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Post by beebs on Jul 19, 2011 9:38:36 GMT -5
I can't remember if posted this or not, but well, good info to show your doctors. Aspirin and other drugs can cause tinnitus. Proceedings of the National Academy of Sciences of the United States of America "Mice with behavioral evidence of tinnitus exhibit dorsal cochlear nucleus hyperactivity because of decreased GABAergic inhibition."Abstract: Tinnitus has been associated with increased spontaneous and evoked activity, increased neural synchrony, and reorganization of tonotopic maps of auditory nuclei. However, the neurotransmitter systems mediating these changes are poorly understood. Here, we developed an in vitro assay that allows us to evaluate the roles of excitation and inhibition in determining the neural correlates of tinnitus. To measure the magnitude and spatial spread of evoked circuit activity, we used flavoprotein autofluorescence (FA) imaging, a metabolic indicator of neuronal activity. We measured FA responses after electrical stimulation of glutamatergic axons in slices containing the dorsal cochlear nucleus, an auditory brainstem nucleus hypothesized to be crucial in the triggering and modulation of tinnitus. FA imaging in dorsal cochlear nucleus brain slices from mice with behavioral evidence of tinnitus (tinnitus mice) revealed enhanced evoked FA response at the site of stimulation and enhanced spatial propagation of FA response to surrounding sites. Blockers of GABAergic inhibition enhanced FA response to a greater extent in control mice than in tinnitus mice. Blockers of excitation decreased FA response to a similar extent in tinnitus and control mice. These findings indicate that auditory circuits in mice with behavioral evidence of tinnitus respond to stimuli in a more robust and spatially distributed manner because of a decrease in GABAergic inhibition. www.ncbi.nlm.nih.gov/pubmed/21502491
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Post by Deleted on Jul 19, 2011 9:42:18 GMT -5
great article Thank you for posting it Namid
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Post by Deleted on Jul 19, 2011 9:54:09 GMT -5
I just looked up if there is in addition a connection toward the TRPV1 receptor Authors: Carol A. Bauer; Thomas J. Brozoski; Kristin S. Myers The International Tinnitus Journal Acoustic Injury and TRPV1 Expression in the Cochlear Spiral Ganglion Vol. 13 nº 1 - Jan/Feb/Mar de 2007 Pages: 21 - 28 www.tinnitusjournal.com/detalhe_artigo.asp?id=112Abstract: Acoustic trauma not only produces temporary and permanent hearing loss but is a common cause of chronic tinnitus. Recent work indicated a possible role for the transient receptor potential channel vanilloid subfamily type 1 (TRPV1) in modulating the effects of cochlear injury. In our research, we investigated the effects of acoustic damage on TRPV1 expression in spiral ganglion neurons of adult rats. After exposing them unilaterally to noise, we extracted cochleas and processed the spiral ganglion for TRPV1 expression at four posttrauma intervals (2 hours, 24 hours, 12 days, and 16.9 months). We measured TRPV1 immunodensity in the apical, middle, and basal turns of the cochlea. We found a significant interaction (p = .039) between posttrauma interval and regional cochlear receptor expression: For survival intervals between 24 hours and 2 weeks, TRPV1 density increased in all cochlear regions; at the longest survival interval (16.9 months), TRPV1 density was dramatically reduced in the basal region. We also psychophysically tested the long-survival subjects, which showed evidence of 20-kHz tonal tinnitus. These results suggest that TRPV1 may participate after cochlear injury in a signal cascade that is responsible for the neuroplastic events leading to tinnitus and hyperacusis.
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Post by beebs on Jul 19, 2011 14:49:46 GMT -5
WoW, Namid, thanks for posting this.
Interesting. Wonder if its all connected with difficulties in metabolizing compounds from foods, environment in the sense, that many of us are diagnosed suffering hyperacusis and tinnitus, AND MCS? What do you think?
Could it be, that the damage that is suggested leading to some type of neuroplasticity, makes the hyperacusis less uncomfortable after a while? As with Vestibular Dysfunction?
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Post by Deleted on Jul 20, 2011 3:27:57 GMT -5
I think the articles we found show a connection. Over the years I noticed that people after they had an exposure would complain about tinnitus. So there is a connection between exposures like chemicals, noise, stress, food...
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