|
Post by msnycgal on Apr 21, 2011 10:18:06 GMT -5
Ok, so I decided to post this under recovered although I'm not 100% recovered but hope to be someday. I got floxed 2 years ago after one 500 mgs pill of levaquin. The reaction was immediate and extremely severe. I almost died that night. No kidding. The next 4 months proved to be the most hellish experience of my life. Anything and everything you can think of, read, heard of or experienced yourself, you name it , I had it. From severe insomnia - no sleep for 3 months -- to anxiety, panic attacks, to system wide tendon/ligament damage, muscle wasting, intractable constipation, food sensitivities, blurry vision, light sensitiviy, weight loss, hair loss, skin rashes and breakouts, numbness in feet and hands, palpitations, acid reflux, high blood pressure, diabetes insipidus, sore on the inside of my cheeks, high liver enzymes, high inflammation markers, fibromas in the feet, burning sensation all over my body, dry eyes, nose, ears and nose, cracking and popping joints all over my body, weakness beyond description, agitation, crying jags, and more and much more.... I was homebound for 3 months, could not take care of my family, could no walk for more than a few feet, could not stand for more than a few minutes, could not cook, read, watch TV or do anything that would distract me from the overwhelming sense that I was dying. And then.. after a steady decline for months, miraculously, I started to feel better. At almost exactly the 4 month mark. Slowly but surely, things started to improve. One by one. I went back to work 6 months after I got floxed. Where am I now, 2 years later. I have my life back and lead a normal life. I can walk long distances without any real problems. Most of the symptoms are gone most of the time. Occasionally I have sore/painful tendons, I still experience numbness at night in my left foot and occasionally left hand. I still have that sore on the inside of my cheek which is aggravated by eating sugar. I still can't drink regular coffee without feeling like I'm racing. I still don't sleep through the night, although my sleep has improved tremendously. I have not done any real exercise or strenuous activity so I don't know how well my tendons/joints can tolerate exercise. This is in a nutshell my floxing story. I took no supplements the first 3 months after floxing and started to take quite a few around the 4th month mark. I don't take any supplements these days, although I think I should. I took no medications whatsoever except on 2 occasions, during the first week of floxing, I took two 5 mgs valium. I have not taken any medications whatsoever since then. Neither OT nor prescription. I have not undergone any invasive test and generally stay away from doctors. Wishing all my floxie friends a speedy recovery.
|
|
|
Post by beebs on Apr 21, 2011 19:07:16 GMT -5
Encouraging!!! Your symptoms are so typical of ADRs from FQs and other antibiotics. Like you, I take no meds, no invasive tests, and stay away from doctors. Well done, and wishing you well.
|
|
|
Post by msnycgal on Apr 21, 2011 21:11:59 GMT -5
No, I'm sorry but my symptoms are not typical of Adverse Drug Reaction to "other antibiotics". Just ADR to fluoroquinolones. I know of no other ANTIBIOTICS that causes Central Nervous System toxicity and tendon damage. My reaction is typical of fluoroquinolone poisoning. Period. Not of other antibiotics. I know this forum is a mixed bag of different ADRs but let's not mix things up and confuse the issues.
