Post by beebs on Jan 15, 2012 8:47:38 GMT -5
Double-edge sword. Excess or deficency causes
dsyfunction in eletrophysiological of neuronal activities.
But then again, so do other minerals. Zinc excess or deficiencies
also can cause dysfunction. Difficult one here, no tests available.
Urine, serum and tissue all differ. Perhaps experimenting with foods
high in manganese and other minerals
such as www.healthaliciousness.com/articles/foods-high-in-manganese.php and www.whfoods.com/genpage.php?tname=nutrient&dbid=77
Heard mixed results from those supplementing on Manganese.
Not come across any papers which discusses the mechanism
behind accumulation of certain compiounds in one part of the body
Brain Res Brain Res Rev. 2003 Jan;41(1):79-87.
Manganese action in brain function.
Takeda A.
Source
Department of Medical Biochemistry, School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, 422-8526, Shizuoka, Japan. takedaa@u-shzuoka-ken.ac.jp
Abstract
Manganese, an essential trace metal, is supplied to the brain via both the blood-brain and the blood-cerebrospinal fluid barriers. There are some mechanisms in this process and transferrin may be involved in manganese transport into the brain. A large portion of manganese is bound to manganese metalloproteins, especially glutamine synthetase in astrocytes. A portion of manganese probably exists in the synaptic vesicles in glutamatergic neurons and the manganese is dynamically coupled to the electrophysiological activity of the neurons. Manganese released into the synaptic cleft may influence synaptic neurotransmission. Dietary manganese deficiency, which may enhance susceptibility to epileptic functions, appears to affect manganese homeostasis in the brain, probably followed by alteration of neural activity. On the other hand, manganese also acts as a toxicant to the brain because this metal has prooxidant activity. Abnormal concentrations of manganese in the brain, especially in the basal ganglia, are associated with neurological disorders similar to Parkinson's disease. Understanding the movement and action of manganese in synapses may be important to clarify the function and toxicity of manganese in the brain.www.ncbi.nlm.nih.gov/pubmed/12505649?dopt=Abstract&holding=f1000,f1000m,isrctn