Post by Deleted on Apr 25, 2011 23:40:09 GMT -5
Use of these informations:
These shall help you to find out, if these 2 enzymes are in your case working
or not. In the literature is often mentioned that the quinolones inhibit 1A2
and 3A4. The question is for how long. In normal persons it should be only for
a short time. In my case it seems that there is an inhibition over many years
now.
So for example if you react against caffeine, anise, dill, fennel, smell of
chemicals, perfumes , it is likely that 1A2 does not work and you should avoid
other substances , which are broken down by this enzyme.
------------------------------------------------------------------------------
---------------
Wikipedia - Cyp450
en.wikipedia.org/wiki/Cyp450
Cytochrome P450 oxidase (commonly abbreviated CYP) is a generic term for a
large number of related, but distinct, oxidative enzymes (EC 1.14) important in
animal physiology. The cytochrome P450 mixed-function monooxygenase system is
probably the most important element of Phase I metabolism in animals
(metabolism in this context being the chemical modification or degradation of
chemicals
including drugs and endogenous compounds)
P450s are membrane-associated proteins, either in the inner membrane of
mitochondria or in the endoplasmic reticulum of cells where they metabolise
thousands of endogenous and exogenous compounds. In the liver, these substrates
include drugs and toxic compounds as well as metabolic products such as
bilirubin
(a breakdown product of hemoglobin). Cytochromes P450 are present in many other
tissues of the body including the mucosa of the gastrointestinal tract, and
play important roles in hormone synthesis and breakdown (including estrogen and
testosterone synthesis and metabolism), cholesterol synthesis, and vitamin D
metabolism. In most animals, including humans, hepatic cytochromes P450 are
the most widely studied of the P450 enzymes.
------------------------------------------------------------------------------
-----------
1A2
substrates
cineole - eucalyptol;
coumarin - blossoms and leaves,lavender oil, gras and clover,
skatol - rotting of proteins,faeces
aflotoxin (toxin from mold)
xantine-caffeine (coffee, tea, chocolate )
pesticides
alcohol
genistein -flavonoid, soybeans
nicotin
naphthalen-moth control, tanning agents, colors
piperazine-can be in gums/plastic
phenylphenol-it is put on the skin of bananas and citrus fruits
organic solvents
marijuana
linoleic acid - fatty acid
melatonin
arachidonic acid
estrogen
phosphatidylcholine-phospholipid
progesteron
uroporphyrinogen-Porphyria
diclofenac
Paracetamol;
Acetanilide (used as test/marker substrate);
NSAID;
cinnarizine-antihistamines/ piperazine;
Diphenhydramine- antihistamines;
benzodiazepine - Anxiolytic, sedative,
Fluoxetine- Selective serotonin reuptake inhibitor, SSRI(antidepressant)
;Lidocain-Local anesthetic;
tetracyclic antidepressants;
Propofol-General anesthetic;
Inhibitor:
Hop (Chalcone);
Hydroxystilbene deriv.- Herbal const -used in some colors,fungicide,rhubarb;
Naringenin, potent inhibitor( is what makes grapefruit taste bitter);
Bergamottin- Grapefruit juice subst -used in Earl Grey Tea and in hair oil.,
Adrenaline;
Apiaceous vegetables like: anise, dill, fennel, caraway, carrot, parsley,
celeriac;
Apigenin (potent inhibitor)- Grapefruit juice subst., celery, parsley,
blossoms of Chrysanthenum;
Coumarin- smell of fresh cut grass or if it fades (smell of hey); is in
Apiaceae, too
Chrysin (potent inhibitor), blossoms of poplar, "Coniferen, Fagales, Rosales,
Bignoniaceae"(does anyone know what kind of plants they are?.