|
|
|
Post by beebs on Apr 22, 2011 3:00:05 GMT -5
No, I'm sorry but my symptoms are not typical of Adverse Drug Reaction to "other antibiotics". Just ADR to fluoroquinolones. I know of no other antibiotic that causes Central Nervous System toxicity and tendon damage. My reaction is typical of fluoroquinolone poisoning. Period. Not of other antibiotics. I know this forum is a mixed bag of different ADRs but let's not mix things up and confuse the issues. I omitted to say that one of my early symptoms was a burning sensation all over my body which subsided after a few months. But for a while there, I felt like someone had doused me with gasoline all over and lit a fire.... Hum, some other antibiotics DO cause CNS symtpoms & pain in joints, tendonitis. See Keflex: Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); agitation; confusion; dark urine; decreased urination; fever; hallucinations; red, swollen, or blistered skin; seizures; severe or bloody diarrhea; severe stomach pain or cramps; severe tiredness; unusual bruising or bleeding; unusual vaginal pain, odor, or discharge; yellowing of the eyes or skin. More symptoms: www.drugs.com/sfx/keflex-side-effects.html & www.healthboards.com/boards/showthread.php?t=692850Doxycycline is another - some who took this, report tendon rupture, tendonitis, CNS, and other symptoms I have in past seen "tendinitis" or "joints pains, arthralgia, in inserts of containers for Keflex and other antibiotics. Note that it mentions joints pains in the list of symptoms. In anycase, I have met those who have had tendon ruptures and tendinitis after taking Keflex. forum.slowtwitch.com/Slowtwitch_F....tures_P2333675/If you read about other antibiotics, you will find many who suffer from Kefelx toxicity. Corticosteroids, is another which can cause CNS symptoms, just as severe, Lariam/Mefloquine is another. Many others are suffering out there, not making the connection with other antibiotics and their symptoms, they, too need their hellish symptoms validated and acknowledged. Anesthetics, including local anesthetics can and do cause CNS symptoms. An article posted on FAVC showed a clear connection with tendonitis and another antibiotic, I can't remember which one, it could even have been amoxycillin, not sure though. Definitely not an FQ. Regardless, the British National Formulary, shows clearly, that most antibiotics can and do cause CNS symptoms, including some Cephalosporins and Penicillins, Metronidazole (Flagyl), etc. Many who suffer from ADRs associate their symptoms with Herxeimer reactions, and "healing crisis" and do not make an association with the antibiotics. Even if anecdotal, there is a need to acknowledge and validate others who are battling to have their ADRs symptoms from other antibiotics accepted. Note that most side effects and ADRs are "rare" if we are too believe this. Not quite off the subject, interesting published papers/studies replicated in Spain, Finland, UK, and USA show that 6 out of 10 die as a result of drug toxicity whilst in hospitals. I will post when I find it. In Sweden: www.ncbi.nlm.nih.gov/pubmed/19397805 Read more: health-quest.proboards.com/index.cgi?action=display&board=recovery&thread=16&page=1#ixzz1KEgUtJZg
|
|
|
Post by msnycgal on Apr 22, 2011 8:18:12 GMT -5
I disagree completely.
You said "If you read about other antibiotics, you will find many who suffer from Kefelx toxicity. Corticosteroids, is another which can cause CNS symptoms, just as severe, Lariam/Mefloquine is another".
Corticosteroids, lariam/mefloquine are not antibiotics. Again, let's not confuse the issues. I was objecting to you saying that my experience was typical of " ADRs from fqs and other antibiotics". We are talking about antibiotics here. Not about every medication on the planet. Yes, unfortunately there are millions of people suffering from side effects of medications. No one is disputing that. It's a terrible, terrible thing when the drug you take is more harmful than helpful. Of course. But that's not where our disagreement lies.
Keflex side effects are garden variety side effects of any drug. They are nowhere anything like the fqs and do not last and get worse after you discontinue the drug. Dizziness, agitation and whatever else happens when you take Keflex is a common side effect of many, many drugs and subside when you discontinue. You can have an anaphalactic reaction to any medication. This is not equivalent to the CNS toxicity of the fqs. And Keflex does not damage the connective tissues (tendon, ligament and muscles) and attacks the collagen matrix and cripples you. This is an action unique to fqs antibiotics. The forum you refer to where ONE person complained of tendonitis after many courses of keflex -- including Levaquin by the way -- does not mean that Keflex causes tendon rupture and damage. In any event, the damage that fqs cause to tendons goes so much beyond "tendonitis". Calling the total destruction of the tendons that fqs cause "tendonitis" is a giant joke and is a huge misrepresentation of what really happens to tendons damaged by fqs. If the fqs Black Box warning carried a true representation of what really happens to tendons, no one and I mean no one would risk taking fqs. In comparison, Keflex is used in the pediatric population and has a very safe usage profile. I'm hammering this point because it is a huge disservice to all of us who are advocating for fqs danger awareness to lump the unique crippling effects of fqs -- both physical and mental -- with all the other antibiotics and to say that a lot of antibiotics have the same effects, because they do not.
