns depression of the Immune System post antibiotics. The paper discusses the reactivation of EBV (mono), CMV and HHV-6 infectious pathogens. It may explain why many of us suffer from chronic infections, whilst others were found to have Lyme Disease and more.
Adverse antibiotic-induced eruptions associated with epstein barr virus infection and showing Kikuchi-Fujimoto disease-like histology.
Carlson JA, Perlmutter A, Tobin E, Richardson D, Rohwedder A.
Division of Dermatology, Department of Pathology, Albany Medical College, Albany, New York 12208, USA. carlsoa@mail.amc.edu
The antibiotic-induced eruption of infectious mononucleosis is a well-known clinical phenomenon. Latent viral infection with herpesviridae (eg, human herpes virus 6 (HHV-6) and Epstein-Barr virus (EBV)) is suspected to play a role in the drug hypersensitivity syndrome. tinyurl.com/6hwfk4k
Aside the well known side effects of FQs, other antibiotics also cause damage to tendons, CNS symptoms and so forth.
"adverse effects for various fluoroquinolones was 3-40%. By comparison, these same studies reported adverse event rates of 2-49% for trimethoprim-sulfamethoxazole, 6-35% for penicillins, 12-39% for cephalosporins, 19-23% for doxycycline, and approximately 39% for erythromycin.[10,11]" www.medscape.com/viewarticle/418295
A word of caution. Before taking medications, read up the pharmacological compounds, side effects, ADRs and read about other patients's experience on other sites.
Draft
See below articles re: medications and its affect at cellular level. A large percentage of ME/CFS, Gulf War Vets, Fibromyalgia sufferers fell ill exhibiting multiple symptoms following an infection. Some were given antibiotics - rarely make a connection between antibiotics (or other meds) and their symptoms. Roaccutane (for acne) is a typical example of prolonged symptoms over a period of years, as well as corticosteroids, and other prescribed meds.
Advised to see those videos (and Abstracts below) explaining the mechanism of toxicities in simple layman's terms:
www.factsontoxicity.com/index1.php
Adverse reactions can be immediate or delayed - symptoms lingering over a period of many years. Primary/secondary symptoms can appear within days, sometimes delayed, appearing even two years later or more.
According to research, all antibiotics and most meds cause toxicities at mitochondrial level, thereafter, manifesting in various chronic disease states.
The link will take you to a site, posts of patients dying and others complaining of horrific symptoms from antibiotics: www.patientsville.com/medication/antibiotics_side_effects.htm
Medication-induced mitochondrial damage and disease.
Journal: Mol Nutr Food Res. 2008 Jul 14;52(7):780-788. [Epub ahead of print]
Authors: Neustadt J, Pieczenik SR.
Affiliation: Montana Integrative Medicine, Bozeman, MT, USA. Fax: +1-866-648-7579.
NLM Citation: PMID: 18626887
Since the first mitochondrial dysfunction was described in the 1960s, the medicine has advanced in its understanding the role mitochondria play in health and disease. Damage to mitochondria is now understood to play a role in the pathogenesis of a wide range of seemingly unrelated disorders such as schizophrenia, bipolar disease, dementia, Alzheimer’s disease, epilepsy, migraine headaches, strokes, neuropathic pain, Parkinson’s disease, ataxia, transient ischemic attack, cardiomyopathy, coronary artery disease, chronic fatigue syndrome, fibromyalgia, retinitis pigmentosa, diabetes, hepatitis C, and primary biliary cirrhosis.
Medications have now emerged as a major cause of mitochondrial damage, which may explain many adverse effects. All classes of psychotropic drugs have been documented to damage mitochondria, as have statin medications, analgesics such as acetaminophen, and many others. tinyurl.com/6zrervn
As a side note, antibiotics are known to cause damage to mitochondria as mentioned in other published papers. Antibiotics sticks to the DNA adducts causing cycling symptoms over many years and ensuing health issues
Pharmacologic effects on mitochondrial function.
Cohen BH.