Epicatechin- Catechin, Green tea comp -recognizable at the brown parts on
apples potatoes, when they got pressure or were cut
Galangin; - galanga - a kind of ginger
Genistein - soybeans;
Indole 3-acetaldehyde - neurotransmitter;
Interleukin (IL)-2 (at high conc.);
Lidocain- local anesthetic;
methanol;
phenol-olive oil component, pine wood and needle, tar...;
parathion - pesticide;
Isothiocyanate, Cruciferous vegetables const.;
Contain mustard seed oil: all cabbage, rape, turnip, radish, horseradish,
caper, cress, mustard, wall flower
propofol - General anesthetic;
Protein deficiency;
Quercetin- Grapefruit juice, strawberry etc. subst., in the bark of trees
(oak) +shells and skin of many fruits and vegetables + their leaves, onions,
camomile, hop, whitethorn, appletree, roses, cress, St John's Wort
Rhaponticin- Herbal const., trans-Hydroxystilbene deriv. - rhubarb
Serotonin;( is very much in bananas and pineapple)
Tangeretin- Orange;
Phytoalexin (in red wine, grape, peanuts), trans-Hydroxystilbene;
Phytoalexine -substances, which plants produce to defend themselves against
fungus
-which may be important in our case: capsidicin (makes pepper hot);wyeron
-horse-beans
Tryptamine-neurotransmitter;
--------------------
en.wikipedia.org/wiki/CYP1A2
1A2 substrates
amitriptyline, caffeine, clomipramine, clozapine, cyclobenzaprine, estradiol,
fluvoxamine, haloperidol, imipramine, mexiletine, naproxen, olanzapine,
ondansetron, paracetamol, propranolol, riluzole, ropivacaine, tacrine,
theophylline, tizanidine, verapamil, warfarin, zileuton, zolmitriptan
1A2 inhibitors
amiodarone, cimetidine, fluoroquinolones (ciprofloxacin, etc), fluvoxamine,
interferon, methoxsalen
-----------------------
medicine.iupui.edu/flockhart/table.htm
1A2 Substrates:
amitriptyline,caffeine,clomipramine,clozapine,cyclobenzaprine,estradiol,
fluvoxamine,haloperidol,imipramine,N-DeMe,mexilletine,naproxen,olanzapine,
ondansetron, phenacetin, acetaminophen,
propranolol,riluzole,ropivacaine,tacrine,theophylline,tizanidine,verapamil,
(R)warfarin,zileuton,zolmitriptan
1A2 inhibtors
amiodarone,cimetidine,ciprofloxacin,fluoroquinolones,fluvoxamine,
furafylline,interferon,methoxsalen,mibefradil,
-----------------------------------------------------------------------------
medicine.iupui.edu/flockhart/table.htm
3A4
substrates
Macrolide antibiotics:clarithromycin,erythromycin, NOT azithromycin,
telithromycin,
Anti-arrhythmics:quinidine
Benzodiazepines:alprazolam,diazepam, midazolam, triazolam
Immune Modulators:cyclosporine,tacrolimus (FK506)
Prokinetic:
cisapride
Antihistamines:
astemizole, chlorpheniramine, terfenidine
Calcium Channel Blockers:
amlodipine,diltiazem,felodipine,lercanidipine,nifedipine,nisoldipine,
nitrendipine,verapamil
HMG CoA Reductase Inhibitors:
atorvastatin,cerivastatin,lovastatin,NOT pravastatin,simvastatin,
Steroid 6beta-OH:
estradiol,hydrocortisone,progesterone,testosterone
Miscellaneous:
alfentanyl,aprepitant,aripiprazole,buspirone,cafergot,caffeine,
cilostazol,cocaine,codeine- N-demethylation,
dapsone,dextromethorphan,docetaxel,domperidone,eplerenone,
fentanyl,finasteride,gleevec,haloperidol,irinotecan,LAAM,lidocaine,
methadone,nateglinide,odanestron,pimozide,propranolol,quetiapine,
quinine,NOT rosuvastatin,salmeterol,sildenafil,sirolimus,tamoxifen,
taxol,terfenadine,trazodone,vincristine,zaleplon,zolpidem,
3A4 inhibitors