|
|
|
Post by sejohn1969 on Apr 22, 2011 14:59:24 GMT -5
I totally agree, msnycgal - FQs are in a class by themselves (no pun intended). As a product of Generation X, I have taken every antibiotic there is in my short lifetime (I am 42) and have experienced a multitude of side effects from them, but none have ever come close to the crippling, life-changing effects of Levaquin. In the 90s and beyond, my GPs would hand out antibiotics like candy. I have always been told that antibiotics are harmless and they were given to me whenever I went to the doc complaining of sinus symptoms (which was an average of 6 times a year for the past 20 years). I only started getting FQs in the last 8 years. I have taken at least 5 ten-day courses of Levaquin and a few courses of Cipro without any issues until the final 10-day course of Levaquin I took 14 months ago. That was the straw that broke the camel's back.
|
|
|
Post by beebs on Apr 22, 2011 18:11:59 GMT -5
You said "If you read about other antibiotics, you will find many who suffer from Kefelx toxicity. Corticosteroids, is another which can cause CNS symptoms, just as severe, Lariam/Mefloquine is another". Hum, Keflex is an antibiotic and does cause severe CNS symptoms, and sometimes, lasts for quite a while, specially, if taking psychotropics.I included Corticosteroids because they too cause nasty CNS symptoms and horrific musculoskeletal injury. I know of two people in wheelchair, from taking corticosteroids, for over ten years. See this paper: www.ncbi.nlm.nih.gov/pubmed/18690950.Lariam/mefloquine a cousin of the fluoroquinolones is also known to cause "horrific" CNS issues. A simple read at Lariam yahoo boards would suffice, as would numerous published papers.
The CNS and neuro symptoms from Lariam can last a long time, and even longer if taking psychotropics. Its difficult to ascertain, because so many take drugs. The hallucinations, psychosis etc in some cases are known to have lasted a few years even when not taking psychotropics. Symptoms eventually fade in time. Its also subjective and depends on the self coping mechanism, self concept, support network etc. But for the most part, symptoms last for six to a year.Again, let's not confuse the issues. I was objecting to you saying that my experience was typical of " ADRs from fqs and other antibiotics". We are talking about antibiotics here. Not about every medication on the planet. Yes, unfortunately there are millions of people suffering from side effects of medications. No one is disputing that. It's a terrible, terrible thing when the drug you take is more harmful than helpful. Of course. But that's not where our disagreement lies. Well, we will have to disagree on those points. I have my own experience with lariam, possibly FQs and other antibiotics, and that of others. In time, there will be other members who will also tell their stories about their CNS horrors with other antibiotics.Keflex side effects are garden variety side effects of any drug. They are nowhere anything like the fqs and do not last and get worse after you discontinue the drug. Dizziness, agitation and whatever else happens when you take Keflex is a common side effect of many, many drugs and subside when you discontinue. You can have an anaphalactic reaction to any medication. This is not equivalent to the CNS toxicity of the fqs. And Keflex does not damage the connective tissues (tendon, ligament and muscles) and attacks the collagen matrix and cripples you. This is an action unique to fqs antibiotics. Keflex does cause damage to tendons and joints, but the extent or mechanism, we don't know. It may not be acknowledged, it does not mean its not happening. We simply don't know at this time.
Keflex can cause severe CNS, hallucinations, psychosis, severe insomnia etc much the same as FQs. Stated in the BNF and I met others who suffered from CNS Keflex toxicity.
I know personally of two who took doxy and suffered ruptured tendons and similar injuries to FQs. Here are some links about doxycycline and tendon ruptures:www.ehealthme.com/ds/doxycycline/tendon+rupture ttp://tinyurl.com/3p55sljwww.ncbi.nlm.nih.gov/pubmed/17260615The forum you refer to where ONE person complained of tendonitis after many courses of keflex -- including Levaquin by the way -- does not mean that Keflex causes tendon rupture and damage. In any event, the damage that fqs cause to tendons goes so much beyond "tendonitis". Calling the total destruction of the tendons that fqs cause "tendonitis" is a giant joke and is a huge misrepresentation of what really happens to tendons damaged by fqs. If the fqs Black Box warning carried a true representation of what really happens to tendons, no one and I mean no one would risk taking fqs. In comparison, Keflex is used in the pediatric population and has a very safe usage profile. I'm hammering this point because it is a huge disservice to all of us who are advocating for fqs danger awareness to lump the unique crippling effects of fqs -- both physical and mental -- with all the other antibiotics and to say that a lot of antibiotics have the same effects, because they do not. There are other forums where others complain of tendonitis after taking Keflex. In particular, other health forums such as Lyme, CFS, etc.
