Post by beebs on Mar 22, 2012 17:40:47 GMT -5
Part I of a rather long article I am reading linking CYP450s,
MCS, EMF, allergies, asthma, hidden porphyria (can develop from
meds ADRs), beta blockers role in Mast Cell Diseases (MCD), intestinial
CYP450s, and the role of certain compounds in foods as mediators. Beta-blockers
role, etc..
The author is a Professor of Physics, Steven Roschiltz, PhD. He spent over 30
years researching environmental illnesses and puts forward some very interesting hypo.
Readers: do not ever give up or accept what your doctors (most of them are ignorant) tell you about your symptoms. Read up, question, critical analysis of what you read, and keep digging for solutions, and how to alleviate if you believe there are no cures!!
Part 1
Introduction
Prof Roschiltz (R) discusses the explosion in environmental illnesses, in particular, Mast Cell Disease (MCD) and hidden porphyria. The latter is difficult to diagnose since tests are corrupt and unreliable.
As a side note, not mentioned in the article, porphyria can be acquired through ADRs to certain meds.
Briefly, mast cells are found in skin, lungs, peritoneum, brain, gastrointestinal mucosa and and nasal mucosa.
These are part of the mechanism to regulate blood-brain-barrier permeability (BBBP). We know that many meds cause damage to blood-brain-barrier (BBB).
Many of you will know that mast cells are involved in allergies or allergy like of reactions.
He discusses that in MCD, those cells are no longer functioning normally. There is an increase of mast cells releasing too much histamine and other toxic substances.
One of the many symptoms is sensitivity to heat and stress, which shows evidence that BBBP is on going.
According to the article, bone marrow creates mast cells, helps with healing wounds, and defends us against micro organisms. Mast cells are present in most tissue surrounding blood vessels and nerves, and skin.
Prevalent in mucosa of mouth, nose, lungs, digestive tract and conunctiva in eyes. Prof R mentions inflammatory diseases and the role of mast cells.
Some of the symptoms from MCD:
Muscle pain, abdominal pain, high or low BP. itching, headache, flushing, bone pain, shock, runny nose, malabsorption, stomach ulcers, dizziness, swellings, papular skin lesions, brown skin patches, reduced blood platelets, enlarged spleen and liver, tachycardia, EMF, MCS and more.
Prof R mentions the similarities between symptoms of MCD and porphyria.
MSG is known to cause or trigger MSD. MSG have natural MSG such as seaweed, tomatoes, peas (see other foods) on ADR-Central to avoid for CNS symptoms.
Cooked meat = high glutamate. MSG is addictive, can cause headaches, anaphylaxis, swelling, linked to heart and vascular disease and diabetes.
Mentioned is vascular ectasia - various tissues infiltrated by mast cells.
If you see red dots on the skin during MSG, food stress, sunlight and heat/cold or can be in stomach, called gastric angtral vascular ectasia. Some call it "watermelon stomach" due to red stripes which can be found during endoscopy.
The symptoms for the above, would include, weakness, tachycardia, palpitations, shortness of breath on slight exertion, poor cognition, paresthesia, irritable, brittle nails ...
Skin sensitivity to touch, clothing etc
Tests for MCD - Skin biopsy to examine mast cells under exposure of some exposures. tryptase blood test and 24 hour urine assay for N-methylhistamine.
He mentions electromagnetic fields (EMF) could cause or trigger or exacerbate mast cell degranulation. Discussed possible EMF role in MCD and/or porphyria.
MCD can be exacerbated by high meat consumption.
Antihistamines and steroids - poorly tolerated by porphyrics.
Some drugs that may help instead: ketotifen and cromolyn sodium
Gunnar Heuser , MD. Discusses link with MCS, MCD, EMF and electromagnetic Hypersensitivity (EHS) with food reactivity.
Prof R made a connection in his book about hidden porphyria resulting in MCD.
20% of the population is genetically predisposed to porphyria.
Heam protein in haemoglobin, 40% of haem helps make cytochrome CYP450 enzymes.
Todate, we know of about 51 CYP450 enzymes in humans. They help with detoxifying include chemicals, vitamins, internal chemicals, metabolic functions, our hormones, and can be found in diferent tissues, including digestive system.