amiodarone,aprepitant,NOTazithromycin,chloramphenicol,cimetidine,
clarithromycin,diethyl-dithiocarbamate,
diltiazem,erythromycin,fluconazole,fluvoxamine,gestodene,
grapefruit juice,imatinib,itraconazole,ketoconazole,mifepristone,
nefazodone,norfloxacin,norfluoxetine,mibefradil,star fruit,
verapamil,voriconazole
en.wikipedia.org/wiki/CYP3A4
3A4 substrates
amiodarone, azole antifungals (ketoconazole etc), barbiturates (phenobarbital
etc), benzodiazepines (diazepam etc), buspirone, calcium channel blockers
(diltiazem, nifedipine etc), carbamazepine, codeine, ciclosporin,
dextromethorphan, digoxin, ergot alkaloids, ethinylestradiol, fentanyl,
haloperidol, HMG-CoA
reductase inhibitors (atorvastatin etc), ivabradine, levonorgestrel,
lidocaine, macrolide antibiotics (erythromycin etc), mifepristone, estradiol,
ondansetron, omeprazole, paracetamol, PDE5 inhibitors (sildenafil etc),
quinidine,
quinine, selective serotonin reuptake inhibitors (fluoxetine etc), taxanes
(paclitaxel etc), testosterone, theophylline, tricyclic antidepressants
(amitriptyline etc), valproate, venlafaxine, warfarin, various anticancer agents
3A4 inhibitors
amiodarone, azole antifungals (ketoconazole etc), bergamottin (constituent of
grapefruit juice), cimetidine, ciprofloxacin, ciclosporin, diltiazem,
imatinib, macrolide antibiotics (erythromycin etc), metronidazole,
non-nucleoside
reverse transcriptase inhibitors (efavirenz, nevirapine etc)2, protease
inhibitors (saquinavir etc), selective serotonin reuptake inhibitors (fluoxetine
etc),
verapamil
These shall help you to find out, if these 2 enzymes are in your case working
or not. In the literature is often mentioned that the quinolones inhibit 1A2
and 3A4. The question is for how long. In normal persons it should be only for
a short time. In my case it seems that there is an inhibition over many years
now.
So for example if you react against caffeine, anise, dill, fennel, smell of
chemicals, perfumes , it is likely that 1A2 does not work and you should avoid
other substances , which are broken down by this enzyme.
------------------------------------------------------------------------------
---------------
Wikipedia - Cyp450
en.wikipedia.org/wiki/Cyp450
Cytochrome P450 oxidase (commonly abbreviated CYP) is a generic term for a
large number of related, but distinct, oxidative enzymes (EC 1.14) important in
animal physiology. The cytochrome P450 mixed-function monooxygenase system is
probably the most important element of Phase I metabolism in animals
(metabolism in this context being the chemical modification or degradation of
chemicals
including drugs and endogenous compounds)
P450s are membrane-associated proteins, either in the inner membrane of
mitochondria or in the endoplasmic reticulum of cells where they metabolise
thousands of endogenous and exogenous compounds. In the liver, these substrates
include drugs and toxic compounds as well as metabolic products such as
bilirubin
(a breakdown product of hemoglobin). Cytochromes P450 are present in many other
tissues of the body including the mucosa of the gastrointestinal tract, and
play important roles in hormone synthesis and breakdown (including estrogen and
testosterone synthesis and metabolism), cholesterol synthesis, and vitamin D
metabolism. In most animals, including humans, hepatic cytochromes P450 are
the most widely studied of the P450 enzymes.