FQs research papers do not truly depict some who suffer tendonitis, nor does published papers about other antibiotic toxicities. It takes years for toxicities from meds to be validated. All medications carry warnings of possible side effects, as rare... And not offering support or validating others who are also suffering, is cruel. They too suffer.
There are many others out there who also suffer from tendon ruptures and similar injuries to that of FQs from Keflex. A simple search will show several people complaining of this.
Its irrelevant if there is research about Keflex tendonitis at this point in time. Eventually, in time, it will be found that Keflex can and does cause severe CNS and tendon damage, regardless of the mechanism. Simvastatin, a statin is also known to cause tendon rupture and other meds. It does not mean, that those people don't suffer as much, even if the mechamism differs.
www.ncbi.nlm.nih.gov/pubmed/18690950 As far as I understand this board is advocating toxicicities from other antibiotics, and this will serve the purpose of exposing and validating others who are also suffering out there. FQs are not the only antibiotics causing "crippling" symptoms, the mention of side effects for those antibiotics, and pharmacokinetics of drugs and patients variability in metabolizing, remains just that. Meaning, that all antibiotics can and do cause crippling symptoms, and doxy for one can cause tendon/ruptures.
I would like to keep an open mind about others who took antibiotics other than FQs, and their ADRs. I met quite a few who were severely damaged by Keflex, Amoxy, Flagyl (metro) Doxy and penicillin. They had no forums to go to... Now they do!! End of discussion for me. Beebs
|
|
|
Post by msnycgal on Apr 22, 2011 20:43:13 GMT -5
Beebs:
I think it's great that this forum will give all people who suffer from drug ADRs a place to vent and get support. God only knows how many people are out there suffering unspeakable side effects from drugs and most of the time without even knowing it.
There is undoubtedly a number of medications out there that cause severe CNS injuries. Lariam is one of them. Anesthesia, psychotropic drugs, and others. Yes, statin drugs can cause tendon injuries. But again we're talking about antibiotics here. Fqs injuries are in a class of their own as far as antibiotics go. There is no question about it. And no reasonable person would disagree with this statement. And again I would say that my experience is typical of ADRs to fqs and fqs only.
|
|
Deleted
Deleted Member
Posts: 0
|
Post by Deleted on Apr 23, 2011 6:05:20 GMT -5
Msnycgal, you seem to be convinced that the FQs have a unique way of causing damage. What makes it so unique and do you know the mechanisms? I don't want to provocate, but I have worked on another more "general" mechanism involving the production of free radical. It would be good, if we make a thread, where we can post the special/ unique mechaisms done by the quins, what do you think? Namid
|
|
|
Post by msnycgal on Apr 23, 2011 8:04:21 GMT -5
Namid:
If I only knew HOW and WHY fqs do what they do ! and even then I don't think it would make much difference !!! All I know is WHAT they do because I've experienced it myself. Better scientific minds have been trying to elucidate that question but without much success I'm afraid so I don't think I could contribute to a new thread on the subject.
I have always been impressed with your biology knowledge so may be you can start the thread and see if anyone out there can contribute.
|
|
Deleted
Deleted Member
Posts: 0
|
Post by Deleted on Apr 24, 2011 3:54:01 GMT -5
Last fall I spent several months in another forum, where many people with many different illnesses and symptoms were meeting. You know, I have worked a lot on the NO ONOO cycle by Pall and I am convinced that it plays an important role in us caused by the quins, but in addition our huge amount of damage must be seen in others, too. There have been a few persons, but I am always touched when I return to the quinolone scene and to see how badly many of us are hit. Therefore I assume there are 2 different types of mechanisms - the free radicals and something more unique done by the fqs.