Part II
will discuss CYP450 found in Mast Cells
MCS, EMF, allergies, asthma, hidden porphyria (can develop from
meds ADRs), beta blockers role in Mast Cell Diseases (MCD), intestinial
CYP450s, and the role of certain compounds in foods as mediators. Beta-blockers
role, etc..
The author is a Professor of Physics, Steven Roschiltz, PhD. He spent over 30
years researching environmental illnesses and puts forward some very interesting hypo.
Readers: do not ever give up or accept what your doctors (most of them are ignorant) tell you about your symptoms. Read up, question, critical analysis of what you read, and keep digging for solutions, and how to alleviate if you believe there are no cures!!
Part 1
Introduction
Prof Roschiltz (R) discusses the explosion in environmental illnesses, in particular, Mast Cell Disease (MCD) and hidden porphyria. The latter is difficult to diagnose since tests are corrupt and unreliable.
As a side note, not mentioned in the article, porphyria can be acquired through ADRs to certain meds.
Briefly, mast cells are found in skin, lungs, peritoneum, brain, gastrointestinal mucosa and and nasal mucosa.
These are part of the mechanism to regulate blood-brain-barrier permeability (BBBP). We know that many meds cause damage to blood-brain-barrier (BBB).
Many of you will know that mast cells are involved in allergies or allergy like of reactions.
He discusses that in MCD, those cells are no longer functioning normally. There is an increase of mast cells releasing too much histamine and other toxic substances.
One of the many symptoms is sensitivity to heat and stress, which shows evidence that BBBP is on going.
According to the article, bone marrow creates mast cells, helps with healing wounds, and defends us against micro organisms. Mast cells are present in most tissue surrounding blood vessels and nerves, and skin.
Prevalent in mucosa of mouth, nose, lungs, digestive tract and conunctiva in eyes. Prof R mentions inflammatory diseases and the role of mast cells.
Some of the symptoms from MCD:
Muscle pain, abdominal pain, high or low BP. itching, headache, flushing, bone pain, shock, runny nose, malabsorption, stomach ulcers, dizziness, swellings, papular skin lesions, brown skin patches, reduced blood platelets, enlarged spleen and liver, tachycardia, EMF, MCS and more.
Prof R mentions the similarities between symptoms of MCD and porphyria.
MSG is known to cause or trigger MSD. MSG have natural MSG such as seaweed, tomatoes, peas (see other foods) on ADR-Central to avoid for CNS symptoms.
Cooked meat = high glutamate. MSG is addictive, can cause headaches, anaphylaxis, swelling, linked to heart and vascular disease and diabetes.
Mentioned is vascular ectasia - various tissues infiltrated by mast cells.
If you see red dots on the skin during MSG, food stress, sunlight and heat/cold or can be in stomach, called gastric angtral vascular ectasia. Some call it "watermelon stomach" due to red stripes which can be found during endoscopy.
The symptoms for the above, would include, weakness, tachycardia, palpitations, shortness of breath on slight exertion, poor cognition, paresthesia, irritable, brittle nails ...
Skin sensitivity to touch, clothing etc
Tests for MCD - Skin biopsy to examine mast cells under exposure of some exposures. tryptase blood test and 24 hour urine assay for N-methylhistamine.
He mentions electromagnetic fields (EMF) could cause or trigger or exacerbate mast cell degranulation. Discussed possible EMF role in MCD and/or porphyria.
MCD can be exacerbated by high meat consumption.
Antihistamines and steroids - poorly tolerated by porphyrics.
Some drugs that may help instead: ketotifen and cromolyn sodium
Gunnar Heuser , MD. Discusses link with MCS, MCD, EMF and electromagnetic Hypersensitivity (EHS) with food reactivity.
Prof R made a connection in his book about hidden porphyria resulting in MCD.
20% of the population is genetically predisposed to porphyria.
Heam protein in haemoglobin, 40% of haem helps make cytochrome CYP450 enzymes.
Todate, we know of about 51 CYP450 enzymes in humans. They help with detoxifying include chemicals, vitamins, internal chemicals, metabolic functions, our hormones, and can be found in diferent tissues, including digestive system.
Part II
will discuss CYP450 found in Mast Cells