------------------------------------------------------------------------------
-----------
1A2
substrates
cineole - eucalyptol;
coumarin - blossoms and leaves,lavender oil, gras and clover,
skatol - rotting of proteins,faeces
aflotoxin (toxin from mold)
xantine-caffeine (coffee, tea, chocolate )
pesticides
alcohol
genistein -flavonoid, soybeans
nicotin
naphthalen-moth control, tanning agents, colors
piperazine-can be in gums/plastic
phenylphenol-it is put on the skin of bananas and citrus fruits
organic solvents
marijuana
linoleic acid - fatty acid
melatonin
arachidonic acid
estrogen
phosphatidylcholine-phospholipid
progesteron
uroporphyrinogen-Porphyria
diclofenac
Paracetamol;
Acetanilide (used as test/marker substrate);
NSAID;
cinnarizine-antihistamines/ piperazine;
Diphenhydramine- antihistamines;
benzodiazepine - Anxiolytic, sedative,
Fluoxetine- Selective serotonin reuptake inhibitor, SSRI(antidepressant)
;Lidocain-Local anesthetic;
tetracyclic antidepressants;
Propofol-General anesthetic;
Inhibitor:
Hop (Chalcone);
Hydroxystilbene deriv.- Herbal const -used in some colors,fungicide,rhubarb;
Naringenin, potent inhibitor( is what makes grapefruit taste bitter);
Bergamottin- Grapefruit juice subst -used in Earl Grey Tea and in hair oil.,
Adrenaline;
Apiaceous vegetables like: anise, dill, fennel, caraway, carrot, parsley,
celeriac;
Apigenin (potent inhibitor)- Grapefruit juice subst., celery, parsley,
blossoms of Chrysanthenum;
Coumarin- smell of fresh cut grass or if it fades (smell of hey); is in
Apiaceae, too
Chrysin (potent inhibitor), blossoms of poplar, "Coniferen, Fagales, Rosales,
Bignoniaceae"(does anyone know what kind of plants they are?.
Epicatechin- Catechin, Green tea comp -recognizable at the brown parts on
apples potatoes, when they got pressure or were cut
Galangin; - galanga - a kind of ginger
Genistein - soybeans;
Indole 3-acetaldehyde - neurotransmitter;
Interleukin (IL)-2 (at high conc.);
Lidocain- local anesthetic;
methanol;
phenol-olive oil component, pine wood and needle, tar...;
parathion - pesticide;
Isothiocyanate, Cruciferous vegetables const.;
Contain mustard seed oil: all cabbage, rape, turnip, radish, horseradish,
caper, cress, mustard, wall flower
propofol - General anesthetic;
Protein deficiency;
Quercetin- Grapefruit juice, strawberry etc. subst., in the bark of trees
(oak) +shells and skin of many fruits and vegetables + their leaves, onions,
camomile, hop, whitethorn, appletree, roses, cress, St John's Wort
Rhaponticin- Herbal const., trans-Hydroxystilbene deriv. - rhubarb
Serotonin;( is very much in bananas and pineapple)
Tangeretin- Orange;
Phytoalexin (in red wine, grape, peanuts), trans-Hydroxystilbene;
Phytoalexine -substances, which plants produce to defend themselves against
fungus
-which may be important in our case: capsidicin (makes pepper hot);wyeron
-horse-beans
Tryptamine-neurotransmitter;
--------------------
en.wikipedia.org/wiki/CYP1A2
1A2 substrates
amitriptyline, caffeine, clomipramine, clozapine, cyclobenzaprine, estradiol,
fluvoxamine, haloperidol, imipramine, mexiletine, naproxen, olanzapine,
ondansetron, paracetamol, propranolol, riluzole, ropivacaine, tacrine,
theophylline, tizanidine, verapamil, warfarin, zileuton, zolmitriptan
1A2 inhibitors