|
|
|
Post by piglet on Apr 26, 2011 10:33:29 GMT -5
Keflex side effects are garden variety side effects of any drug. They are nowhere anything like the fqs and do not last and get worse after you discontinue the drug. Dizziness, agitation and whatever else happens when you take Keflex is a common side effect of many, many drugs and subside when you discontinue. You can have an anaphalactic reaction to any medication. This is not equivalent to the CNS toxicity of the fqs. And Keflex does not damage the connective tissues (tendon, ligament and muscles) and attacks the collagen matrix and cripples you. This is an action unique to fqs antibiotics. The forum you refer to where ONE person complained of tendonitis after many courses of keflex -- including Levaquin by the way -- does not mean that Keflex causes tendon rupture and damage. In any event, the damage that fqs cause to tendons goes so much beyond "tendonitis". Calling the total destruction of the tendons that fqs cause "tendonitis" is a giant joke and is a huge misrepresentation of what really happens to tendons damaged by fqs. If the fqs Black Box warning carried a true representation of what really happens to tendons, no one and I mean no one would risk taking fqs. In comparison, Keflex is used in the pediatric population and has a very safe usage profile. I'm hammering this point because it is a huge disservice to all of us who are advocating for fqs danger awareness to lump the unique crippling effects of fqs -- both physical and mental -- with all the other antibiotics and to say that a lot of antibiotics have the same effects, because they do not. I took Macrobid an non quinolone antibiotic and this drug destroyed my arms with debilitating weakness, tendinitis, and pain. It also caused PN. These symptoms lasted 18 months AFTER taking the drug AND I developed SEVERE photosensitivity on arms and neck 9 months AFTER discontinuing. No I was not taking any other drugs that could be blamed. I know for a fact that all these drugs are toxic and and cause both lasting and delayed responses. Quinolones are not the only ones that do. Furthermore, other family members who underwent anesthesia, chemotherapy, and the ingestion of other toxic pharmaceuticals developed both lasting AND delayed reactions to these drugs. All pharmaceuticals are toxic waste. I will NEVER EVER go to a western hospital, doctor or clinic ever again. Western medicine does more harm than good, from the torturous and backward practice of animal experimentation to the engineering of super bacteria and viruses. Top to bottom a totally corrupt system that kills people and makes money off of keeping people sick.
|
|
|
Post by beebs on Apr 27, 2011 11:45:56 GMT -5
All pharmaceuticals are toxic waste. I will NEVER EVER go to a western hospital, doctor or clinic ever again. Western medicine does more harm than good, from the torturous and backward practice of animal experimentation to the engineering of super bacteria and viruses. Top to bottom a totally corrupt system that kills people and makes money off of keeping people sick. Agree. Some emergencies, can be life saving, for the most part, not. I live by what I preach and not taking meds or had invasive investigative procedures for several years now. The last one, was using galdolinium contrast dye. It caused my kidneys to fail, constant angina, either triggered hypthyroidism, or worsened it, as well as worsened all my other symptoms, giving new ones. That was the last straw...
|
|
|
Post by floxiemoxie1 on Apr 30, 2011 14:53:35 GMT -5
Hi msnycgal,
I am so happy for you that you've seen such improvements since your floxing, that's very encouraging. I too am just over two years out from my last floxing but I haven't been quite as fortunate. I'm still hopeful though, and it helps to read about other's improvements. Thank you for sharing your story with all of us.
|
|
|
Post by James Harden on Apr 30, 2011 15:09:18 GMT -5
What do you guys think of "The flox report" Do you think most of what it says is accurate? Just curious. Thanks.
|
|
|
Post by beebs on Apr 30, 2011 17:10:49 GMT -5
What do you guys think of "The flox report" Do you think most of what it says is accurate? Just curious. Thanks. Which version of The Flox Report? The first original or the second revised version? ;D
|
|
|
Post by djuhnigp on Oct 22, 2020 5:02:37 GMT -5
buying viagra pharmexpresstores.com/ womens viagra order viagra buy viagra pills <a href=https://pharmexpresstores.com/#>womens viagra</a> viagra without a doctor prescription
|
|
|
Post by kebbkmby on Nov 3, 2020 16:09:40 GMT -5
viagra 100 mg best price silviagen.com/ - viagra order online best canadian pharmacy viagra 50mg price men viagra order viagra professional
|
|