Cleveland Clinic Lerner College of Medicine, Case Western Reserve University, 9500 Euclid Avenue, Cleveland, OH 44195, USA. cohenb2@ccf.org
Abstract
The vast majority of energy necessary for cellular function is produced in mitochondria. Free-radical production and apoptosis are other critical mitochondrial functions. The complex structure, electrochemical properties of the inner mitochondrial membrane (IMM), and genetic control from both mitochondrial DNA (mtDNA) and nuclear DNA (nDNA) are some of the unique features that explain why the mitochondria are vulnerable to environmental injury. Because of similarity to bacterial translational machinery, mtDNA translation is likewise vulnerable to inhibition by some antibiotics. The mechanism of mtDNA replication, which is required for normal mitochondrial maintenance and duplication, is inhibited by a relatively new class of drugs used to treat AIDS. The electrochemical gradient maintained by the IMM is vulnerable to many drugs that are weak organic acids at physiological pH, resulting in excessive free-radical generation and uncoupling of oxidative phosphorylation. Many of these drugs can cause clinical injury in otherwise healthy people, but there are also examples where particular gene mutations may predispose to increased drug toxicity. The spectrum of drug-induced mitochondrial dysfunction extends across many drug classes. It is hoped that preclinical pharmacogenetic and functional studies of mitochondrial toxicity, along with personalized genomic medicine, will improve both our understanding of mitochondrial drug toxicity and patient safety.
Influence on Mitochondria and Cytotoxicity of
Different Antibiotics in High Concentrations on
Primary Human Osteoblasts and Cell Lines
aac.asm.org/cgi/reprint/AAC.00729-05v1.pdf
Am J Physiol Cell Physiol 293: C12-C21, 2007. First published May 2, 2007;
SPECIAL SECTION ON MITOCHONDRIAL MODELING AND FUNCTION
ajpcell.physiology.org/content/293/1/C12.full
There are hundreds of articles on PubMed concerning the effects of
medications on mitochondria. Some can be found here with
comments: tinyurl.com/6hwfk4k
Drug Metabolism:
Nuclear Receptors and the Regulation of Drug-Metabolizing Enzymes and Drug Transporters: Implications for Interindividual Variability in Response to Drugs
1. Bradley L. Urquhart, PhD
2. Rommel G. Tirona, PhD
3. Richard B. Kim, MD
From the Division of Clinical Pharmacology, Department of Medicine (Dr Urquhart, Dr Tirona, Dr Kim), and the Department of Physiology & Pharmacology (Dr Tirona), University of Western Ontario, London, Ontario, Canada.
Abstract
Erratic or unpredictable response to drugs remains a challenge of modern drug therapy. An important determinant of such interindividual differences in drug response is variability in the expression of drug-metabolizing enzymes and/or transporters at sites of absorption and/or tissue distribution. Variable drug-metabolizing enzyme and transporter expression can result in unpredictable exposure and tissue distribution of drugs and may manifest as adverse effects or therapeutic failure. Cont/....tinyurl.com/6hwfk4k
The paper below concerns depression of the Immune System post antibiotics. The paper discusses the reactivation of EBV (mono), CMV and HHV-6 infectious pathogens. It may explain why many of us suffer from chronic infections, whilst others were found to have Lyme Disease and more.
Adverse antibiotic-induced eruptions associated with epstein barr virus infection and showing Kikuchi-Fujimoto disease-like histology.
Carlson JA, Perlmutter A, Tobin E, Richardson D, Rohwedder A.
Division of Dermatology, Department of Pathology, Albany Medical College, Albany, New York 12208, USA. carlsoa@mail.amc.edu
The antibiotic-induced eruption of infectious mononucleosis is a well-known clinical phenomenon. Latent viral infection with herpesviridae (eg, human herpes virus 6 (HHV-6) and Epstein-Barr virus (EBV)) is suspected to play a role in the drug hypersensitivity syndrome. tinyurl.com/6hwfk4k
Aside the well known side effects of FQs, other antibiotics also cause damage to tendons, CNS symptoms and so forth.
"adverse effects for various fluoroquinolones was 3-40%. By comparison, these same studies reported adverse event rates of 2-49% for trimethoprim-sulfamethoxazole, 6-35% for penicillins, 12-39% for cephalosporins, 19-23% for doxycycline, and approximately 39% for erythromycin.[10,11]" www.medscape.com/viewarticle/418295
A word of caution. Before taking medications, read up the pharmacological compounds, side effects, ADRs and read about other patients's experience on other sites.