amiodarone, cimetidine, fluoroquinolones (ciprofloxacin, etc), fluvoxamine,
interferon, methoxsalen
-----------------------
medicine.iupui.edu/flockhart/table.htm
1A2 Substrates:
amitriptyline,caffeine,clomipramine,clozapine,cyclobenzaprine,estradiol,
fluvoxamine,haloperidol,imipramine,N-DeMe,mexilletine,naproxen,olanzapine,
ondansetron, phenacetin, acetaminophen,
propranolol,riluzole,ropivacaine,tacrine,theophylline,tizanidine,verapamil,
(R)warfarin,zileuton,zolmitriptan
1A2 inhibtors
amiodarone,cimetidine,ciprofloxacin,fluoroquinolones,fluvoxamine,
furafylline,interferon,methoxsalen,mibefradil,
-----------------------------------------------------------------------------
medicine.iupui.edu/flockhart/table.htm
3A4
substrates
Macrolide antibiotics:clarithromycin,erythromycin, NOT azithromycin,
telithromycin,
Anti-arrhythmics:quinidine
Benzodiazepines:alprazolam,diazepam, midazolam, triazolam
Immune Modulators:cyclosporine,tacrolimus (FK506)
Prokinetic:
cisapride
Antihistamines:
astemizole, chlorpheniramine, terfenidine
Calcium Channel Blockers:
amlodipine,diltiazem,felodipine,lercanidipine,nifedipine,nisoldipine,
nitrendipine,verapamil
HMG CoA Reductase Inhibitors:
atorvastatin,cerivastatin,lovastatin,NOT pravastatin,simvastatin,
Steroid 6beta-OH:
estradiol,hydrocortisone,progesterone,testosterone
Miscellaneous:
alfentanyl,aprepitant,aripiprazole,buspirone,cafergot,caffeine,
cilostazol,cocaine,codeine- N-demethylation,
dapsone,dextromethorphan,docetaxel,domperidone,eplerenone,
fentanyl,finasteride,gleevec,haloperidol,irinotecan,LAAM,lidocaine,
methadone,nateglinide,odanestron,pimozide,propranolol,quetiapine,
quinine,NOT rosuvastatin,salmeterol,sildenafil,sirolimus,tamoxifen,
taxol,terfenadine,trazodone,vincristine,zaleplon,zolpidem,
3A4 inhibitors
amiodarone,aprepitant,NOTazithromycin,chloramphenicol,cimetidine,
clarithromycin,diethyl-dithiocarbamate,
diltiazem,erythromycin,fluconazole,fluvoxamine,gestodene,
grapefruit juice,imatinib,itraconazole,ketoconazole,mifepristone,
nefazodone,norfloxacin,norfluoxetine,mibefradil,star fruit,
verapamil,voriconazole
en.wikipedia.org/wiki/CYP3A4
3A4 substrates
amiodarone, azole antifungals (ketoconazole etc), barbiturates (phenobarbital
etc), benzodiazepines (diazepam etc), buspirone, calcium channel blockers
(diltiazem, nifedipine etc), carbamazepine, codeine, ciclosporin,
dextromethorphan, digoxin, ergot alkaloids, ethinylestradiol, fentanyl,
haloperidol, HMG-CoA
reductase inhibitors (atorvastatin etc), ivabradine, levonorgestrel,
lidocaine, macrolide antibiotics (erythromycin etc), mifepristone, estradiol,
ondansetron, omeprazole, paracetamol, PDE5 inhibitors (sildenafil etc),
quinidine,
quinine, selective serotonin reuptake inhibitors (fluoxetine etc), taxanes
(paclitaxel etc), testosterone, theophylline, tricyclic antidepressants
(amitriptyline etc), valproate, venlafaxine, warfarin, various anticancer agents
3A4 inhibitors
amiodarone, azole antifungals (ketoconazole etc), bergamottin (constituent of
grapefruit juice), cimetidine, ciprofloxacin, ciclosporin, diltiazem,
imatinib, macrolide antibiotics (erythromycin etc), metronidazole,
non-nucleoside
reverse transcriptase inhibitors (efavirenz, nevirapine etc)2, protease
inhibitors (saquinavir etc), selective serotonin reuptake inhibitors (fluoxetine
etc),
verapamil