Post by beebs on Sept 11, 2011 17:35:00 GMT -5
Palm Oil which is rich in tocotrienol and tocopherols (Vit E), is beneficial for oxidative stress. Rice bran contains tocotrienol and tocopherols too.
The Effects of Palm Oil Tocotrienol-Rich Fraction Supplementation on Biochemical Parameters, Oxidative Stress and the Vascular Wall of Streptozotocin-Induced Diabetic Rats
Siti Balkis Budin,I Faizah Othman,II Santhana Raj Louis,III Mokhtar Abu Bakar,IV Srijit Das,II and Jamaludin MohamedI
I Department of Biomedical Science, Faculty of Allied Health Sciences, Universiti Kebangsaan – Malaysia
II Department of Anatomy, Faculty of Medicine, Universiti Kebangsaan Malaysia - Malaysia
III Division of Electron Microscope, Institute for Medical Research - Malaysia
IV Department of Pathology, Faculty of Medicine, Universiti Kebangsaan Malaysia - Malaysia. Tel.: 603 40405645, Email: amira@medic.ukm.my
Received September 29, 2008; Accepted November 24, 2008.
OBJECTIVE
This study examined the effects of palm oil tocotrienol-rich fractions on streptozotocin-induced diabetic rats.
METHODS
Animals were divided into three groups: (i) normal non-diabetic (NDM), (ii) diabetic treated (tocotrienol-rich fractions - TRF) and (iii) diabetic untreated (non-TRF). The treatment group received oral administration of tocotrienol-rich fractions (200 mg/kg body weight) daily for eight weeks. The normal non-diabetic and the diabetic untreated groups were fed standard rat feed. Blood glucose and lipid profiles, oxidative stress markers and morphological changes of the thoracic aorta were evaluated.
RESULTS
Tocotrienol-rich fractions treatment reduced serum glucose and glycated hemoglobin concentrations. The tocotrienol-rich fractions group also showed significantly lower levels of plasma total cholesterol, low-density lipoprotein cholesterol, and triglyceride, as compared to the untreated group. The tocotrienol-rich fractions group had higher levels of high-density lipoprotein cholesterol, as compared to the untreated group. Superoxide dismutase activity and levels of vitamin C in plasma were increased in tocotrienol-rich fractions-treated rats. The levels of plasma and aorta malondealdehyde + 4-hydroxynonenal (MDA + 4-HNE) and oxidative DNA damage were significant following tocotrienol-rich fractions treatment. Electron microscopic examination showed that the normal morphology of the thoracic aorta was disrupted in STZ-diabetic rats. Tocotrienol-rich fractions supplementation resulted in a protective effect on the vessel wall.
CONCLUSION
These results show that tocotrienol-rich fractions lowers the blood glucose level and improves dyslipidemia. Levels of oxidative stress markers were also reduced by administration of tocotrienol-rich fractions. Vessel wall integrity was maintained due to the positive effects mediated by tocotrienol-rich fractions.
Keywords: Tocotrienol-rich fraction, Antioxidant, Diabetes mellitus, Oxidative stress, Dyslipidemia, Vascular morphology
Cont/... www.ncbi.nlm.nih.gov/pmc/articles/PMC2666447/
The Effects of Palm Oil Tocotrienol-Rich Fraction Supplementation on Biochemical Parameters, Oxidative Stress and the Vascular Wall of Streptozotocin-Induced Diabetic Rats
Siti Balkis Budin,I Faizah Othman,II Santhana Raj Louis,III Mokhtar Abu Bakar,IV Srijit Das,II and Jamaludin MohamedI
I Department of Biomedical Science, Faculty of Allied Health Sciences, Universiti Kebangsaan – Malaysia
II Department of Anatomy, Faculty of Medicine, Universiti Kebangsaan Malaysia - Malaysia
III Division of Electron Microscope, Institute for Medical Research - Malaysia
IV Department of Pathology, Faculty of Medicine, Universiti Kebangsaan Malaysia - Malaysia. Tel.: 603 40405645, Email: amira@medic.ukm.my
Received September 29, 2008; Accepted November 24, 2008.
OBJECTIVE
This study examined the effects of palm oil tocotrienol-rich fractions on streptozotocin-induced diabetic rats.
METHODS
Animals were divided into three groups: (i) normal non-diabetic (NDM), (ii) diabetic treated (tocotrienol-rich fractions - TRF) and (iii) diabetic untreated (non-TRF). The treatment group received oral administration of tocotrienol-rich fractions (200 mg/kg body weight) daily for eight weeks. The normal non-diabetic and the diabetic untreated groups were fed standard rat feed. Blood glucose and lipid profiles, oxidative stress markers and morphological changes of the thoracic aorta were evaluated.
RESULTS
Tocotrienol-rich fractions treatment reduced serum glucose and glycated hemoglobin concentrations. The tocotrienol-rich fractions group also showed significantly lower levels of plasma total cholesterol, low-density lipoprotein cholesterol, and triglyceride, as compared to the untreated group. The tocotrienol-rich fractions group had higher levels of high-density lipoprotein cholesterol, as compared to the untreated group. Superoxide dismutase activity and levels of vitamin C in plasma were increased in tocotrienol-rich fractions-treated rats. The levels of plasma and aorta malondealdehyde + 4-hydroxynonenal (MDA + 4-HNE) and oxidative DNA damage were significant following tocotrienol-rich fractions treatment. Electron microscopic examination showed that the normal morphology of the thoracic aorta was disrupted in STZ-diabetic rats. Tocotrienol-rich fractions supplementation resulted in a protective effect on the vessel wall.
CONCLUSION
These results show that tocotrienol-rich fractions lowers the blood glucose level and improves dyslipidemia. Levels of oxidative stress markers were also reduced by administration of tocotrienol-rich fractions. Vessel wall integrity was maintained due to the positive effects mediated by tocotrienol-rich fractions.
Keywords: Tocotrienol-rich fraction, Antioxidant, Diabetes mellitus, Oxidative stress, Dyslipidemia, Vascular morphology
Cont/... www.ncbi.nlm.nih.gov/pmc/articles/PMC2666447/